CURRICULUM VITAE Name Consuelo Borras Present post Lecturer

CURRICULUM VITAE
Name Consuelo Borras
Date of birth 27 December 1976
Present post Lecturer in
Nationality Spanish
Physiology (04/2011- )
Work address Department of Physiology
Faculty of Medicine
Telephone 0034-963-864646
Fax 0034-963-864642
e-mail consuelo.borras@uv.es
University of Valencia
Av. Blasco Ibanez 15
E46010 Valencia, Spain
Academic Qualifications
Master of Bioethics
Catholic University of Valencia
09/2006-09/2008
Ph.D. Physiology
Department of Physiology, University of Valencia
06/1999-11/2003
Degree in Pharmacy
Faculty of Pharmacy, University of Valencia
09/1994-06/1999
Previous Academic Appointments
Assistant professor
University of Valencia
04/2008-04/2011
Post-doctoral Researcher
Clinical Hospital of Valencia Foundation
09/2007-04/2008
Lecturer in Physiology
Catholic University of Valencia
09/2005-08/2007
Superior Research Technician University of Valencia
01/2003-08/2005
Ph.D. Student (Grant from
01/2000-12/2003
University of Valencia
the Ministry of Education)
Honours
- “Premio Extraordinario de Licenciatura” University of Valencia, 1999
- Prize for the best Ph.D. thesis “Premio Extraordinario de Doctorado” University of Valencia,
2003
- Young Investigator Award in recognition of extraordinary scientific achievements in the field
of free radical research, awarded by "The Society for Free Radical Research International"
Buenos Aires, 2004.
-“Premio Medalla García Blanco” (2005) in recognition of research career for young
investigators.
- Catherine Pasquier Award (2009) by "The Society for Free Radical Research Europe"
-V Award in Basic Research por La fundación para la Investigación del Hospital Clínico
Universitario de Valencia (INCLIVA)(2010)
Research interests
Gender differences in ageing, oestrogens and phytoestrogens, extreme longevity, stem cells,
Alzheimer’s disease
Funded Research Grants as Principal
Investigator
- Generalitat Valenciana 01/2007-12/2009.
Oxidative stress and diabetes: protective
role of estrogens
- Catholic University of Valencia. Two
small grants to develop a project entitled
“Phytoestrogens
and
up-regulation
of
antioxidant/longevity-related genes”
- Generalitat Valenciana 07/2010-07/2011.
“Study of longevity-related parameters in women treated with estradiol and progesterone after
an induced-menopause”
- INCLIVA 01/2013-12/2013. Intramural call: ““Study of longevity-related parameters in
women treated with estradiol and progesterone after an induced-menopause”
- INCLIVA 01/2015-12/2015. Intramural call: “Effect of genistein and/or bexarotene in the
treatment of Alzheimer’s disease in APP/PS1 mice”
- Conselleria de Sanitat APM-03/15. “Perfiles metabolómicos para la detección temprana de la
fragilidad en ancianos”.
- Generalitat Valenciana AICO/2016/067. “Effect of genistein and/or bexarotene in the
treatment of Alzheimer’s disease in APP/PS1 mice”
Funded Research Grants as Co-applicant
- More than 35 research grants as co-applicant, three of them from the European Community
Citation report
Results found: 69
Sum of the Times Cited: 3100
Average Citations per Item: 44.93
h-index: 29
Average citations per year
Five most cited papers. Average citations: 1261
- Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre
J, Viña J. Oral administration of vitamin C decreases muscle mitocondrial biogenesis and
hampers training-induced adaptations in endurance performance. Am J Clin Nutr. 2008
Jan;87(1):142-9. (Impact factor: 6.7; 302 citations)
- Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viña J, Blasco
MA, Serrano M. Delayed ageing through damage protection by the Arf/p53 pathway. Nature.
