#$"" %6 + $"% $"!"###((%&$# +++++++++++++++++++++++++++++++ 1 + $!"#&# ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 2 0+/+ $!"#&##%# +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 3 0+/+/+ 0+0+ (! +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 3 $!"#&#$!#+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ /. 0+0+/+ (! +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ /. + #$# +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ // 1+/+ # (! +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ /0 1+0+ ))!# +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ /2 1+0+/+ "+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ /2 1+0+0+ (! +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ /3 1+0+1+ $#"### +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ /5 + %"!$#+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 0. + 2+/+ (! +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 0. 2+0+ $#" ### +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 0/ "$# +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 00 3+/+ " ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 00 3+0+ (! +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 04 + $&%#&$# +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 05 4+/+ ")! +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 06 4+/+/+ "+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 07 4+/+0+ $### ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 07 4+/+1+ $###++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 07 4+0+ !"$ +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 1. 4+0+/+ "+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 1. 4+0+0+ $###++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 1/ 4+0+1+ $### ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 1/ 4+1+ '")! +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 10 4+1+/+ "+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 10 4+1+0+ $### ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 10 4+2+ $"++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 10 4+3+ $" +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 10 4+3+/+ "+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 11 / '(& # #& 9.8.5. $) #; (#'"#' ' .......................................................................................... 66 9.9. !(# ................................................................................................................... 66 9.:. %"(" ............................................................................................................... 66 9.:.4. &!# #....................................................................................................... 66 9.:.5. (#'"#' ' .......................................................................................... 67 9.:.6. (#'' '................................................................................................ 67 9.;. #* %&#"# ......................................................................................................... 69 9.;.4. &!# #....................................................................................................... 69 9.;.5. (#'"#' ' .......................................................................................... 69 9.;.6. (#'' '................................................................................................ 69 9.<. "..................................................................................................................... 6: 9.43. & " ............................................................................................................. 6: 9.43.4. &!# #....................................................................................................... 6: 9.43.5. (#'' '................................................................................................ 6: . (&#'&!#'#')'("'!% '" (&(!"(# # #& ........................... 6; :.4. #+"#() "/0 ............................................................................................... 6; :.5. "('!)') &' ................................................................................................ 73 :.6. '(!) "(' ............................................................................................................... 73 . :.6.4. " ................................................................................................................ 74 :.6.5. ## ................................................................................................................ 74 :.6.6. "('(!"#' ................................................................................................. 74 :.6.7. "(!(#' ....................................................................................................... 