Lanzaderas y Balances
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UNIDAD IV Fase III del Metabolismo Intermediario Lanzaderas (Conexiones intracelulares) y Balances Energéticos Celia Tasende Bioquímica pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Catabolismo de Carbohidratos, Lípidos y Proteínas: Producción de Energía Lípidos Carbohidratos AG+ Glic ACoA Glucosa 2H+ 2e- aa PIR PIR ACoA 2H+ 2H+ 2e- Proteínas CO 2 2e- NH 3 Mitocondria AcetilCoA 2H+ 2e- C de K CO 2 CO 2 NADH FADH 2 NAD FAD ADP H2 O O2 ATP Citosol C é lula pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Ciclo de Krebs y Cadena de Transporte de Electrones H+ H+ H+ + H H+ H+ I ADP Succ H+ OXA O2 Acetil CoA ATP PIR H+ H+ O2 O2 Mitocondria PIR pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! H+ H+ C C MAL Cit 0 /F 1 H+ H+ FUM áCetoGlu H+ Isocit F CoQ II SuccCoA H+ H+ + III H H+ H+ IV H+ Cadena de Transporte de Electrones (Cte-) Entradas de Sustratos y Electrones (e- ) Citosol Membrana Externa áGPDHm áGPDHm CC CoQ I III IV II ACoDH ACo DH = Acil-CoA deshidrogenasa (1er paso â oxidación) Mitocondria Matriz Membrana Interna F0/F1 pdfMachine Membrana Externa A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Lanzaderas Son secuencia de reacciones que sirven para transportar coenzimas o metabolitos de un compartimento a otro de la célula, cuando éstos no atraviesan las membranas celulares por si mismos o no tienen transportador específico. Son estrategias de las células eucariota para conectar diferentes compartimentos. Las conexiones mas importantes en el metabolismo intermediario se dan entre el citosol y la mitocondria. Ejemplos importantes: → → → → → Oxalacetato – Malato (Gluconeogénesis) Acil.CoA – Carnitin-Transferasa (Lipólisis) Acetil.CoA – Citrato (Lipogénesis) Aspartato – Malato (Glucólisis) Alfa-Glicerolfosfato (Glucólisis) pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Carbohidratos Glucosa 2H + 2e - PIR PIR CO 2 2H + 2e - AcetilCoA 2H + 2e - C de K Mitocondria CO 2 CO 2 NADH FADH 2 NAD FAD ADP H 2O O2 ATP Citosol pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! C é lula Oxidación total de la Glucosa en presencia de oxígeno CH2OH H H OH HO H H H + 6 O2 OH OH G’º = - 2842 kJ/mol (- 680 kCal/mol) Libera gran cantidad de energía, se pierde como calor, no se aprovecha para realizar trabajo. 6 CO2 + 6 H2O pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Degradación total de la Glucosa hasta CO2 y H2O Glucosa ATP G6P F6P ATP F1,6BP DHAP Lanzaderas NAD+ GAP NADH 1,3BPG ATP 3PG 2PG PEP ATP PIR PIR NADH CO CO2 AcetilCoA CK NAD+ FAD NADH FADH2 Cte FOx H 2O CO 2 CO 2 ADP + Pi O2 ATP pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Degradación total de la Glucosa hasta CO2 y H2O Glucosa ATP G6P F6P ATP F1,6BP DHAP NAD+ GAP MAL (Red) Lanzadera OXA (Ox) Aspartato-Malato NADH 1,3BPG ATP 3PG 2PG PEP ATP PIR PIR NADH CO CO2 AcetilCoA CK NAD+ FAD NADH FADH2 Cte FOx H 2O CO 2 CO 2 ADP + Pi O2 ATP pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Lanzadera Aspartato – Malato Espacio intermembrana Matriz COO- NAD+ NADH+H + 1 O C COO- HO-C-H CH2 COOmalato COO- Mal-á-cetoglu 2 HO-C-H NAD+ CH2 NADH+H + COO- 3 malato MDHm MDHc CH2 COOoxalacetato O C COO- CH2 COOoxalacetato C-COOH NH3+ NH3+ -OOC CH2 CH2 C- -OOC CH2 CH2 COO- Glutamato Glutamato H ATc 6 NH3+ -OOC CH2 C-COOAspartato H CH2- COOCH2 C O COOá-cetoglutarato 5 CH2- COOCH2 C O COOá-cetoglutarato Glu-Asp pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! 