2007;448(7151):375-9. (Impact factor: 34.5; 276 citations)
- Borrás C, Sastre J, García-Sala D, Lloret A, Pallardó FV, Viña J. Mitochondria from females
exhibit higher antioxidant gene expression and lower oxidative damage than males. Free Radic
Biol Med. 2003;34(5):546-52. (Impact factor: 6.1; 260 citations)
- Gomez-Cabrera MC, Borrás C, Pallardó FV, Sastre J, Ji LL, Viña J. Decreasing xanthine
oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J
Physiol. 2005 Aug 15;567(Pt 1):113-20. (Impact factor: 4.8; 230 citations)
Title: Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers
training-induced adaptations in endurance performance
- Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borrás C,
Matheu A, Klatt P, Flores JM, Viña J, Serrano M, Blasco MA. Telomerase reverse transcriptase
delays aging in cancer-resistant mice. Cell. 2008 Nov 14;135(4):609-22 (Impact factor: 31.2;
193 citations)
Peer Reviewed Publications
1: Viña J, Tarazona-Santabalbina FJ, Pérez-Ros P, Martínez-Arnau FM, Borras C,
Olaso-Gonzalez G, Salvador-Pascual A, Gomez-Cabrera MC. Biology of frailty:
Modulation of ageing genes and its importance to prevent age-associated loss of
function. Mol Aspects Med. 2016 May 6. pii: S0098-2997(16)30018-8. doi:
10.1016/j.mam.2016.04.005. [Epub ahead of print] Review. PubMed PMID: 27164416.
2: Viña J, Saez GT, Gambini J, Gomez-Cabrera MC, Borrás C. Role of NAD(+)/NADH
redox ratio in cell metabolism: A tribute to Helmut Sies and Theodor Bücher and
Hans A. Krebs. Arch Biochem Biophys. 2016 Apr 1;595:176-80. doi:
10.1016/j.abb.2015.11.027. PubMed PMID: 27095235.
3: Santulli G, Borras C, Bousquet J, Calzà L, Cano A, Illario M, Franceschi C,
Liotta G, Maggio M, Molloy WD, Montuori N, O'Caoimh R, Orfila F, Rauter AP,
Santoro A, Iaccarino G. Models for preclinical studies in aging-related
disorders: One is not for all. Transl Med UniSa. 2016 Jan 31;13:4-12. eCollection
2015 Dec. PubMed PMID: 27042427; PubMed Central PMCID: PMC4811343.
4: Jové M, Naudí A, Gambini J, Borras C, Cabré R, Portero-Otín M, Viña J,
Pamplona R. A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to
Humans. J Gerontol A Biol Sci Med Sci. 2016 Mar 24. pii: glw048. [Epub ahead of
print] PubMed PMID: 27013396.
5: Viña-Almunia J, Borras C, Gambini J, El Alamy M, Peñarrocha M, Viña J.
Influence of different types of pulp treatment during isolation in the obtention
of human dental pulp stem cells. Med Oral Patol Oral Cir Bucal. 2016 May
1;21(3):e374-9. PubMed PMID: 26946201; PubMed Central PMCID: PMC4867212.
6: Bonet-Costa V, Herranz-Pérez V, Blanco-Gandía M, Mas-Bargues C, Inglés M,
Garcia-Tarraga P, Rodriguez-Arias M, Miñarro J, Borras C, Garcia-Verdugo JM, Viña
J. Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment
of Experimental Alzheimer's Disease. J Alzheimers Dis. 2016 Feb 10;51(3):701-11.
doi: 10.3233/JAD-151020. PubMed PMID: 26890773.
7: Gambini J, Gimeno-Mallench L, Inglés M, Olaso G, Abdelaziz KM, Avellana JA,
Belenguer Á, Cruz R, Mas-Bargues C, Borras C, Viña J. [Identification of single
nucleotide polymorphisms in centenarians]. Rev Esp Geriatr Gerontol. 2016
May-Jun;51(3):146-9. doi: 10.1016/j.regg.2015.09.006. Epub 2015 Nov 2. Spanish.
PubMed PMID: 26541311.
8: Gambini J, Inglés M, Olaso G, Lopez-Grueso R, Bonet-Costa V, Gimeno-Mallench
L, Mas-Bargues C, Abdelaziz KM, Gomez-Cabrera MC, Vina J, Borras C. Properties of
Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and
Biological Effects in Animal Models and Humans. Oxid Med Cell Longev.
2015;2015:837042. doi: 10.1155/2015/837042. Epub 2015 Jun 28. Review. PubMed
PMID: 26221416; PubMed Central PMCID: PMC4499410.
9: Viña J, Inglés M, Borrás C. Response to Vidal and colleagues. J Am Geriatr
Soc. 2015 Apr;63(4):838-9. doi: 10.1111/jgs.13362. PubMed PMID: 25900512.