74 )"('#"') (........................................................................................................ 75 5 #$"" %9 #$#"#"$# "" "$"$$ "###$$# "/)"##%%$*#%##"$#- "'$ " #$%# # #/ # "# !% #$ ## "$ ##- "#%#### # "'""- $# "% "$"$"##$#!%&$ "/ %# " #$# "# % '" %# "# ) #%# #$#- #$ # % % #" "# "# # #- " - " " $#- %# %" #$" $/ % " ) % $ !% # ## ## % $"$"- #- # "#/ % " % #" # $ #$# "#- # "- % " $ "#' 12- % #"'" " " #$# %#/ %#%$)%'$ %#'""-#$""% ##$"!% &$%"#%/ $- # "# )%'$# ##$ % #$# #. $ # $# # ## # # $ " # ## "###/ ##$%##!% %#" " ## ##)%'$#. • • • • • ###-'*### # #- % #% %# # ' $ " # $# #%"# " " % %'"- " "%" $/ # "$ # ) "- !% % "" ## #%$" %$# 165 68 02 $ "#' $"# 1$" $ ( 2/ " %- %*$ "$- " %" $"- %"# "#$'%#'$#1" 2/ " #" %"$- %" #$" $ %" $ $- %"# "#$ "#'$"#1$" $2/ " " $#$## ## "# "'# % "# " # "$#$"#1($# "#2/ $"# !% # ## )%'$# # % #" $"$$ "- # "$$ $" "#$ !% #% #$ # #$ $'/ "- "%##$ "#'#""##( " -'*'#$-!% " "#%#/# ##$## ##)%'$##. • • • • • #"#%$## "#/ #"#!% #%$ "#"%##$# "#)#"##3 $"#3#"$/ #$ $%#"$##%"###/ ' " # " # $- ) $ % #$# $# % "%"##$ ##'"####/ ## $#%"" "#"$ "!% '#$ " "!%# "#"/ 7 ! • "3 " ! "' ! ! $ ) & ! " " ! " $ "&" !' ! ! + % ! " ) &"$ ! ! *! ),+" " "! ! &" ! % ! ! ! !+ ) " ! ! + ! ) % ) ! & )! ! + " ! ! " +! !) ! ! ! !' ) ) ' ) "! ) !!" ) "! ! & ! 0 "!0+ ! " & ! - - + ! ! $ !) " " " ! ! ! !$+ " ! ! )" #! "! " " " ! " " & ! ! " + " "! ! ! ! ". ! !/! !!) ! !' ) ! * • • •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• • ""!# !#!"" #"!" # ! !" ! , "!!!"!!# !, ""# ""% # " ! #" ! ! !#"! ! " !%! !+ • % "!#' !!94.;9-68 !*# !" ! 7 "! ! # ! " # ! " " #!"! , !! 11 # # !#!"!!"$594-68 !,!"#!# ! # ! " "", %' '* ! ! % ! !! "! !# !* & ! ! ! "!* ! !# 6-7 !!!"!"",!""! $ " !#!" " #"* !" #" !!!"744-68 !,:!!! *! " ! "# ! !!""" , +*(,/' +/*(-**)' +*(,/' +/*(-**)' +*(,/' +/*(-**)' ,/(/*' +**(,/*)' ,/(/*' +**(,/*)' " /*(0/' +/*(-**)' " +/*(,**' .**' ) ! & # -(. & " # ! " !* #! #" ! ! ! ! ! " ! / & " "0* # ## " ! "! " ! # ! !# ! /! * " "* ""0* ! ! !, # ! ! " ! " & ! " * & ! !# ! * " # " * * " %"!# ! !#, & " " " # " !"% ! !# *&#!#" ! !"!" ! ! ! !!* "! # # " !," " % " #""#%#*#"! : ,-+#'#'+ (.#'H +$';%'.%-',.%+'%',#<8%$+'6,$,$,(%6%,+ %#.%,','%,6)'+'%,.+,$%,-+%''%".%-$%-%,'# -',;)+,(% %,',< ' %.+'#)-', ;#'+)+'$2% ' #/')+'$2%< % )+,(% '% -(%8 %-' #', %,'# -', 1 %.+'#)-', )'+% +-++, )+'+,/$%- .%' , '%, # ,(%#'.%'',,$%,8 • #',-+ #',+*.+%%+ #-+-$%-''%.%',,+#-/$%-"1.$%-+)+'+,/$%-,- ',,%#6,-#%2+#'.%,$%#',,-+).-8-+',6 ##$', -$% =,.% %+(%=6 %' +*.+% %,)%,#$%- ,-).-)+'+,/8 •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• *.2#)+%)#+2(%)'+#*.#', )%-,'%'#'+1-+-$%-''%%-)+,/',%'%%',$%.1%# $(%,#)+(%-',,.%+',%,#,8 ,-',,)+,%-%.+%-#-+-$%-''%#$1'+ #',%-)+,/',8% ','%,6 ,'% ,$)#$%- $'#,-', 1 %' +/,-% $)'+-% # %6 % '-+,6 G &'%!!% • "(!6 &! #!%''& #% &( , #%!# * #'2 ! !&'(%%& &( ! , #%*"2 (& *& '! & &!#!%' #%%!!"$(&,*%'!&!%&(#!&#%" , & , $('! #!%'2 +#!%" % &% &(' #% '%(&'!&!#%*!2&'+#!%"&%*'#%&% &!&&!&,&'!&$(&!&%*%&#(&!'%''!,&' #%&'&!'%!%0*&!%!#%'#%!#!(%!#%&*!2 !&%('$(#'!!!%%"!&$(&$(! ! &(" !0 & #( #%% & !& %!& '#%&*!&0&!*!#!%'!!%&#%*',+&' *!+ ' &&!& '!& '!%!&2 #%!' & &% '!&&(%!&,!%'%!&,&!%!#%" %&& !*(&*&0 #%&!& #%&#(&'&2 &% ' ( #% &'*! , #!!& '!& %!*&(%&2 '%-!! , - &! &%!'!%!&&&"'!%2 !&&$(&'%!%&,$( %!&#'&!&'!% 3!!% (! %(%%' !% !#&!4 , ! ''& #%!& !&0&%&!&$(#%!#!'%''!'#%&*!&#(!%%0 &%&%!#'!1+#!%"%00!%,)&$( &!& %%'& 1 (! (! &'%!0 #%'%! #%!&''0 %!#'0#'!#',''&!*(&*!& #%&('!&(%!%#%(&"#1 o ''%*!%%!,!'%!%!!&&!%%&#!'&2 o !'%!%!&#!&&#!!'#%&*!0#&! %!&&&!("'!%2 &'%(!&#', !&%&1(#!%'(,*!#'&!&(!%%'' & &'%(!& , ! " ! & ('!!&0 #!% !&%% $(!&(%!$(&#%!(-('!'!2 !&!&%'%&'&0$(!&(%%&(#'!1 o #%!# '%" #%&*0 $( ' &% (%&! &! ! !-!&0 #%!!& & ! !& &*%!&0 , %&" #%!%&*0 '!! !(&#!*%&&&!&&2(&#%&!&&#% %&!*% &'(" #!!& & , ' %&! &' +#''*0 !'%''!2 o % +' $( ! #!%'' '%''! !!% &!!&&!&2*&0&#%!#!#',!&%&!&$( ','%*!%%(&!!'%!&%!&2 6 '(&""& #)"> 72"' ("'%)+("&$) $&")&) '"'('1'"&("")& ("'$&&"' '2 ' $&" %) ( '%) "1 ' '# &"1 '" " " '(&! ("1 " "'( ( '(' "'(' " ' )- (" "'" (&( ("2 ) ' $&'" ' '" ' ' ''%)"(&'('("'1%)$)( (& '$& "2 82 '( %) " $' ) "' 7637; '1 " $) &' & ( %) "' ("' '( " ("1 $"& " %) " & ("&"' $&()& (2 $&(& '("' 7637; '1 ' & " (& ""&$""$""2)."& (' ) "''$("'%) "(&"'1- "(&%)$. "&&"&"%)' ) (&"'(+"2'"') '!2'$)'"&'&'&$2 92 ' "'' %) ("&1 - ' "&' %) &"1 '" $ '' " &( ( $& " ) (&"''# $"&')) (1$ ' "%)&&"&2$""' )& ' ' $. " (&& "&1 " )& - 2 " '*( "' ' )' %) ( " "' $&"' %) $) ')&&1$&" ""%)$)(# %)' "2 :2 )& ( "' $&&"' ' ' ) (& ,'+ ( '" " ("1 $"& '& *( %) ' %)& )& ( 8 # 9 '1 '$& %) ' $"'2 '$)'1 & '$& " ' '" " 1 ' " (&&" ' "'-)&.'$&&.&')+ "&2 ;2"' "%)(&&7#8' ' $.& " (&&'"& (""'"''$("'2 " ("1 '( %) '" ")&&1 " $"' %) * ')&." '$ $&( ("&' # 2"'"(&"''"'%)'($" "') $&(("""$"'$&"&&-)&&'1$&"1 $&' ($"&%)'( &"1'')&.' 