4 ATm NH3+ -OOC CH2 C-COOAspartato H citosol Lanzadera Aspartato – Malato Espacio intermembrana NAD+ malato Matriz Mal-ácetoglu NADH+H + NAD+ Malato NADH+H + MDHm MDHc Oxalacetato Oxalacetato á-cetoglutarato á-cetoglutarato ATc ATm Glutamato Aspartato Glutamato Glu-Asp pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Aspartato Re-oxidación del NADH en la Cadena de Transporte de e-, acoplada a la Fosforilación Oxidativa Citosol H+ H+ H+ H+ H+ H+ H+ H+ H+ CC H+ CoQ I III IV II H+ NADH H+ NAD H+ H+ Mitocondria 2.5 ATP H 2O H+ + 2H + O2 0.5 H+ 2.5 ADP + 2.5Pi Matriz F0/F1 Membrana Interna H+ H+ H+ + H+ H+ H Membrana Externa pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! H+ H+ H+ Lanzadera Aspartato – Malato: Características Transporta poder reductor del Citosol a la Mitocondria y viceversa. Es Bidireccional: todas las reacciones son reversibles. Utiliza 4 enzimas: dos citosólicas (Aspartato Transaminasa ATc y Malato Deshidrogenasa – MDHc) y dos mitocondriales (ATm –MDHm). Responde a las necesidades celulares de NAD+/NADH en citosol o mitocondria. La reoxidación del NADH en la CTe-, acoplada a la FOx, produce 2,5 ATP Es común en la mayoría de los tejidos: Hígado, Músculo, T. Adiposo, Corazón. pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Degradación total de la Glucosa hasta CO2 y H2O Glucosa ATP G6P F6P ATP F1,6BP DHAP NAD+ GAP GliP (Red) Lanzadera DHAP (Ox) Alfa-Glicerol-fosfato NADH 1,3BPG ATP 3PG 2PG PEP ATP PIR PIR NADH CO2 AcetilCoA CK NAD+ FAD NADH FADH2 Cte FOx H 2O CO 2 CO 2 ADP + Pi O2 ATP pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Lanzadera Alfa-Glicerolfosfato Glucólisis NAD+ citosol NADH+H + áGPDHc = á glicerol 3 fosfato deshidrogenasa citosólica áGPDHc CH2OPO3= CH2OH H á Glicerol 3-fosfato C C OH O Dihidroxiacetona fosfato HO CH2OPO3= C H2 Espacio intermembrana á Glicerol P DH m FAD FADH FAD 2 malato Matriz pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Re-oxidación de NADH por la Lanzadera AlfaGlicerolfosfato NAD NADH áGPDHc GlicP Glucólisis Citosol DHAP áGPDHm FAD F ADH2 FADH2 FAD + H + H + H + H + H C C + CoQ I + III FAD ACoDH II H H H + H IV + H2 O Mitocondria H H + + + 2H 0.5 O2 + 1.5ADP + 1.5Pi 1.5ATP Matriz Membrana Interna Membrana Externa F 0 /F H + H 1 H + H + + Citosol pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! H + Lanzadera -Glicerolfosfato: Características Transporta poder reductor solo del Citosol a la Mitocondria. Es Unidireccional. Utiliza 2 enzimas: -Glicerolfosfato Deshidrogenasa Citosólica (GPDHc) y Mitocondrial (GPDHm). GPDHm se encuentra en la cara externa de la membrana interna. La reoxidación del NADH citosólico y entrada a la CTe- a nivel de una FAD-Deshidrogenasa produce 1,5 ATP. Es común en cerebro y músculo en trabajo intenso. pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Balance energético de la Degradación Aeróbica de Glucosa hasta CO2 y H2O: Glucosa 2 ATP 2 NADH GliP Asp-Mal 2 PIR 2 CO2 2 NADH + 5 ATP + 3 ATP 2 Acetil CoA 8 x 2.5 20 ATP 2 NADH 32 ATP 2 NADH 2 CO2 O2 25 ATP 2 NADH 2 CO2 2 E-FADH2 30 ATP 2 GTP 2 x 1.5 3 ATP 2 ATP 35% pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! 