10: Viña J, Gambini J, García-García FJ, Rodriguez-Mañas L, Borrás C. Role of
oestrogens on oxidative stress and inflammation in ageing. Horm Mol Biol Clin
Investig. 2013 Dec;16(2):65-72. doi: 10.1515/hmbci-2013-0039. PubMed PMID:
25436748.
11: El Alami M, Viña-Almunia J, Gambini J, Mas-Bargues C, Siow RC, Peñarrocha M,
Mann GE, Borrás C, Viña J. Activation of p38, p21, and NRF-2 mediates decreased
proliferation of human dental pulp stem cells cultured under 21% O2. Stem Cell
Reports. 2014 Oct 14;3(4):566-73. doi: 10.1016/j.stemcr.2014.08.002. Epub 2014
Sep 18. PubMed PMID: 25358785; PubMed Central PMCID: PMC4223702.
12: Cash TP, Pita G, Domínguez O, Alonso MR, Moreno LT, Borrás C, Rodríguez-Mañas
L, Santiago C, Garatachea N, Lucia A, Avellana JA, Viña J, González-Neira A,
Serrano M. Exome sequencing of three cases of familial exceptional longevity.
Aging Cell. 2014 Dec;13(6):1087-90. doi: 10.1111/acel.12261. Epub 2014 Aug 12.
PubMed PMID: 25116423; PubMed Central PMCID: PMC4326919.
13: Inglés M, Gambini J, Carnicero JA, García-García FJ, Rodríguez-Mañas L,
Olaso-González G, Dromant M, Borrás C, Viña J. Oxidative stress is related to
frailty, not to age or sex, in a geriatric population: lipid and protein
oxidation as biomarkers of frailty. J Am Geriatr Soc. 2014 Jul;62(7):1324-8. doi:
10.1111/jgs.12876. Epub 2014 Jun 24. PubMed PMID: 24962132.
14: Inglés M, Gambini J, Miguel MG, Bonet-Costa V, Abdelaziz KM, El Alami M, Viña
J, Borrás C. PTEN mediates the antioxidant effect of resveratrol at nutritionally
relevant concentrations. Biomed Res Int. 2014;2014:580852. doi:
10.1155/2014/580852. Epub 2014 Apr 10. PubMed PMID: 24812624; PubMed Central
PMCID: PMC4000926.
15: Viña JA, El-Alami M, Gambini J, Borras C, Viña J, Peñarrocha MA. Application
of mesenchymal stem cells in bone regenerative procedures in oral implantology. A
literature review. J Clin Exp Dent. 2014 Feb 1;6(1):e60-5. doi:
10.4317/jced.51186. eCollection 2014 Feb. Review. PubMed PMID: 24596637; PubMed
Central PMCID: PMC3935907.
16: Vina J, Borras C, Sanchis-Gomar F, Martinez-Bello VE, Olaso-Gonzalez G,
Gambini J, Ingles M, Gomez-Cabrera MC. Pharmacological properties of physical
exercise in the elderly. Curr Pharm Des. 2014;20(18):3019-29. Review. PubMed
PMID: 24079769.
17: Viña J, Borras C, Abdelaziz KM, Garcia-Valles R, Gomez-Cabrera MC. The free
radical theory of aging revisited: the cell signaling disruption theory of aging.
Antioxid Redox Signal. 2013 Sep 10;19(8):779-87. doi: 10.1089/ars.2012.5111.
Review. PubMed PMID: 23841595; PubMed Central PMCID: PMC3749699.
18: López-Grueso R, Gambini J, Abdelaziz KM, Monleón D, Díaz A, El Alami M,
Bonet-Costa V, Borrás C, Viña J. Early, but not late onset estrogen replacement
therapy prevents oxidative stress and metabolic alterations caused by
ovariectomy. Antioxid Redox Signal. 2014 Jan 10;20(2):236-46. doi:
10.1089/ars.2012.5112. Epub 2013 Jul 20. PubMed PMID: 23725100; PubMed Central
PMCID: PMC3887441.
19: Viña J, Borras C, Gomez-Cabrera MC. Overweight, obesity, and all-cause
mortality. JAMA. 2013 Apr 24;309(16):1679. doi: 10.1001/jama.2013.3080. PubMed
PMID: 23613062.