2"'%) "'('$"&%)%)&2'(%) "' ) (&""&1 "'$&")$1" (&( ("- "')$$"&'(&'1-%) "$ ')+") (2 " (" %)$ " (&&'"&1 (" '' '&"%) $" ') $&( ("" " $"'1 ' " '1 " %) "' '" ($" 1 '(&- "' " $"'1 " &"1 -) " ' (&' "'(' " & "' '1 " ) ')&." $"& +"+& & "' $&#"' " +& 1 ' ' & ') "'()&1 (2 (" ' "$&"&%)'"'')&."''" *('1-'' (&$&($(+""'$&"&'"'(&( ("2 <2)'$&'" ' " $'"$"&'((&# - ""$& %)'(&() &1$"& "%)$) $ '&%)"' ("' "'&+ '"1-%)' &"%)$" & ')$&(2",(&!' %)'((" "'# "%)'( "') $& "& '"2"&'"1-" & ')"- (&( (" "2')-& ( +&'"''')&%)')&&'' (&"2#"'& (%)')( ("' "&- " $ ')+") (2 =2 (&''( (&( (" "&""1 '%)&''"#'&)# ""+ "'2.""" # $"&' (&2 >2"')$&(&( ("'$"&)%)&&.# !&) "(&# 1$"&) &$1) # 1 (2 (&( (" ' "$( " (#("'1 '$& ' ) "(&"' ("' %) '(&" $& (&( (" ""&2 ("' "&'1 ' "(&" " $&'& ) (&( (" (&''((" "'(1" '*( "'- &"'"%)&2 ?2) "' ) (& 1("+&("&# $"&* ($"1-'" &"' ') " ("1$&") (" "'"&2 & (" '1'$"'%) "( ''"'(' ("' ') &"'1 ( "& %) " '& ')& (" " # )& ( +&' ' ''2'(# "')$&&'&)' (1$"&"%)-' &"&&"2 $'&%)( %)("&# )& (* ($"1 "'+()&'(' '2' "&&( (1(""' 1) +.')$&# ' " (&& (""2 762 " '*( "' )%)& ) %) ( 2 " " (& " "'"(&"' ) %) ' $"& (" "1 )%)& '$(" (&( (" '"& %) %)& '& '2 " "' 1 $ '&"' %) ' "''+ -%)(""''&&"'* $ $&+'("2 -"& $&( ' +' %) '( (&( (" 1 ' $"&%) " ' ')" "&&( ( ' '(&)" '2"'"(&"''"'%)$ ('$&&" %)&&)&&'-'&'(1$"&" %)( " "' %)')&(&( ("$(&2 o & ) "' &"' " ""& &# " %) ') )&# " ' $"'1%) '$)-)&-%) "( '")# 1 )'"$) ')&&'& ('$&'+'(&$"" &1)$-&) 2 ? !" o o #6 " ! " !%!!# !!! ! !" # !" " ( " -#! "!" #" " ## "!" !# !- ! "! !# ! " !+ " " " !#! (!- &!" # # "!' !+ #!" " !/# "!/ ' !- " +#" ! " #" !!" ! " ! ! !# '!"!## !" !! " " "- ! "% ! #!"! " ! " " " !+ % !! " ! $!# #%! #!"! + " #"!, • • •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• • • • • • +"+& $ ( +' $&+"' ) " (" $((+"1 "&. ""$"&( ("' (&&"'$"& '3 "&& " &'(&)()&& )(" " )("'( $ (1 &" ' (&$&'" '1$(# -& ("'"""&3 +"&&$&# ''%) +)"$"'- ")(.$"&$&"$" "%)" )&" '3 )"' $ (' " ""& ' #" & (&' (& "' " ("' (&$&'" '1 $&" '" $' $" & &" )('" &('" (&"'('()# 3 $& & '"' $((+"' )+"'1 '!& "&' ()# 1 (& %) $&"$" $ ( $) & (()' " "$"&( ("'3 ) $"'()&' %) '( 6 '!&6 " 6(& $& &6 ' ("" '" (&& " '$'(3 ' (&$)(' "$"&( ('1 $&( & "$"&( ("'-$& .' "$((+"'1$"&"(&"'$((+"'3" ""&$)'(&'$("1'" "" "$ (- ') ("& "1$&$&"$" &" )('"(()'(& (+'3 "'(& %) ' & ( " ("1 '(&'1 - ')' +&' +(' " ("1 " $ " " '()# 3 )"' $ (' " '( $("" ' ' ( " "'1 '"'1 " $"( (' $& & %)"' '$("' " &("' %)1 %)+" ( " "1 " '(()- ' ') '" "&(3(&$)( "$)"&'(" ) ("+&',(& '1 $&" +"&& %) ) (() $'+ - ('( $"& "(& (+ " (&"'()# 3 &&"' ("("" $( (3-$ ('%)". ')( # ' ("'%)$&")$ 2(%)&'1' ')'$&"'1("&3 (&$)( "' (&'("& "' '1 '$ ( $'"&"(&$1 " ( "" '# ')'(()& ' '' $&"$' +)"1 ' " (& %) '(' ' $" &) "'( "%)'" (&&'$"&$&"$ '3 "( ($"" ( # &'(&'-" ("&$ (1' "" ')&%) +)"' & (3 '& )(" " && ' 6(""'6 4$&"' $&+"'1 & ()1 '(&'1 ,'" (&"1 " ("' &'51 $&" &' ("( ( - & $ 6)("('"6 $'"'"#" $(""1 $) '& ++" "& (+1 '() ""' ) (#'& ('" ' " *( (" ' ' $((+'$&'" '3 $'"&"(&$"'(&'("& "' '')-+&1$"&%),'( *($' $&$&"' *(' " (&" ("( " $& "' )&"'3 '$" "' ) '$(&" ' " "' " &(" $'"(&"$"'1 '"("'1 $' +& 1" " (&"& '($(""3 • '( "- ("( ( '$."' (&( (" "' (&'("& "' ' 4&(&'(' $&'"&'53 $" "' + (&2 "&( - )(&(1 " + &2 "&(3 ,'( $ (' %) )(. &(*&"' 6() (61 " ' $ #("'1 89 *+)!%!%) • • • • • &,!%E (, *%## ,# #* "+ '%) ! *,$% 6%"% #*<5 #+)* #,*+)%*')%'&*+%*3/(,*$!)+)*',#+%*4 o !-#!#,&##0"+%9")%*%"!'+ o %!)#),0%#!%%!/ o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el propio médico 1. Relación buena, cálida y afectuosa con el paciente 2. El médico se siente confortable 3. Actitud positiva y realista hacia la prescripción de psicofármacos 4 Expectativas a priori de buen pronóstico 5. Resolución del dolor B. Del paciente 6. Mujer, edad adulta 7. Inteligencia normal ylo normal-alta 8. Carácter no-débil, indefenso o pobremente estructurado 9. Estatus socioeconómico, educacional y ocupacional, medios y altos 10. Casado; estatus marital estable 11. Etiología subjetiva emocional (vs. somática) 12. Expectativas y aspiraciones terapéuticas realistas y adecuadas 13. Baja hostilidad verbal C. Del cuadro clínico. 14. Nivel de ansiedad moderado-alto 15. Relevancia de las somatizaciones 16. Bajo o nulo componente obsesivo-compulsivo 17. Bajo o nulo componente depresivo 18. Baja o nula disminución de relaciones interpersonales 19. Cuadro crónico 20. Estrés precipitante plausible o reconocible (cuadro situacional) 21. Enfermedad médica estructurada concomitante 22. No menopausia o histerectomía 23. Tratado por el médico de familia o cabecera 24. No tratamientos anteriores con psicofármacos, o escasos y breves 25. Antecedentes de buena respuesta a tratamientos similares anteriores 26. Sedación mínima o moderada, buena respuesta global, experimentadas en las dos primeras semanas ! ! ! ! # $ ! " + !#"* " !" * !" #!" ! ! # !! $#* ! # !"# !$ " # !! "$ " !"# ,#/# /!" $ " *" !!" #"# !!!" *&#! !+ • • • % ! $ & $ ! $$ ! & !""! ! "*!# * $!!& #!" , # * "!! " " ! +!#*"$ !!! !-!%# * " . !#!# ! !" " # , " !"" $" !*# ! !" ! !* # !"