32% Balance energético de la Degradación Anaeróbica Glucosa hasta Lactato: Glucosa 2 ATP 2 NADH 2 NAD+ 2 ATP 2 Lac 2 PIR 2 CO2 2 NADH 2 Acetil CoA 2 NADH 2 NADH 2 CO2 2 NADH 2 CO2 2 E-FADH2 O2 2 GTP pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! 2% Balance energético de la Degradación Total de Glucosa hasta CO2 y H2O: 1) Citosol Glc + 2ADP + 2NAD+ + 2Pi 2 PIR + 2 NADH + 2H+ + 2ATP + 2H2O 2) Mitocondria 2 PIR (CPDH) 2 AcetilCoA + 2 CO2 + 2 NADH --------------------------- ( 5 ATP) 2 AcetilCoA (C de K) 4CO2 + 6 NADH + 2GTP + 2 FADH2 ---- (20 ATP) 2 NADH + H+ Reoxidación en Mitocondria a través de Lanzaderas i) Lanz Asp-Mal 2 x 2.5 = 5 ATP ii) Lanz GlicP 2 x 1.5 = 3 ATP PRODUCCIÓN TOTAL DE ATP i) Glc 32 ATP ii) Glc 30 ATP pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Lípidos (TAG) AG + Glic Citosol ACoA ACoA + - + - AcetilCoA 2H + 2e- 2H ++ 2e-- CK Mitocondria CO 2 CO 2 NADH FADH2 NAD FAD ADP H 2 O O2 Célula pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! ATP Re-oxidación de FADH2-NADH provenientes de âOxidación de AG en CTe acoplada a FOx Citosol H+ H+ H+ H+ H+ H+ H+ CC H+ CoQ I H+ H+ NADH NAD H+ H+ III FADH2 ACoDH FAD IV H+ H 2O H+ + 2H + FAD â-Oxidación H+ ATP ADP Mitocondria F0/F1 Membrana Interna H+ Membrana Externa H+ H+ H+ H+ pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! H+ H+ H+ O2 0.5 H+ TAG: Degradación total hasta C02 y H20 CH 2O - CO -(CH 2 ) 16 -CH 3 l CH3-(CH2)16CO-O -CH Triestearato de Glicerol l CH 2 O - CO - (CH 2 ) 16 -CH 3 TAG 3 H 2O Glicerol ATP 3 AG [CH3-(CH2)16COOH] 1 AG (18C) Glic - P NADH DHAP GAP = 2.5 ATP NADH = 2 ATP 2.5 ATP 2 ATP Co A AcilCoA 8 FADH = 8 x 1.5 = 12 ATP 8 NADH = 8 x 2.5 = 20 ATP PIR NADH = AcetilCoA CO CO 2 2.5ATP 10 ATP Producción 18.5 ATP 2 PRODUCCIÓN NETA TOTAL (18C) 9 AcetilCoA CO CO 9x10 = 90 ATP Producción de ATP 2 2 1 AG = 120ATP 3 AG = 360 ATP 1Glicerol (5%) + 3AG (95%) = 18.5 + 360 = 378,5 ATP pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Proteínas aa - PIR PIR 2H - + 2e CO - 2 NH 3 Mitocondria AcetilCoA 2H NADPH/ NADH FADH NAD FAD + 2e - C de K CO CO 2 2 ADP 2 H 2 O O2 ATP Citosol Célula pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Degradación de Aminoácidos hasta C02 + H20 + NH3 Ala, Trip, Ser, Cyst, Gli PIR Acetil CoA CC Asp, AspNH2 OXA Citrato MAL Phe, Tyr Lis,Leu Leu, Lis, , Iso, Trip, Phe, Tyr áCetoGlu FUM SuccCoA Succ Iso, Met, Treo, Val pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Glu, GluNH2 Arg,, His, Pro Degradación total de Alanina hasta C02 + H20 + NH3 CH3-C-COOll PIR O CH3-CH-COOl +NH 3 CO2 NADH Acetil CoA Urea Citrato OXA NADH NADH CO2 MAL áCetoGlu CO2 NADH FUM E-FADH2 Succ SuccCoA GTP 12.5 ATP – 4 ATP = 8.5 ATP pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Lípidos Carbohidratos AG + Glic Glucosa Proteínas Aminoácidos Piruvato CO2 NH3 Acetil-CoA OXC K CC O2 CO2 ADP CTe H2O FOx ATP pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now! Urea Bibliografía Principios de Bioquímica. Lehninger, Nelson & Cox Ediciones Omega 3ra Edición, 2001, 4ra Edición 2005 Biochemistry. Voet & Voet. Wiley & Sons Inc., 1995, Ed Medica Panamericana 2006. Bioquímica. Mathews & van Holde. Ediciones McGraw-Hill Interamericana 2da Edición. pdfMachine A pdf writer that produces quality PDF files with ease! Produce quality PDF files in seconds and preserve the integrity of your original documents. Compatible across nearly all Windows platforms, if you can print from a windows application you can use pdfMachine. Get yours now!