20: Gambini J, López-Grueso R, Olaso-González G, Inglés M, Abdelazid K, El Alami
M, Bonet-Costa V, Borrás C, Viña J. [Resveratrol: distribution, properties and
perspectives]. Rev Esp Geriatr Gerontol. 2013 Mar-Apr;48(2):79-88. doi:
10.1016/j.regg.2012.04.007. Epub 2013 Jan 15. Review. Spanish. PubMed PMID:
23332579.
21: Serna E, Gambini J, Borras C, Abdelaziz KM, Belenguer A, Sanchis P, Avellana
JA, Rodriguez-Mañas L, Viña J. Centenarians, but not octogenarians, up-regulate
the expression of microRNAs. Sci Rep. 2012;2:961. doi: 10.1038/srep00961. Epub
2012 Dec 11. Erratum in: Sci Rep. 2013;3:1575. Mohammed, Kheira [corrected to
Abdelaziz, Kheira M]. PubMed PMID: 23233880; PubMed Central PMCID: PMC3518811.
22: Gomez-Cabrera MC, Sanchis-Gomar F, Garcia-Valles R, Pareja-Galeano H, Gambini
J, Borras C, Viña J. Mitochondria as sources and targets of damage in cellular
aging. Clin Chem Lab Med. 2012 Feb 1;50(8):1287-95. doi: 10.1515/cclm-2011-0795.
Review. PubMed PMID: 22868792.
23: Radyuk SN, Gambini J, Borras C, Serna E, Klichko VI, Viña J, Orr WC.
Age-dependent changes in the transcription profile of long-lived Drosophila
over-expressing glutamate cysteine ligase. Mech Ageing Dev. 2012
Jun;133(6):401-13. doi: 10.1016/j.mad.2012.04.006. Epub 2012 May 10. PubMed PMID:
22579812.
24: Vina J, Gambini J, Lopez-Grueso R, Abdelaziz KM, Jove M, Borras C. Females
live longer than males: role of oxidative stress. Curr Pharm Des. 2011 Dec
1;17(36):3959-65. Review. PubMed PMID: 22188448.
25: Garcia-Garcia FJ, Gutierrez Avila G, Alfaro-Acha A, Amor Andres MS, De Los
Angeles De La Torre Lanza M, Escribano Aparicio MV, Humanes Aparicio S, Larrion
Zugasti JL, Gomez-Serranillo Reus M, Rodriguez-Artalejo F, Rodriguez-Manas L;
Toledo Study Group. The prevalence of frailty syndrome in an older population
from Spain. The Toledo Study for Healthy Aging. J Nutr Health Aging. 2011
Dec;15(10):852-6. PubMed PMID: 22159772.
26: Gambini J, Gomez-Cabrera MC, Borras C, Valles SL, Lopez-Grueso R,
Martinez-Bello VE, Herranz D, Pallardo FV, Tresguerres JA, Serrano M, Viña J.
Free [NADH]/[NAD(+)] regulates sirtuin expression. Arch Biochem Biophys. 2011 Aug
1;512(1):24-9. doi: 10.1016/j.abb.2011.04.020. Epub 2011 May 7. PubMed PMID:
21575591.
27: Borrás C, Gómez-Cabrera MC, Viña J. The dual role of p53: DNA protection and
antioxidant. Free Radic Res. 2011 Jun;45(6):643-52. doi:
10.3109/10715762.2011.571685. Epub 2011 Mar 31. Review. PubMed PMID: 21452930.
28: Borrás C, Monleón D, López-Grueso R, Gambini J, Orlando L, Pallardó FV,
Santos E, Viña J, Font de Mora J. RasGrf1 deficiency delays aging in mice. Aging
(Albany NY). 2011 Mar;3(3):262-76. PubMed PMID: 21422498; PubMed Central PMCID:
PMC3091520.
29: Hernandez-Mijares A, Rocha M, Apostolova N, Borras C, Jover A, Bañuls C, Sola
E, Victor VM. Mitochondrial complex I impairment in leukocytes from type 2
diabetic patients. Free Radic Biol Med. 2011 May 15;50(10):1215-21. doi:
10.1016/j.freeradbiomed.2011.01.019. Epub 2011 Jan 22. Erratum in: Free Radic
Biol Med. 2015 Jul;84:386. PubMed PMID: 21262346.
30: Borrás C, Gil P, Viña J. Biogerontology in Spain: the most significant
studies. Biogerontology. 2011 Feb;12(1):77-81. doi: 10.1007/s10522-010-9314-3.