$ #"!" " $ ! ! " ! !! ! & ! " " ! " ! !# # " " * & "* # !! " !!" ! " " , ! ' ' ! ! ! " $ , ' ! $! !"! " ! 41 & 351 #"!, ! !" # ! "! $ ! !" * " #* ' & '%* !# !" " #!# # # ! " & " , * !" ! !" $ , 25 $%## &9 $% #&! #$ % $%#&#$ #%$ %$. + %#$##$##!."&$%%&*#&% $%!#$#! 1#*(2#$& *%#$%%&$!!%0 %$* /$!&##$%#$#&!$$!&% ($% $& ( * $ !$$ % $0 % $ #$. $ $!#$&&%+ ##%0 %$++!$(%#!$&%# $ #!%#$ ##$!%$. & ! "& $ ++!$ &# $ %! !#&% $/ $ . %#( %# $$ * ( $%# 0 %#$ %#$ ($ ( %# !& !# & !#$ $ $$ %#. %#$ $ $ !& #$&%# $%#!&%%0 )$% & !#% &$ * $#!#$#! & %0 5:86 +! & # $ !#$#% $ $%$ $ !% $ $ $ #0 %#$ $% %. #%. !#%*%#$%&$%#"&+%$.&#$0$$$84$% %&)$%&$& $!#$#!$$%$$&$%$0$*"& $%#$&!$&$.$ !#!#%$!%$.$$!#!$$0 $. $ ! !## & !#% $%## # $ * $%&0 $ )!#%$ "& * & $#!#$#! $%$. &"&$&&$%#0!#$%#"&! $$ # !#$ $%$ #$ * &$ $ $ (#$ "& & !$ #$ !0 $$#$$/ • • • • • % $%/ $ # $! !# "& # !##%# $ &%+0 $ ! $%## #$ $&$%$ &% !% $% %# $ #%$ #$ #&!. $% !#)!#$!#$ #%0 ##%/$##$"&%!&$#%&% %#!&%&#$#.$$$$"&$!#% $&#%$ &$&#.%(#$$%#$0 %(&$(/ #! %# +! ##. $# # !## %#%% &#$ (&$$. $!% !# ( ($0 #+!. %# #( . $ #+ # )&$( & $% % #0%%(&$($%$!##%#$$& &$$$#0 ! %/ %$ $ #$ $% #&! % &%# $&0 & $ #( #$%#&%&## ##%# $ %#$#%$&.!#&$$%#$$$0 $# #/ $%$ #$ !#& & % %!# # # !+. # $ %# #. * #% % # #% !+0 $ $ !#$%$.%&%%($%# #!+0 %#$&%"&$$'$$#!++ . #& $0 $# % !& $&# 57 #$"" %> " $$%#/#"" ##)#%$*# $#%#$#%)#$%/ #" # " - % #" " " # #(/ * ) "* $ # #" " $- " !% # #$#-#"%$$ " %#$# $#/ #** #'"#%%($#)$$-$"# !% # ' "$ "#$ % %% ($#' ) $ " $/ ##$"# !% $ " # "$ " " "$$" #-%$" %$##&$ /$"# $") $ %$" "#"#$"$#/ $"" # 0 "# # ##$ "'# $"1/ # $# !% ( "$ " " % # 2 "'#$3- # *# ## $"$$ * - % $" " ( "$" # # %#- #"!%#$&#$"##/ "#%- % "# !% %$ # "# % '"# ## ##- % # $'# $" %$#/ %# ## %$"#"%$#$)'* $/$"#-%$#$ # %$" #% ) # " %#%"/ $- % $"#" $%"%#%"!%#%)$# $/ $"'%$$ "#"#"$#/ "- (#$ %"# "## # !% # ** # % "#%$"#/#- "#$"$# " # $#- %$"#%/ %$*%" 5:<;96 %#"%$- " "#%"$ "#"$#$ -)!%$"$$#"##%#%)5$"6/ # #" $" "% % # # #- ) !% % $" "#"# "$"!%#$#%/ $"#%"##!%#** # %#"$'# " ""- # # !% "#$ % $ # # %#%"/ #- "'"$"## #$" %- "# #%# " # "$ %#%"- " ""%'#"4# #4"/ # %$'#$ "$ % " "##"#"% #$" %$#. • •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• • • • • • • • •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• • • • $).*(!$) &$ %"4"#$)/""$ "(!)"+($!+)+ ()4!)*"(-)/ )*($!+)+ ( ()$").&+)*)()$&$*" 4$"+*$()-+ $)$!"&+ $() ")*(+!"*$)$!'+")(*$& ($5 "*)()&(*$($)4()$&()%"()&(*$( ) "0$0&") )$" (!$) * )+(5 * 0) $)) *(&+*)3 ) !$$") &(!*($) )$ %$)4 &()%" )"+"3 &+ )$3 ()&(%"3 &)$3 3 )$" !"!)5 &("& ()$ ) .)- )%" '+ &+ &($+() " $)) -)3$" $'+ )%"&+)(&(!($*$-()$/" !"*)*+%" ()$4$"+%"-+ $)5 !& $)*)+() )$($))""*"*$))+$5" !/$( )$) * ) )* &()"* $*( (+")*"4 $!"%" "0$0&") $" $*($) (!$) $ $$ 5 "*($ $) &(!($) / '+ )# (3 &$( )+ (+"3 *$ )+!%" / 5 " + '+( )*+%" " '+ ) $)(- +" "*") &()%" "*( 3/)&$)*+ +"$!$+)"*3))$)&( )$%" ,"$*($ (!$$ $$ 5 " +"*$ ) "*($")3 "))*() " $) *$() / )*+%" !*$ )!$&*$3 $)$)!)!&$(*"*)"+"&$) !$+ %" *$ "$ )$5 &)( "$(! .*")%" !& $ )*$) &)$(!$)3 &("& !"* $!$ +*$!%"3 ) "$") )*) )+)*") &( & ( )"*$!*$ $ $ $($) " )( !+/ &())5 ) "0$0&") (" *- " ) " .&(!"*%" "! :"$" / $ )5;3 $.&" !$ *- " ) !$("3/ $(&%.$"*$"03" +)$3 " )!$("5)!)!$3 &" / !0$ ! "*$"0" *- " ) $&$3 / (" *- " )6&()755 ?B &'%!!% "(!< #%&" 2%'!!&'!&!& !&&("*!&!%" '!&!&-!-#&,!& *&#&'!&'! ('!!&'!&&'& !&&("'!&!& -!-#&0+#'!!!%-#,!+-# 6+%"(%%7 %'!!&'!&!& !&#'&!&,!&'!%'(,!%((" !& %!&0 #!% ( '!&! & '! ! #%!# &!%"0 %$(% ( !&"&-!-#&*%2(!&('!%&,& !!% #!&'( " '%'% &&''' &'!& #'& ! * !%'0!$(%(%&#'%!!%-#,!+-#0!!&!'!&&" #"'!&&'%#('&2&'!&&('!&',!%*(%'!&#%"!&2 " '!% &'!& %!&0 #( &%1 !(&"0 #%&"0 &!!0 & $( !'%!& #'& , #&%& ( (&'" *(%,%'%%%!2 !& !&#(%&%('!&#%&2+&'#%#%!&!&$( & #%!#! ( (&! ' %*!& -!-#!&2 &% ('! &( &'%" , $( &'& &0 &( % ( ,!% !'" *%& #&!"&$(&!%&#!&&!#!%''!&!&!42 &'(" '!&! #'! & ' '%'2 &!& &(0 (, &#' #''& *% , %%!&&0 #%%%& #%&%#" !%-#(!+-#2 #&'%'&!%%&0'%&&&!&%&('!&(&'& &!!%0&&'%&9#!%:0;!&'%''!5&2 &'("'(#(%&(%&!&&('&#('!&1 • • %&!#&,!%!&&*&0&(#%!%& &&!! '%#('& , (! & ('- (%' ( '#! #%!!!2 % & #%&%#"#%!!&'#!!%'!&0(&'!&#'0&(#%!! 2%&!#&%!%!&%')%!&2#'& #'&0&('%0(&!0(&!!#!!(!'%&%!&2 &("!&(#%&"%(&!'%"&#!0*' (! & ('- & * !%' ! & &!'!& ! #"'!&0 #( #%!(% ( '! 3%!'4 ! &(#%&"0 %'%-! #!% ( %'! #%'&2(&'("&''#!0*!%%1 o ('!3%!'4!&(#%&"% 9= $%## &9 !#$$% & $% $ $&%% %# * "& #!#%"&*#%&## &/ o %#%&%#%%#&/ $ %#% !## $- & $!# (#$ #$ $ $# $&% !# !##$!# !&%$%%1#%2/$$ )!#!%%$/$%#%$&$-$%% $ $!##-$"&!&&%#/%##$$### %#%%%/ &# $% $&!#$ $%& ! # ++!$- $ $# $% #%'#$- $ "& * 5# #&+0/ #%#+ !# !#$ $%$ (%%($ 3%#- %"&#- $- !#%$ - $&# 4 * "&$ $&%($ $# &%$ %# - * $%$ !#$($/ $#% )!% #$- &$ * #$$ (&$($/ !# & !% !%%!%-$#%#+!#. o $$!#!#*%!%#%%!# o &%#%$$!#%#&%%#!&%3%#4 o #$#!$#%$$ o %$$%-&$$&!#%#%% o $%#$$!$%##$ o • • #%#$(& $%%#%. • • • • & !# $%$ $&!#$ * $ %#% & !% "& $% % $$ ($ * &#% %! !#- $$!#$ & #!# $%%$$%#/ & !% $% % ++!$ ( #- &#% & !# %! )$(% !#- & $&!#$ #&$ !& !#&#$%%#%$&!#$ -&$$%$$$$!