PERSONAL INFORMATION Name: Nationality: License Number: María Otaola Argentine. 111494 UNIVERSITARY DEGREES 1997 - 2002 2010-2011 University Attended: Medical Degree (M.D) Universidad de Buenos Aires, Facultad de Medicina Medical Diploma Interstitial Lung Disease Fellowship Buenos Aires British Hospital Interstitial Lung Disease division 2007-2010 Pulmonary Residency Hospital de Clínicas in Buenos Aires. Respiratory Medicine 2003 - 2007 Residency Cemic University Hospital Internal Medicine. CURRENT POSITION Since 2013 Principal Investigator in the Clinical Research Department Pneumology area Centro de Investigaciones Metabólicas (CINME), Buenos Aires, Argentina. 2012 Medical Doctor in the Clinical Research Department Sub- Investigator, Pneumology area Centro de Investigaciones Metabólicas (CINME), Buenos Aires, Argentina. Since 2010- Pulmonary Staff in CEMIC University Hospital Ppulmonary clinics, Pulmonary laboratory, bronchoscopy 1 FORMER POSITION 2007-2010 Higher education on Respiratory Medicine Hospital de Clínicas Medicine School Buenos Aires University 2009-2010 Higher education on Bronchoscopy Argentine Association of Bronchoesophagology (AABE) EDUCATION Clinical Research 2010- GCP for Investigational Site Staff Course, 2010. Pfizer CLINICAL TRIALS: EXPERIENCE. In the Past 2010-2011 B1321001 : A Phase 3, Multi-Center, Open Label Study To Evaluate The Long-Term Safety Of Monotherapy Sitaxsentan Sodium And Combination Therapy With Sitaxsentan Sodium And Sildenafil Citrate In Subjects With Pulmonary Arterial 2012 HZC115247:A 12-week study to evaluate the effect of fluticasone furoate (FF, GW685698)/vilanterol (VI, GW642444) 100/25 mcg Inhalation Powder delivered once daily via a Novel Dry Powder Inhaler (NDPI) on arterial stiffness compared with Tiotropium bromide 18 mcg delivered once daily via a HandiHaler in subjects with Chronic Obstructive Pulmonary Disease (COPD). 2012-2013: CQAB149B2401: A randomized, double-blind, parallel-group, 26-week study comparing the efficacy and safety of indacaterol (Onbrez® Breezhaler® 150 μg o.d.) with salmeterol/fluticasone propionate (Seretide® Accuhaler® 50 μg/500 μg b.i.d.) in patients with moderate chronic obstructive pulmonary disease INTERNATIONAL PRESENTATIONS 2010 “COPD in Buenos Aires: comunity screening during COPD global day” Gene R, Apelbaum G, Boyeras I, Lonegro G, Aguirre R, Giovini V, Otaola M, Rolando L European Respiratory Society Annual Meeting, Barcelona 2 2011 “Rutine Endotracheal Aspirate (EA) as strategy for antibiotic prescription in ventilator associated pneumonia (VAP)” Rolando L, Aguirre R, Giovini V, Otaola M, Baillieau, N, Sarquis S., Sosa, A., Luna CM. American Thoracic Society Annual Meeting. New Orleans. 2009 “Effect of antimicrobial therapy (AMT) on endotracheal aspirate (ETA) bacterial eradication and on the development of antimicrobial resistance, ventilator-associated pneumonia (VAP) and mortality due to VAP.” Otaola M, Baillieau, N, Sarquis S., Sosa, A., Luna CM. American Thoracic Society Annual Meeting. San Diego 2007 “Increase in endotracheal tube (ETT) resistance after its use in ICU patients under mechanical ventilation (MV): Forced oscillatory technique (FOT) evaluation.” Otaola M., Casaglia D., Chiapella M., Rios F., Guardia S., Fernández A., Apezteguia C., Sala. European Respiratory Society Annual Meeting, Stocolm NATIONAL PRESENTATIONS 2010 “Four year survival in patients with usual interstitial pneumonia (UIP) secondary to idiopathic pulmonary fibrosis (IPF) and connective tissue diseases” M Otaola, S Quadrelli, G Tabaj, L Molinari, V Di Boscio 38th Argentine Association of Respiratory Medicine (AAMR) Conference, Mar del Plata 2010 “Bronchoscopic diagnostic yield for infections in non –HIV inmunocompromised patients in an University Hospital in Buenos Aires city in the period 2000-2009” VIII Southamerican Conference and XXVII Bronchology Argentinian Conference in Buenos Aires, Argentina Respiratory Endoschopy Southamerican Association (ASER) y Argentine Association of Bronchoesophagology (AABE) 2009 “Pulmonary function tests and 5 year survival in a systemic sclerosis cohort” 37th Argentine Association of Respiratory Medicine (AAMR) Conference, Mar del Plata 2009 “Pulmonary involvment prevalence in a systemic sclerosis cohort” 37th Argentine Association of Respiratory Medicine (AAMR) Conference, Mar del Plata 3 2009 “VEF1/VEF6 fix cut off values for obstruction diagnosis for the diferet reference equations.” 37th Argentine Association of Respiratory Medicine (AAMR) Conference, Mar del Plata 2008 “Impact of preventive treatment with antibiotics on the levels of multiresistance in ventilatory associated pneumonia. “ 2008 2008 “Early colonization of patients in mechanically assisted ventilation and the influence of antibiotic preventive treatment”. 36th Argentine Association of Respiratory Medicine (AAMR) Conference, Mar del Plata “Bronchoscopic diagnostic yield for infections in non –HIV inmunocompromised patients.” 36th Argentine Association of Respiratory Medicine (AAMR) Conference, Mar del Plata 4