Epub 2010 Dec 14. Review. PubMed PMID: 21153917.
31: Caro P, Gómez J, Arduini A, González-Sánchez M, González-García M, Borrás C,
Viña J, Puertas MJ, Sastre J, Barja G. Mitochondrial DNA sequences are present
inside nuclear DNA in rat tissues and increase with age. Mitochondrion. 2010
Aug;10(5):479-86. doi: 10.1016/j.mito.2010.05.004. Epub 2010 May 28. PubMed PMID:
20546951.
32: López-Grueso R, Borrás C, Gambini J, Viña J. [Aging and ovariectomy cause a
decrease in brain glucose consumption in vivo in Wistar rats]. Rev Esp Geriatr
Gerontol. 2010 May-Jun;45(3):136-40. doi: 10.1016/j.regg.2009.12.005. Epub 2010
Mar 4. Spanish. PubMed PMID: 20206415.
33: Viña J, Borrás C. Women live longer than men: understanding molecular
mechanisms offers opportunities to intervene by using estrogenic compounds.
Antioxid Redox Signal. 2010 Aug 1;13(3):269-78. doi: 10.1089/ars.2009.2952.
Review. PubMed PMID: 20059401.
34: Valles SL, Dolz-Gaiton P, Gambini J, Borras C, Lloret A, Pallardo FV, Viña J.
Estradiol or genistein prevent Alzheimer's disease-associated inflammation
correlating with an increase PPAR gamma expression in cultured astrocytes. Brain
Res. 2010 Feb 2;1312:138-44. doi: 10.1016/j.brainres.2009.11.044. Epub 2009 Nov
27. PubMed PMID: 19948157.
35: Borrás-Blasco J, Navarro-Ruiz A, Borrás C, Casterá E. Adverse cutaneous
reactions induced by TNF-alpha antagonist therapy. South Med J. 2009
Nov;102(11):1133-40. doi: 10.1097/SMJ.0b013e3181bb554c. Review. PubMed PMID:
19864977.
36: Borrás C, Gambini J, López-Grueso R, Pallardó FV, Viña J. Direct antioxidant
and protective effect of estradiol on isolated mitochondria. Biochim Biophys
Acta. 2010 Jan;1802(1):205-11. doi: 10.1016/j.bbadis.2009.09.007. Epub 2009 Sep
12. PubMed PMID: 19751829.
37: Viña J, Gomez-Cabrera MC, Borras C, Froio T, Sanchis-Gomar F, Martinez-Bello
VE, Pallardo FV. Mitochondrial biogenesis in exercise and in ageing. Adv Drug
Deliv Rev. 2009 Nov 30;61(14):1369-74. doi: 10.1016/j.addr.2009.06.006. Epub 2009
Aug 27. Review. PubMed PMID: 19716394.
38: Kireev RA, Tresguerres AC, Garcia C, Borras C, Ariznavarreta C, Vara E, Vina
J, Tresguerres JA. Hormonal regulation of pro-inflammatory and lipid peroxidation
processes in liver of old ovariectomized female rats. Biogerontology. 2010
Apr;11(2):229-43. doi: 10.1007/s10522-009-9242-2. Epub 2009 Jul 26. PubMed PMID:
19633997.
39: Borrás C, Stvolinsky S, López-Grueso R, Fedorova T, Gambini J, Boldyrev A,
Viña J. Low in vivo brain glucose consumption and high oxidative stress in
accelerated aging. FEBS Lett. 2009 Jul 7;583(13):2287-93. doi:
10.1016/j.febslet.2009.06.019. Epub 2009 Jun 13. PubMed PMID: 19527716.
40: Matheu A, Maraver A, Collado M, Garcia-Cao I, Cañamero M, Borras C, Flores
JM, Klatt P, Viña J, Serrano M. Anti-aging activity of the Ink4/Arf locus. Aging
Cell. 2009 Apr;8(2):152-61. doi: 10.1111/j.1474-9726.2009.00458.x. PubMed PMID:
19239418.
41: Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A,
Borrás C, Matheu A, Klatt P, Flores JM, Viña J, Serrano M, Blasco MA. Telomerase
reverse transcriptase delays aging in cancer-resistant mice. Cell. 2008 Nov
14;135(4):609-22. doi: 10.1016/j.cell.2008.09.034. PubMed PMID: 19013273.