&$/ $&%+++!$(#%-%$%%#%!& !##$#$$&%$$&!#$ / ( # * !# $%$ $&!#$ $ #$ $&%$$&$& #%#-$$!#$&%!$ / !%% $&$ !$ ! !$"&%#- $ &#!%$ %$ %!$ %$ !$ #%$ $ "& $ '%$ %#%% (#$$ %!$ #/ &#$ #$$ $ %#$%#$ %&#+!&#%!$"&%#3$"&+#4-#%&!%&%# !#%%- * # # !#!# $ !#!$ $%$- $%$ &#!%!/ !! %& "& $%$ %$ % %#%% #- &* &$ !##$!$"&%#. 87 %&$ $ • • • • • !' ; %'$ "& %" %'&(%"$ ".#'%" %& )"$&! * 0 %&$ &( % $"$ .'&+ & %*%"%%$&%0 %&$ &( % "$ " "$ . %& )&$$.*#'' & " $%%7<:;."$& %&$'&'$#' "$0 % '$ "& % "' '&+$% &$&& $0 ( "$ '%&$'& % %$ $0 %%86% "$%. " &%.76 $3%* %040&$ %' %'$ "& % "$%& &( %. % % % % " %0 * %0 %$ "&% & % "%%. &$% ! "$ . %'*$ "'&& %'% %% " %0 %& % '& $% $+$ ' " %&$ $ %&' %&$ %& "$ . $%'& % "$ & $% % %& & $ %$0 % '$ "& % $& '$ )&! " #' % "'% % ' $! $&'$ 3' * %&$40 &$ " % % " $$%" $ %' &'! % $ "%#'% "&0 % '$ "& % "$ ' (' ' %& $ ." $ . $%'&! "%$#'%&$%)&%(%& $. %& &( #''$ $ % "$ '0 ! % "' $%" $ #' $"& $% "$ % #' "$ '%&%%'%&%.'#'' % " %0$ . "$ '%&$. '%&$% % )"$&%. ' & % "$ %1 * % % "+ " &$ & % $0 $ . %'"$ ) %& !. " & " 0 " . #'& % %" $"& $% "$ % " %&%"& %. & + $ %& % $0 % %& % % "$ $ % #' #' $"& $% "$ % % $%" %. % $ "$ $.& % #' % '"0 "$ %&$ '&$( %%#' %&$76*8:' "&&% %&$%."$ '%' .(%%&'"'& ) & * $' % " % )&$"$%0 %& "'& &$"'& "$&#'%"'$'$ $%&$! " %.%'* %$% %!0 %& %($% %' %'&+ %'$ "& %% / • • •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• • •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• • o $ -&$)+-.+&$,$9&$+8 o :&'+ -$6&3' 3) &,; o & &$9:0 -+ &; o & &+)- (&:- &; o )&- &:%/$- )$,%& ,%',&'-'-$%&-,+ -',; >A ,-+#'#'+ (.#'I #'*.%)++%-$%-#1-(%#,#.#,*.,+%'+$ +)--02'%.%+.%#-=%-' %7+$3)%7'0#)+''7 #$'-+%> o )%-%#'*.%#,#'-)' o • ,)'% $)# 1)+% % # .,' #', %-)#)-', #,',7 ,)#$%-#',-+,$2'+$)'+-%=%-' %7+$3)%20#)+'-'>:, -'', ##', $.,-+% .% ,$#+ % # '%-+'# # '#'+ +'%': 2 ,-.', *. '%,+% # +$3)% '$' #' $, ,.)+'+ )+ # '%-+'# # '#'+ # %+0' -+$%': # )+%)# )+'#$ *. )+,%-% +% )+- #', +$', #,',7 )+- *. 1,- .% +.)' )%-, +$'<+,,-%-,7 , ,., +-+ ,-, +$'%-,9 "+% .% .+- %.(%;%(% # ,,-$ -'+'$' EFA =.#-, $%"' '-+', $$%-',> 2 , .%% % +% $ )+'- %, )#,$-,7)'+#'*.-.#$%-)+,%$'%-'+3(%#',%0#,)#,$-',: $,2*.0#+)'-%#,+'%,0+,,$-'#(,7)-,2.-%,2 ).% -%+ -', 0+,', $)'+-%-, ,'+ 2 '-+', ,,-$, =#-+'%, '+$'%#,7'0+')'#*. ,-'+#'%''%0#)+'-'7',-')'+',,7-:>'%#'"-0' ,',#2+ ,-, ,0%-", 2 '++ .% #-+%-0 , +.)' )%-, *. %' , '%-+'# '% # $'%'-+) %# , % ,++'##' #', %.0', %-)#)-',: ., )+%)#,.#,,'%.%+$'%-$,(%2#,,.%(%)+'- %,7'% #'*.,#-,.$)#''%".%-''%'-+',+$',:$%,'%$%',+.%-,#, +'%, ',%+,, +0, 2 %' , )+, .% $'%-'+3(% %0#, % )+$-+',$-'#(',')-',=,#0'##$-'>:.,0$%-$',,).,-' -+%7 $'-+% 7 #$-' .2' .,' . +,-+%' ,'#' .% &' ,).,7 )%-%7%7')+$-'70-+-$21+3)% ',+$',%-'%0.#,0%-,7#%-' %2#+$)%,'%)+-.#+$%- /-#, )+ # '#'+ #+%-: . $%,$' (% '%,,- % # ,.)+,(% #', ,- $.#', %+0',', %'+$#,7 '$' +,.#-' .% #,(% # -"' %+0',': +$)%,#+$'#(%)+#'#'+#%.+##-+$%'=$+% % '-27 BJIH>7 )+' 2 ')%'%, '%#-0, ,'+ # #(% +$', )+ '-+', , %+'$, '#'+',', %.+')-',: % $.', )%-, # '#'+ ).%3%- -% .% $%,(%'%#*.$3(%''#'+$%-':%#.%',)%-,,%'%-+'*. #-+).-%-'%0.#,0%-%',-0%#'%-+'#,-'$)'%%-#'#'+: %,-$'.#',+0,%#,%'%,%#-+-$%-'#'#'+7#.%',#', %.0', %-)#)-', , $)#% % # '#'+ %.+')-'7 )+'#1, %-$+&', 2 -+,-'+%',),*.-+','%.%.,'%#.,'$.'$,1-%'*.%)#),: '%,+' *. , $, -' # -+#', '+$ %0.#3 )'+ #, +-+ ,-,,) ,.%'##',: +$3)% , )+'( % #', ,-', %', )+ .,+ '$' %- %-)#)-' % BJHE: $)# , # BJGA )+ -+-+ # %.+# # -+$%' =#'$7 BJGD>: +$3)% -% +#(% *. $ '% #', %-)+,0', -+ #',: , .% +0' # $%',-#%' '% .% +.)' +$#' % # )',(% F8 ,- CI ()' # #' $* #B '$" ( (" %' *" ), ")% %) %#)")4 -() #"(' (*%'%#($"")' (()'*)*'()'!"(#" ( ")#". '!/%"4 #()#(")#",* (,#( '!/%"" #("! ((%'" #( ")#"4"#"")'#"()'%*)(2 '!/%"%*"' ('((!-!( )'#(#2.# ' (('(" (# ("*(%#' % $" # %" "4 !( ( !( / &* ")#" %' ,' *!' ( '(( !"!( %#' )'#(#.%' #&*''(("'(%*() %") "#))'/# 4'*%%"*"$&* '!/%" )" %## )# "#' (#' " !* (%" )#4 ( #"( )'#(# $( . #&*!( '(%#"( ( #( )#( ")#",* (,#( (#" (#"#(4 '!/%" ( (#' '%!") (%*( (* !"()'$" #' 2 %'# #" '" ,' ",* 4 ( #"")'#"( % (!)( !-!( ( #('," =6@ #'((%*( "()2 *"$"#" (%'#)"(% (!)( B;F4!)# / <;2<<6%$-#2 . () #!%*()# )!" )" ), ")#",* (, . (* , ! !"#'&* #!%*()##'" 7?6B#'(84 ,!(<><A#'(4# *)#"*$" !)# (!# '#2()(!(#')#&*" #(",*#(&*" '#*"(# #((4"#( <F '!/%"('*%'" #'""#'! #!%*()##'" # %$-#4 !)# (!##")"+() '!/%"6<;2<<6 '$-#. #"*$"#"# **'$"#4 " *." % #%2 ,($" #''#(2 (#!"# "2 !'#(2 "*((2 ,$!)#( . )-4 !" ( #(',# '" ,' #)'#( )#( (#' 2 ()'#")()" (2 '#,(* '( . '!)# $#(4 )'#( )#( ,'(#( . %'*#"( (#" (!")( #( #(")%')(,#()' #(4(''# '))# '" #()#((,#' (2 . %*" !"!/'( *!")"# '* !") #(( . *()"# #(( !")"!")#4 '!/%" *(# !*')( %#' "! % ( . %#' )#( '#,(* '(2 %'# ( *" '# , #(4 #( )#( ,'(#( ('#(2 !( %'($" !* $(2 " *." *#%" %+'%*' )'#!#)#%"2 )' %)# * ' . # ())2 # *' * #" %')"($"2 )'#!# )(2 "(*" ,")'* ' /&*' . # %(# '#,(* '4 . '*%$" *)"2 !"*# #" #)'( !"()#"( ' '#2 " >F #( %")(4 !(2 ("'#! ),"(6#"(#"2 '!))( -# ),2 #)#("( 2 )'$" %!")$" *)". *%*(')!)#(#(()!#4 )')!")# # #'%' "*' )'!"##!"/#"*"#((=;; !%#'3()*!")'('* !")2(+"("('#2()*"", <=;; !%#'( !(!#()# '4 # -() *" ' $" (!% ")' #(( '!/%" . ( #"")'#"( '#" % (!4 (#"")'#"()'%*)((()!""@BG5! 2*"&* -()" ,'#"(4 #( )#( (*"'#( )'* ( (#" '*")( " #"")'#"( B2? <; G5! 4 #" %#( ( ")'#"(4 "#') *!") !)# (!# '!/%"3 #)'"(#'!$" ")#"%**!")'#" 4 =C *+)"%"%) &,"%B $+)%,!% $ " #)% #,$" $ =CCA 0 * ,+%)1& $ " $% $% %#% +)+#$+% %0,.$+ $ "%* '$+* %$ )** ')"*3 %$ % *$ $)"1&$ *,$)6 "%')#+%*,$$,.%$+%$.,"*.$+-"+#$)&$3%$,$*+),+,) (,# )$+ *,* $+*%)*6 ) +,) "%(,$% "%* $"* 0 %$ &$",+#+)0)0'%)$&$"**%$1#*$)*)&$ +'%06 * ,$ *,"#+% ).% " 8),+%*6 $ #-"+'"* #$*#%* &$5 "%(,$"**%%0"%'$$+*.%"+!3),)1"+."0* ,$$+%$*+",+#$)%6*3#*3$%)"$)*)&$6 *%)&$%)"*)'0",$&$')%+$*#,0!9#$%)"=AF:6'$* 0#+%"*#%'+%0"B<F*"#$'%)%)$*$#%)6,*#.*><8?< %)*6 )* !,*+ %** $ " $*,$ )$"6 *#$,0 "%* $."* %/$ 0 *+)%"3 '%) "% (, * * #$*+) %$ $+%$'+.%* %)"* *+%* $ %$+$) " #$%* A< #)%)#%* *+)%" 9," (, ,$% * #$*+)$ % :6 )%"#$+*+-"+#$+)&$*'%%*$+.%$%**#$%)*><<#76 %* *+,%* "+)%*%"&%* 0 %(,#%* )"1%* $ ,"+.%* $,)%$* *,)$#-"+'"*#$*#%*&$*,$+'"'+5 • • • "%(,% *+% '$$+ "%* $"* " *%% .%"+! '$$+*3 ),$%",)&$"**)*'"'+%)#*0"$-#)%'%+$"* &$$)%*$*)6 ,#$+% " $&$ # '%) " 3 '%) *, &$ $ "%* )'+%)* 9:(,$%*%$#%,"%*'%)"%*)+-)%*$"*6 $+%$1 " +.&$ "%* #$%%* /+%)* %$*+* $." )'+%)**'%*$%898#+"88*')++%: '*)(,*+*,*+$$",$**%$1#*"$)*)&$3*, +%*#*"(,""+1%"#3'%)"%+$+%3$%*)*,$%"%*+%* (, %$+),0 " &$ $+'"'+ " #*#%6 $ #)%3 *+ $&$ ', /'")",$%"%*+%**,$)%**%%*%#%"%)#&$","%*)$"*0 "*')*+**6 *#."#$&$'"*#+$.)%$**$%*+)+%*%$A<#%=<<# ,)$+ =@ * * >= %)*6 $ #)%3 " %$$+)&$ *#$,03 $ ,$ A<F " %#$)"% %$ $,+%)* $1#+%* %#% " $+%$ % )#'$4 " *#. "#$&$"*)#$*+)%%#%+)+#$+%0,.$+%$$,+%)*$1#+%** =>8=A%)*$)#$>.76 ?< '(&""& #)"A ""(&( ("",)* (0' (&& =993*"' "'("'2 ) "'$ ('$) &'$" &" ;9932*&") '"'' &)'( -&&'$)'( #$(2 '(&&;>4>93'( "''(*" & ("'' '"' '>93 '()"' & (' ' ") " "' ') (' &')("'1 &)# ' (*""&'$" ( "5@=2<E60" ((5==2<E6" "'' (&:;2>4=99 0) %)'0A?0 "$&# " '"'' ($$('2 " )&"$(""&"'('$") "''=993 )& ( B ' ' , "' $ (' $&' (&" ' (* ( "' ""&0 " $) ()" ' )'(" &"546 "&'2 )&& "')(-") "'':@>3" ) *" ( '" " "(&$, (&$" " &$ 2 (&( ("$&"("&!&# (&("''$ )BA35=B4;99362') (")B' ',"'&')("')&" ) >?E"&2 (&( (" $&"+' &! '*& " &# & ' )(-&" "'' :99 32 &'$)'( $"'(* ) * ( ' A4:9 ' ' "( "'?9E"&"&"$"&( (2 ,"& "' ("' *&'"' $& ' ?4A ' ' ' (&( (" , )& &# " "'' , *" ' '"2 "' ' &) (' '" $& $'" 5;94<9E6 , "&+ , ("' '"& 50 '("0 ("&0 '" " , )(' ) "' )("'0 $&'# 62 (&"' ("' '" $&'('' , "&# )"' & ' 5:0>E00'"& ("" $ (' " ( (' &"(''$"&"%)'"$'&'')$" '("''"'60 &"''0 $&(&0"$,)"2 <: ()'##' $*#@ " (*!)#',#' /%!3 !( #$!(( '()2 #&*!#!((##%!!)(,#)3%'# #*!' #)'!),# ' /%!2#! !#()#(,'(#(*3 " #(%#! #' ( ) ! ) !) ( #!,') ! (* )#)# ),#6*!:95 #!#'#-',#7&*(*!!*!=9C%'#)!(%( )(3* )#( # ( %)#2)! (( % !#' (() )#'# # =>9 %'# !**!(*'*%#!/ )#()(() 2<2!,#*'#! )#( # #( !)#!%),#( #'(2 %#' # &* ! !()''( # %*()#( #! *! #!)!# ()'#!#)#6 .#'>9 '#' #(()'#7%',)'#(! !)#!%),#3 '! ' /%! !# *)#!* (* )#( #3 '( *()#((!!(*!'!3 " #()#(,'(#( ('*!)((#!#((%!!)(.)!( !) 6($!2 )-2 %#%2 !*((473 # %'#* *#%! ! )'$! #)'#( %' )'#( )#$#( %'# ( ( !' !) '(# %#!)' '!) ' /%!2(#')##!!!#(3 ('#!(*)!(%'(!() ! (#! !#( '*!)( .2 ! )#'2 ($# ( %'#*! ! *! )'# #( %!)( &* . !%'(!)#' /%!3 " (*! #*!#3! !'(),'','( )'!( !( 6!' )#/' 7 %#' # &* * !) (* #!!)'$!3 (#'$!#'('%2!#(*!%'#)!(%( )(.( !((! #'! #'!3 *%'!%)#(*!'#2&* )#-)!(, !)(**(#2('(# %' %#,(*&*(*!:?5=9C#(%!)(3*# !/')'(,'#( (( !# )') !)# . (*%#! *! '()'$! #!!)' %# ,(* &* )%''!) !)#( %#(!((2))'%#'#()&*)( (,'#3 ! '/' % )'( %'$( #!)'# )##( #( %!)( # &* '(*) *.!!"#(%&*"#(3 )'#()#((*!'#((#!* !)#%(#2%'($!.%(#((3 "! ( *! # %*()# !)'!# )+ #&*!# !( (## %!!)( ,#) 6# # !)#! . ' /%!7 %'#2 (#' )##2 ! *( %#'/(2 #! # <; *+)"%"%) &,"%C (, "+) **#$+ " +. *%"& "+) $%)#"5 #0%)* %$$+)%$* +-*%)"%*$"*"%*#$,0$%"")&$",+#+%5 *%) )'#$+ 0 " ,$&$ ')%+$* '"*#+* * " @@6A;F5 #+%"1 '%) ",%)%$1&$ '+ 0 *, *#. 7=?6>@ %)*8 * . #,0 $", '%) %+)%* )#%* 7<? %)* %$ $,+%)* %#% 0 % *+ B; %)* ,$% * #$*+) %$ % ."')%%85 % ')* !,*+ %** $ $*,$ )$" 0 * $ $*,$ '+5 % "+) " $+%$'+.%* %)"* ,$(, *+%* ',$ )$*)%$)#$+)"%**")#%5 *+$"#$+$%#%+)+#$+%%0,.$+$"%"%)$,)%'+% $,$+%"%*+%*.)*%**,$)#%%$**%+%*$+0*%)" ,$&$%$+.$%#')&$%$%+)%*5&$*%)#'""'%*" "3 #)%3 +/3 '"%'5 +)%* +%* *%$ +'% *+)%$+*+$" 7$%)/3 $,**5585 ')%/##$+ " <;F "%* '$+* *))%"" ,$ )* ,+$%3(, ', *) #,0 ). 7$)%# +.$*6 %$*%$ 0 $)%"** ')# +&/85 " )* * " ')$'" +% .)*% *+ )#% 0 *, ),$ * #0%) * * $ " +)+#$+% %$%**".*%%$,$*"%%**)'%5 * ,$ )#+% (, "%(, $"* *%% 0 "% .%"+! '$$+* 0 $+%$1)'+%)*6#+"66*')++%785 *'%$" %)" * ".0 * ,$ **#$+ ')%+$* 7=;6=@F85 * ,$ '%+$+ $%) " **+# '+% ?@; %$ "% (, ". "%* $."* %+)%* )#%*3 *'"#$+ 3 ,0 %** ),)* $ ,$ =;6>;F * *#$*+)$ %$!,$+#$+5 0**/')$$"+)+#$+%"%"%)5 %* +%* .)*%* %*$)*%* *%$ "%* #* ).*4 '"* #,") 7< ?;;;6C;;;8 0 '+%+%/ *.)5 %* +%* #* ),$+* *%$ ".* 0 %$**+$ $ #%"*+**+)%$+*+$"*3$%)/$*%#$%5 *,$#%","$"%",$(,*,+%+)',+%$%*')%,%#% %$*+)%0$%*%$%$*,#$*#%&$5 >> "#!! $: "!!"