42: Borrás-Blasco J, Navarro-Ruiz A, Borrás C, Casterá E. Adverse cutaneous
reactions associated with the newest antiretroviral drugs in patients with human
immunodeficiency virus infection. J Antimicrob Chemother. 2008 Nov;62(5):879-88.
doi: 10.1093/jac/dkn292. Epub 2008 Jul 23. Review. PubMed PMID: 18653488.
43: Tresguerres JA, Kireev R, Tresguerres AF, Borras C, Vara E, Ariznavarreta C.
Molecular mechanisms involved in the hormonal prevention of aging in the rat. J
Steroid Biochem Mol Biol. 2008 Feb;108(3-5):318-26. doi:
10.1016/j.jsbmb.2007.09.010. Epub 2007 Sep 7. PubMed PMID: 18252241.
44: Viña J, Sastre J, Pallardó FV, Gambini J, Borrás C. Modulation of
longevity-associated genes by estrogens or phytoestrogens. Biol Chem. 2008
Mar;389(3):273-7. doi: 10.1515/BC.2008.027. Review. PubMed PMID: 18177268.
45: Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV,
Sastre J, Viña J. Oral administration of vitamin C decreases muscle mitochondrial
biogenesis and hampers training-induced adaptations in endurance performance. Am
J Clin Nutr. 2008 Jan;87(1):142-9. PubMed PMID: 18175748.
46: Vallés SL, Borrás C, Gambini J, Furriol J, Ortega A, Sastre J, Pallardó FV,
Viña J. Oestradiol or genistein rescues neurons from amyloid beta-induced cell
death by inhibiting activation of p38. Aging Cell. 2008 Jan;7(1):112-8. Epub 2007
Nov 21. PubMed PMID: 18031570.
47: Viña J, Gomez-Cabrera MC, Borras C. Fostering antioxidant defences:
up-regulation of antioxidant genes or antioxidant supplementation? Br J Nutr.
2007 Oct;98 Suppl 1:S36-40. Review. PubMed PMID: 17922957.
48: Viña J, Lloret A, Vallés SL, Borrás C, Badía MC, Pallardó FV, Sastre J,
Alonso MD. Effect of gender on mitochondrial toxicity of Alzheimer's Abeta
peptide. Antioxid Redox Signal. 2007 Oct;9(10):1677-90. Review. PubMed PMID:
17822363.
49: Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM,
Viña J, Blasco MA, Serrano M. Delayed ageing through damage protection by the
Arf/p53 pathway. Nature. 2007 Jul 19;448(7151):375-9. PubMed PMID: 17637672.
50: Viña J, Lloret A, Vallés SL, Borrás C, Badía MC, Pallardó FV, Sastre J,
Alonso MD. Mitochondrial oxidant signalling in Alzheimer's disease. J Alzheimers
Dis. 2007 May;11(2):175-81. Review. PubMed PMID: 17522442.
51: Viña J, Borrás C, Miquel J. Theories of ageing. IUBMB Life. 2007
Apr-May;59(4-5):249-54. Review. PubMed PMID: 17505961.
52: Markovic J, Borrás C, Ortega A, Sastre J, Viña J, Pallardó FV. Glutathione is
recruited into the nucleus in early phases of cell proliferation. J Biol Chem.
2007 Jul 13;282(28):20416-24. Epub 2007 Apr 23. PubMed PMID: 17452333.
53: Borras C, Gambini J, Vina J. Mitochondrial oxidant generation is involved in
determining why females live longer than males. Front Biosci. 2007 Jan
1;12:1008-13. Review. PubMed PMID: 17127355.
54: Viña J, Sastre J, Pallardó FV, Gambini J, Borrás C. Role of mitochondrial
oxidative stress to explain the different longevity between genders: protective
effect of estrogens. Free Radic Res. 2006 Dec;40(12):1359-65. Review. PubMed
PMID: 17090425.
55: Borrás C, Gambini J, Gómez-Cabrera MC, Sastre J, Pallardó FV, Mann GE, Viña
J. Genistein, a soy isoflavone, up-regulates expression of antioxidant genes:
involvement of estrogen receptors, ERK1/2, and NFkappaB. FASEB J. 2006
Oct;20(12):2136-8. Epub 2006 Sep 11. PubMed PMID: 16966488.
56: Vina J, Borras C, Gomez-Cabrera MC, Orr WC. Part of the series: from dietary
antioxidants to regulators in cellular signalling and gene expression. Role of
reactive oxygen species and (phyto)oestrogens in the modulation of adaptive
response to stress. Free Radic Res. 2006 Feb;40(2):111-9. Review. PubMed PMID:
16390819.
57: Mahn K, Borrás C, Knock GA, Taylor P, Khan IY, Sugden D, Poston L, Ward JP,
Sharpe RM, Viña J, Aaronson PI, Mann GE. Dietary soy isoflavone induced increases
in antioxidant and eNOS gene expression lead to improved endothelial function and
reduced blood pressure in vivo. FASEB J. 2005 Oct;19(12):1755-7. Epub 2005 Aug
17. PubMed PMID: 16107535.
58: Viña J, Borrás C, Gambini J, Sastre J, Pallardó FV. Why females live longer
than males: control of longevity by sex hormones. Sci Aging Knowledge Environ.
2005 Jun 8;2005(23):pe17. Review. PubMed PMID: 15944465.
59: Gomez-Cabrera MC, Borrás C, Pallardó FV, Sastre J, Ji LL, Viña J. Decreasing
xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations
to exercise in rats. J Physiol. 2005 Aug 15;567(Pt 1):113-20. Epub 2005 Jun 2.
PubMed PMID: 15932896; PubMed Central PMCID: PMC1474177.
60: Borrás C, Gambini J, Gómez-Cabrera MC, Sastre J, Pallardó FV, Mann GE, Viña
J. 17beta-oestradiol up-regulates longevity-related, antioxidant enzyme
expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade. Aging Cell. 2005
Jun;4(3):113-8. PubMed PMID: 15924567.
61: Viña J, Borrás C, Gambini J, Sastre J, Pallardó FV. Why females live longer
than males? Importance of the upregulation of longevity-associated genes by
oestrogenic compounds. FEBS Lett. 2005 May 9;579(12):2541-5. Epub 2005 Apr 14.
Review. PubMed PMID: 15862287.
62: Sastre J, Martín JA, Gómez-Cabrera MC, Pereda J, Borrás C, Pallardó FV, Viña
J. Age-associated oxidative damage leads to absence of gamma-cystathionase in
over 50% of rat lenses: relevance in cataractogenesis. Free Radic Biol Med. 2005
Mar 1;38(5):575-82. PubMed PMID: 15683713.
63: Borrás C, Esteve JM, Viña JR, Sastre J, Viña J, Pallardó FV. Glutathione
regulates telomerase activity in 3T3 fibroblasts. J Biol Chem. 2004 Aug
13;279(33):34332-5. Epub 2004 Jun 7. PubMed PMID: 15184392.
64: Serviddio G, Pereda J, Pallardó FV, Carretero J, Borras C, Cutrin J,
Vendemiale G, Poli G, Viña J, Sastre J. Ursodeoxycholic acid protects against
secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress.
Hepatology. 2004 Mar;39(3):711-20. PubMed PMID: 14999689.
65: Viña J, Sastre J, Pallardó F, Borrás C. Mitochondrial theory of aging:
importance to explain why females live longer than males. Antioxid Redox Signal.
2003 Oct;5(5):549-56. Review. PubMed PMID: 14580309.
66: Borrás C, Sastre J, García-Sala D, Lloret A, Pallardó FV, Viña J.
Mitochondria from females exhibit higher antioxidant gene expression and lower
oxidative damage than males. Free Radic Biol Med. 2003 Mar 1;34(5):546-52. PubMed
PMID: 12614843.
67: Sastre J, Lloret A, Borrás C, Pereda J, García-Sala D, Droy-Lefaix MT,
Pallardó FV, Viña J. Ginkgo biloba extract EGb 761 protects against mitochondrial
aging in the brain and in the liver. Cell Mol Biol (Noisy-le-grand). 2002
Sep;48(6):685-92. Review. PubMed PMID: 12396080.
68: Shaban H, Borrás C, Viña J, Richter C. Phosphatidylglycerol potently protects
human retinal pigment epithelial cells against apoptosis induced by A2E, a
compound suspected to cause age-related macula degeneration. Exp Eye Res. 2002
Jul;75(1):99-108. PubMed PMID: 12123641.
69: Sastre J, Borrás C, García-Sala D, Lloret A, Pallardó FV, Viña J.