!'""""#$ $ !""!#!5:44.!$"#$!"$"!#"#- " $ !#" "#" !$ $ #! " (" !""#"-&!"!'""$!! $!$"# ""-#!"$"""##!#!## !$!#-&!$$!%!"" $ " # "" " #" 05644/7944.1 $" $#(" " "'" ""- "#"%!""""""'""#","+!+#& !# "- " "!# !" %!"" !%" "!""- ! ##+ " $ ! $" !#!"#" !#" "+ $" #!"#!"!"+"""#""$!"- "!%$"!"$#"#"""944+'%"" 74405"$.-1- ""!"$!$!(#!"#"+ !%'"""-#!#"$+"'!!( "#$!!'!#!#!"!"+!"##" "$!" , ## 0"1+ "+ "#+ %!#+ "+ ' "#-"$!#'#"#!- "!""", • • • #" $% "#+ " $ # " !! !,;446844..#!""" #!#%#!$#,5:447944. $!"%!"##",68448:44. 78 *+)"%"%) &,"%A %$ $."* *)%* *,')%)* =;F8#" ))#$+ ,#$+ " " )#% ,$(,*"."%**"#*#%7 , +. $ " ".% " %"%) * #%*+)% "$#$+ $6 ,)" %*+)'+5,)%'++5*")%**-"+'"5%"%),)%'+%50*,+"1% %$+%*.%)"*$6*+)%#'+%"!5)+)%#"5,)%'+%'+" +)#$%5,)%'+))0$)%#%"%)$+)"7 $#0%).$+!"*'),*')"$**(,5"+%"'$+$$" %"%) $,)%'+%5 ', *) /#$% '%) *$+%#* $.,"*5 +"* %#%6 "%$5 ')"*5%"%"%)*'%$+$%7 %*+,"**+,%*"%)+%)%%$'$+$$$(,6 • • • $%+",#)""%"%) *+.$"),&$"%$')"*7 ',+$),$+%*"+.%$"')%*%$%'+.% Neuralgia Postherpética Controlado ==B 3600mg Mejora VAS Dolor Neuropático Diabético Controlado <@? 3600mg Mejora VAS Esclerosis Múltiple Abierto =< 1200mg ,&$%"%) Esclerosis Múltiple Abierto =? variada ,&$%"%) Dolor Neuropático oncológico Abierto == variada !%) Dolor Neuropático central y periférico Abierto <A 2400mg ) Dolor Neuropático Diabético Randomizado =< 1565mg ?=E)*'%$ >? +,*"&"&* '-"&E +,##$,&+$-$,*$-+&$-*&(+>FC=1+>FDE$6 - #$+#& '$ + ,*/+ " -#$,& " &$$,*'$ " & #8#$&-,*&9:6 " & /"(*&& "/ "+ &$$,*&$+ " $-*&,*$+#+&* $&*5&#&&$+-$"$'$"#,&"+#&"6 " & /"(*&& (&+ -$ +&*'$ *( (&* / &*" &$ -$ &+(&$" (*&0# E= I6 " (& &$$,*'$ ("+#, + &+*/ $,* > A &*+ 1 + *,* &$ +,'#& ""$&6 " /&"-#$ +,*-'$ + $-$,* $,* =5> 1 =5A "7!6 &$$,*'$"/"(*&,&$("+#&$,&,*(-,&5+,$,*B=1>==-7#"6 " "+ (*&,$+ ("+#,+ $ -$ F=I6 &$$,*'$ $ " "$2 " >=I " ("+#,6#,&"2$&(&*&$ -'$5$#$&*#(&*&0'$1(&*" ++,#,&*&#&AB=?F60*,(&*&*$5+1"#,*$6-/# +(*&0##$,>B&*+6 &+(*$("+,&+/*+&++&+*/$$"(*,&+,*&$,+,$"$">CI "&+ +&+ 1 &$++,$ $ $&*05 $-++5 /'#,&+ 1 **6 $ " (- /*+ +'$5,01,#"&*+6+*-$,""/'$"+,*$+#$+++,$"A=I "&++&+$&*#+$,&#,6 ,$*-&$"+#*2+5(&*)-+*(&*,&#1&*$$ ,&+ " ,-& $-*" $ $%&+5 $ ($,+ &$ $+-$ (, 1 &**6 $ ($,&$(*+$+"&$&"##$,&6 -(*&-*(,&0#&*,"5(&*"&)-$,+$*",*,#$,& *+-$/"&*'$-$&$+(,+6 #("$"&"&*$-*&(,&6#$+,*(&*/&*"6 &++$"+>B #7!7 *(*, $ ? & #+ ,&#+6 $*#$,&+ B8>= #7!7+#$5 +, "&** " &$,*&"+&"($,6&++#0#$,*?B=8?===#6 +&*&++ (- (*&-* +'$ & &#6 $ +, +& " ,*,#$,& + +&(&*,5 #$,$* -$ -*++ -5 /&** " 0*'$ " *#&5 " "/& +,*&+(&&.,"&"*(+&*'$"6 "&/"(*&&(&,$"'$"&+*#&+(*+&*+"6$*#$, "&$$,*'$"$&*,"+,"A=I-$&+#$+,*+#-",$#$,5& "*-'$"#,&"+#&"++,#?F6 ,&0$,&$(--#$,* $ +& #$+,*'$ &$ -$, (&* " #+# *2'$6 -$,& &$ " "&$2($ (- (*&-*+ -$ +,& ("(,& -+$5 $&+ /,* +- #("& +#-",$&6 -#$,"'$+,/"2(#6 @C '(&""& #)"= !)!'(&)()&%) &"!"!"!$#("-(*!!" &$(#! ! ' '!$'' "! " %) ) !( "!!(&#! $&!$ !)&"(&!' '"&!"&1 " " ' (""' "' ' !($$("'0 '"&#! "& ' &$ )!%) ' + ' ' "&( 2 !'(&&' (&' +' 31 )! ! ' >:A $&"(!' $' ('1 (#". ! " (&+' !. 8 ("&" " 9:6 2$&' &)& "'' ! !')! $(3 )!%) !" ' !"& ! (+ "' ''( '!. ("' &"'" '1"'''!"!(&"!"!!("!$(+"'"&'1 $ ! $"(&$ "! !#! ! ""& !)&"$("1 &"' '()"' ! "'(&"')!'('!("0)!%)"!&')("' "'("'1 &" !!"'("'+&'"'($"!)&"#"2 &"0( "&0)(! "!!(&#!3-$'%)(&"2&&(0$&'#!0$'"''3!'$& &'' !'-'"! !"&')!""'''&$&(!(&'")(&"(" '1!)!7A$&$"("!"! )')&!(!'1 "'!'&("(&"!' $"+')$&"')!"' '"'!"'%)'!!")!'(()'$$("!""!+)'+"1 ')! ")'(&)()&!"& !"-'&&"!')! &! ,(" %) (!" $!(! ! ')' !"!' !($$( - $& (&( !(" ""& !)&"$("1 &! !( ) & " " $!(! $& !" ' &'' $$(' !&.' " $&' &''(!(' "' !("!+)'+!(' (&"!'0 $&" )" ' "'&+# - $"'(&"& !( ' " $&"# !( !'-"' $&"$"'0') $"&(!(! !"""&!)&"$("-!""&"&! ! ("&"1 +!$)&!( !("!& ')!(&( !("""& $&")" $"& !)&"$( (0 - &) $&' (& - ! ! "' ""'0'#!!&+"'0""&!'"!0""&! ("&"-'#!$"&"& !1 )'"&#!$"&+"&'&$0"!)!"'$"!B>6A-(& ! )!)&+!&0 !&%)"'("'"''"!!(&#!-"''&'$)'('"! ' $&'!!&1"!"!!(&"!'$' (' , '"&1 ("' "' !'!!(10 !!"' $"& ,&#! &! 0 "! )! ' + !#! ;18 "&'1 )-("&! !"""&!)&"$("('"'' ;66 "!!"7:6 " $&(+"!)!"''8;66 $!(!1 !(! !(" '("' ("' ' ')" '( $"& 76 '' '! !!*! " ! " '!"' (",1 " !()&. ')' !' "' !(#! '("' ' &' #! %) $!(!0 ' &."! $!'& %) (! ("' ' !"!' ' 0 )!%) ') $& & "!(" $& $&& )!' +!(' 8< )*( $ $( %+ $: ( -" "3 ) $!$ )+ "%" " $*($) *()*$("$) $!$ $) *()*$("$) ")"( 0/$))$ )4 +"'+*$- *" $)()+ *$))*+$))3 )"((&()"*&$( )+ !/$( &$*" / *$ ( 3 )$ )+) *$) !$+ $() ") / &$*" )* 0%" )+#$ 6!$)*( " &($ $"%" )+#$ "$5 " ($$()7)+(&()*!$ + +" +(!&$(*"*" ()" *(&+*$$"*( $ $("+($&*$/)+)*+ )$5!$( )4 $!$()+!"&")!$)'+("&(* $)"+-$)"$!&($)+ ("* +"$ $ -($) $) (!$) )$) 6(!0&"3 "*$" / - &($$74 " !($3 "$ / )*+$) &+ $) '+ $!&(" $) "+-$) "*& &*$) "*( )4 )&$"!$)-($)!*5" ))'+$(""$(!%"- $)+"'+"$"*-3/ '+ $!&(" )*+$) )$( / *$) -()$) (!$ $" )#$)3 (*()*) / +(%" !+/ *($"$)4 ," *$$ )*$3 +"$) (!$) )$" &("*!"*!))&($)"("))"*-)$" ()*$4 "*$"-+ )-"*)" $ $(&(*"$3&$(+" $3)(+" *("*-&( $"*($ $ $(" $)&"*)/3&$($*($3$((+")(*()*)(!$"*)/ ") !) -"*$))4 " "( )$" (!$) $" +" $)&$" / $" +" "* " 3-*" !*$ )!$&*$/ +"%"&($*")& )!*)$" $'+"$ ")*"!$"*$(0%""- )& )!*$)/)$"!"!) )"*($")"*()/$" $*($)!!"*$)4 + )"$ +" )"*+( &""* )(($ ( (!$) +/ &$)$ $ ) %!$3/'+)% $)**+ "(&$$))) &"*"/-*("3)"$ ) $)) )& !"* "* " $) )$) *"3 !$*("/ *$&(!*$ / $!)(&&( -*(*!/$.(0&"4 +"'+ $)"+-$)"*$! )&(($"$!$+" *("*-&( $"*($ $ $( "+($&*$ +"$) $) " !$)*($ +" )&*($ !) !& $3 6 !$*(" / *$&(!*$7 / " !$"$*(& ()) &( ) 6&"*"3 !$*("3 $.(0&" / *$&(!*$74 $$)*"*3)* !$!"*$"",")*+$$"*($ $!$)*($ (!"* '+)+"%""!$"$*(&))+&($( !& $"*$! ) )$)4 $(*$$ $)!&()"-+ 0( *(*!"*$ ! ")*$), *!$)#$)*!")&$)*+ $ &( *(*!"*$ ("*))"($!)'++()"$"$ $($!$)"*$!&($!""*4 *$." )$( $ $( " )&)* / ) )*$")3 " )& " )*$" (- 3 )$($"$/( $"$" !$( &(*-!+)+ (4&$) " *(*!"*$ )"($!!$) 3 !(#/ *")$" )+(" +" *$ "*"$&*-$ *$." )" ( %" $" ( %" !+)+ (4 &)( $) -0 !) "+!($)$) )*+$) '+3 ) !&$ "-)*%" )3 &$(*" *$) " -$( .)*" !")!$) "*"$&*-$) "&""*) 9: %&$ $ !' < &$!'%'$."!"$&$&& %%$ % $ % % %'% & &/ & * &'34$"$%&& * !%" && %& &'/ %'$!'$ &!* %%&&'"$ & '"% '$ "$ *& 7:6/666 & %/ & * % "$ ' " $ %&$' &''. ' &$ $! $ " %&)/ *%& ; %$ &" % ' !& %&& % %&$' &''."$ %! %&" %+%'&,"$&/ % +& )&$ '%'$ + &( % $ " & $ + % $ % $%$) %% $%%%&$) % '&! / '& )%& % & & * % $ $ % % % % '$% #' "$ ) & * % $ '! % $% "&)% ' $ $&. $ &) '%'$*%) %' &. '$$&. $&)% %%$% "&)%/ & * % %&$ , "$ &$&& % &$&'$%. % %"% %+ %! %%&! %'%'$%/% &$&'$%.%'"'& )%& '$ % ! .% &) % % %& %&+ %'% &) &$ ' '%'$/ % %"% % % &$ % ) '&$% + % %&% ' (%' ' $'" '%'$ "$% &) &$. + % ! % %&! % % &$ % '%'$% ) '&$% + % %&% 3'#' &%%" $ % )& %) '&$ %4$'" %'%'$% %&%+& %&% #''% )& %& $%!+" %&'$% $%' )$%$ %'$" / % %"% % '%'$% "' %$ $ %. %' ' %! ' %&$'&'$'%' %#'&). %'$ %% %%%&$) % &$ "$$ . + % %& % % %'$% ' %! ' &$! ' & ' %&$'&'$ %%& $) %6</ %& % &$%& $ % '%'$% $%" &$&& $&$%%! $% & '$ % )" & $+$'!% & '$ %+#'%'+"'& $&%$%% $$ $ &$!/ % $ % % %"% % $ %. "$ ) % " $ ' %! ' %&$'&'$ '%' %#'& ). %% $ % $&/ %! '%' %#'& $ % (%' "' &$$ #'$ &) $2 $ % & '$ % / + . + % &$'$ % % (%' % ) %/ %& %#'$ % $% $) %% "' "$ ) $ ' %"% %& % (%' % + %$% #' $'%'$*""$)&/" $& $ $ %%"% %$ %$% #'"% $%"% $ &(% $'%"$$&$!'%'$/%& %% %.&$"'& $&$&$%!#''%"% / % ! %$ $ % & & '% $&$%&% "$ "%/ & % $ % "'& % & %$ % % % ' % % "& ! '&&)& $&/ & $ "& %$ %%"& %.&/%% $! "'& % & $. , % &$ % $'" % '%'$% ' "&$! $$$ &" "$(%'67:/(%&"!&%%. $! %0"'& % & %%1 3+ % &$$ " &%2$ %4 % $%'& ' %! '%'$ " $ % $$ 3'% *%) . &$'. " %&'$ $!4 #' % % $% '%'$% + "$ ) ' %$ *%) '! '$ '%'$/ $! %" $,!"$ %$"& $%" %&%"& % " & $.#'"$ ) '$!+$"&!' %>8% $&' %$ "% &$& "%& /&. &$!)>82 9= $%## &7 %#&#!#($ *$!%$#$%*$."&& &$& $#$&$&#$*# %#%&#$&$&#$$0 $"& $&# %#%&# &$&# * %# % $ $# #$ !#( & % ). # # * %#$ $&$%$ "& $$+ $ !%#$0 $% ! %$$ $ #%. * #%$#$#$$&%#%%&$#.*"& # & &#&$&#"&.$($%.$!##$ $%#$"&#$#$0 &#%.$.% $&*$"&*%# $$%$$# #$0 $%$#($&%($#%# &$&# $# # %. (#$ $#($ $ $## & #& # %$ "& ## &$&#0 # (## $#( $ #+ (#$ $%&$ "& !# #### * !#%$&##&! %$$$#$$$#%$"&)!!$% %!%(#%40 $$+ !## * %# !#& !# % # $ $ !# !$ % %#!&% %) $# $#$ #$$ "&.!#!.%#( $!#%(&$&#.#0 $!$&$&#!&&####$&%%$ &$&## #%#%$. !#%#&$ & $ (#%# !#$$ !#$ & #( %$%$$ $$0 $ #%$ &$&#$ !& $# '%$ $% $%& 0 * !$$%$%$!$%$&*$0&"&$$#!#$ &%%.!##$"&%$%$$%$0 $ &$ )% #+!. %#%% $ &#$0 (%#$ $&!#$ #&$ . !&$% "& !& !#(# &$%!#$*&%#%.'#*#($$!$$0 $ #%$ &$&#$ #$!#. %#. +!# * ## $ &$ %&0 #& !#$ %( &#. % %$ $ #$ &$&#$. * & $ (0 $%$ $ $ !# !#$%!#%* %#!&%$0 )%#% %% !& &$#$ !# %###$%# $ %$ $%$ $ !$0 &$ $!$%$ # $ &%# '%$ # #$ # & * $ %(. * $ !%%0 & &% $& $%#(#%0 % !& $%##$ 3. 6 $ )%#% # $!&$ $*&*&#%(#$$.!#%###$%#$%$$&#$$ !$/$ .!%$ *&$$0 $#( "&)%#%!$& % $ %( !# # !$%!#%# #. * %###$%$ *!#$ #$!#%#!#&$!#$%0 52 &'%!!% "(!@ ''!0:9#!%*!%0('!&'!&&!&!&!#!&, '* #'0 &(,! &!!2 &'& !&& ! '% & !%& &( !'!+2 " ! '&! ! #%'! #% ('% & &'(!& !! !& '(%'!& ('%!& #!&#%'!0 !!% #&!'!0 !!% ' , & &2 (! ! '&! ! #%'! & &'%%! &0&!&&'(*%!$(&%(<9C,!%&#%#%!(%&!%!*!2 & & &(%! % >=9 !&& % ! '&! ! #%'!$(&'%"%#'!&&,!%&&2 !&&-!'%:994;992'-:@9 '% ('!' !' :@: 1 #%#%!0 :;= 0 &''!0?=,'(%'0@92 '&!'!+'&#(&%(!#'!-!'%&!& &&2%'!'!%$(%&('!&!'&!%%!&5;3 !!'!:99C6&!#%!'!#!%(!&:9!%590:?362 !&'!&&%*'&#%#'!!!%&!&(&'!&'%$(-'&0 &',3!&!2 !&&&'%(&!("!!=C:9C !'! #% *% !!% * !%!2 !! #!% * !%0 #( '% &%& '!& &!& (& #%&!&2 #'& &!!& !! #( !%& ! &(% ! !#!& , ! !#!&2 *%' #' &!% #!& ( '! &' '*! (! & &'% ! !#!& , &!% #!&$(('!&'%&'!%!&!%%'"&'%!'&'2 %!+!%'(*#&'$(&-!'! !&'%&!#%!%!%!(!&&(&"! !!%2 & (&& , !& *"'!& &! %('& !& #'& %!&!& #!% #%!# %0 ! #!% !& '%''! ('-!& 5$(!'%#"%!&62& #!% ! ''! #!%'' !!'! +'! '!! &'!& &'!&2 &! &'%" !#!& & (&& , !& *"'!& &! %('& #%% &'(%%&'%''!2 ('%'%&!*!#%!=4:93>4@!%&*!%2 #(&%)''%''!!90=4;!#%!2&(#(&'!$(! %&#!!&'%''!&'%!%&&'%!!&'%"!&&<4@3@ *!%!'%*!&#%(&"'2 <: /0.&*&*. +1&*O *0.*/.'*/-1/.("0*/(*0.*/*1&*/,*.1("(""+(*(.0 54,""5-1(*!(/"*"(&1"*//,&(.&,."&.'*&* "*(&'*'(0* /."0*/B • • • • • • • • • • • • • • • • • • • • • •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