Mitochondrial damage in aging and apoptosis. Ann N Y Acad Sci. 2002
Apr;959:448-51. PubMed PMID: 11976217.
Ph.D. Supervisor
- Juan Gambini “Efecto del estradiol y otros compuestos estrogénicos sobre la expresión
de genes asociados a la longevidad”, July 2007
- Raul Lopez Grueso “Importancia del inicio de la terapia hormonal sustitutiva sobre el
consumo cerebral de glucosa”, 2010
- Ana Díaz Cuevas “Estrés oxidativo y diabetes: papel protector de los estrógenos”, 2011
- Marya El Alami “Obtención de células madre de la pulpa dental. Caracterización y
adaptación a diversas condiciones de oxígeno”, 2013
- Kheira Mohamed Abdelaziz “Efecto del consumo de soja sobre la longevidad de
ratones OF1 machos”, 2013
- Francisco Vicente Bonet Costa “Estudio del estres oxidativo hepatico asociado a la
enfermedad de alzheimer. Efecto del tratamiento con bexaroteno y / o genisteina”, 2013
- José Viña Almunia “Obtencion y caracterizacion de celulas madre de pulpa dental
humanas e interaccion con β-fosfato tricalcico”, 2014
- Marta Ingles De La Torre “Identificacion de biomarcadores de fragilidad en el estudio
de toledo de envejecimiento saludable”, 2014
- Consuelo Escrivá López “Estudio de los valores de referencia para los parámetros de
estrés oxidativo malondialdehído y glutatión, medidos por cromatografía líquida de alta
eficacia, en humanos y animales de experimentación”, 2016
Invited Seminars and Talks
Over 60 invited talks or selected as oral communications at national and international
conferences and academic institutions including: The Physiological Society, London; University
of California, Davis; European Standards Committee on Oxidative DNA Damage, Valencia;
Gender
Medicine
Congress,
Rome;
International
Conference
on
Food
Factors
for Health Promotion -ICoFF2007, Kyoto; Grupo Español de Radicales Libres; Sociedad
Española de Geriatria y Gerontologia; Sociedad Española de Medicina Antienvejecimiento y
Longevidad; Sociedad Española de Bioquímica y Biología Molecular, Sociedad Española de
Medicina Geriátrica, Universidad de Valencia, Universidad Autónoma de Barcelona,
Universidad Complutense de Madrid, Colegio de Farmacéuticos de la Región de Murcia,
Ministerio de Ciencia y Tecnología.
Symposium and Meeting Organisation
- Young Physiology Symposium, Seville Feb 2005
- XXXV Congress of the Spanish Society of Physiological Sciences
- SFRR Europe Summer School 2014 edition
Editorial tasks
- Member of the PLoS One editorial board
- Member of the Oxidative Medicine and Cellular Longevity editorial board
- Member of Nutrition and food science, official journal of Nutrition And Food Science
External Reviewing Experience
- Grants: Reviewer of German-Israeli Foundation for Scientific Research and
Development (GIF), Agencia Nacional De Colombia,
- Publications: Reviewer for scientific journals including: British Journal Of Nutrition,
Cancer Chemotherapy And Pharmacology, Journal Of Diabetes And Its Complications,
Drug, Healthcare And Patient Safety, European Journal Of Nutrition, Gerontology,
Journal Of Women's Health, Journal Of Neurochemistry, Mechanisms Of Ageing And
Development, Plos One, Experimental Gerontology, Free Radical Research, Apoptosis,
BBA - Bioenergetics (Els), Cancer Chemotherapy And Pharmacology, Experimental
Dermatology, Free Radical Biology And Medicine, Journal Of Bioscience And
Bioengineering, Journal Of Cellular And Molecular Medicine, Neuropharmacology,
Revista Española De Geriatria Y Gerontologia, Age, Antioxidants, Redox Biology
- PhD Examiner: Participation in thesis viva voce examinations for Ph.D. candidate in
the University of La Laguna (Tenerife), University of Extremadura and University of
Valencia
Committees
- European Society for Free Radical Research council member
- Biological section spokesperson of the Geriatric and Gerontological Spanish Society
- Free radical group coordinator of the Society for Biochemistry and Molecular Biology
- COST CM1001 member
Hobbies
- Classical music
- Sharing time with my family
Dr. Borras can provide documents to prove all the statements included in this CV