Santiago Ramon y Cajal and Barcelona: a failed encounter Prof. Isidro Ferrer, Institut Neuropatologia, Servei Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, CIBERNED, Hospitalet de LLobregat; Spain If you want to succeed in very arduous tasks give them all your will, preparing longer and with greater effort than appears to be necessary Santiago Ramón y Cajal. Mi infancia y juventud The history of my achievements is very simple: it is the common history of an indomitable will power focused on succeeding in life at any price Santiago Ramón y Cajal. Historia de mi labor científica L’eixample, I. Cerdá, 1859 The Cathedral of the craftsmen Barcelona’s Cathedral “Catedral de la Santa Cruz y Santa Eulalia” was build up during the XIII and XV centuries but was not finished until the end of the XIX century in a neo gothic style. Views of the Cathedral by 1980 and 1990 The Cloister, XIV-XV Centuries Josep LLimona, 1920. Christ burial Santa Maria del Mar, the Cathedral of the fishermen Biographical sketch 1852: Born in Petilla de Aragón (Navarra) 1873: Military Doctor assigned to Cuba 1875: Associate Professor of Anatomy at the School of Medicine in Zaragoza 1879: Director of the Museums at the same School 1883: Chair of General Anatomy at the University of Valencia 1887: Chair of Histology and Pathological Anatomy of the School of Medicine at the University of Barcelona 1892: Chair of Histology, Histochemistry and Pathologic Anatomy of the School of Medicine at the University of Madrid 1906: Nobel Prize 1920: Foundation of the Cajal Institute 1934: Died in Madrid Petilla de Aragón. Photographs made by S. Ramón y Cajal De Carlos Segovia JA, Los Ramón y Cajal: una familia aragonesa, Gobierno de Aragón, 1999 Silveria Fañanás García Wife of S. Ramón y Cajal from July 19, 1879 until her death in 1930. They had seven children The only relative who attended the weeding was Cajal’s brother Pedro. Antonia Cajal with Jorja, Pabla, Santiago and Pedro, 1890 Pedralbes monastery Patchs and orchads Casa Batllo Harbour, 1880 Palau Reial Major Palau de la Generalitat Plaça Reial; Royal Square Liceu Theatre Santiago Ramón y Cajal obtained a Chair as Professor of Histology and Pathologic Anatomy in the School of Medicine of the University of Barcelona in 1887, and he worked in Barcelona until 1891. This was a fascinating historical period as Barcelona was in the blossom of a renaissance of social and cultural identity. On the one hand, the bourgeoisie promoted a cultural Catalan movement based on architecture, sculpture, painting, literature, poetry and music, together with innovation in industry. On the other, social movements organized trade unionism. The authorities were devoted to the Universal Exposition of 1888 and engaged in later development of the city beyond its historical limits. F. Rius i Taulet, Mayor of Barcelona, 1872-1873; Jan 1874-Dec 1874; 1881-1884; 1885-1889 1888 Universal Exposition in Barcelona Opening of the Monument to Cristopher Columbus Internacional Grand Hotel Launching of the newspaper Noticiero Universal First Congress of the Spanish Socialist Party (PSOE) and the trade union General Union of Workers (UGT) Jocs Florals: Catalan Festival of Poetry and Culture. Closing speech by Marcelino Menendez y Pelayo supporting the development of the Catalan language and culture Poetry by Angel Guimera Mar i Cel Pàtria: Catalan patriotic poem by Jacint Verdaguer Monument to Rafael de Casanova, defeated leader supporting independence for Catalonia 1891 Foundation of the Catalan Union, Right-wing Catalan nationalist party Foundation of the Orfeo Catala, Official Catalan choral society Paintings by R. Casas and S. Rusiñol Monument to Cristopher Columbus Triumphal arch Café Restaurante del Parque The cascade and the fountain, Ciutadella’s Park, 1881 Parque de la Ciudadela Catalan nationalist meeting, Teatro Novedades, 1886 After the ball, Rovira Ribera 1887 Priest J. Verdaguer by R. Casas Santiago Rusiñol i Prats Pawnbrocker’s, 1889 Ramon Casas, portrait, 1889 Ramón Casas Els quatre gats Ramón Casas. Death penalty, “garrote vil” Ramón Casas. Baton charge, 1899-1900 (dated 1903) Ramon Casas. Fresh air, 1892 Ramón Casas. Ladies portrait, 1896 Pablo Ruiz Picasso. Portrait of the Artist's Mother. 1896. Pastel on Paper. Self-Portrait. 1896. Oil on canvas. Museo Picasso, Barcelona, Spain. Pablo Ruiz Picasso. Science and Charity. 1897. Oil on canvas. Museo Picasso, Barcelona, Spain Official diploma of the Universal Exposition of Barcelona to Santiago Ramon y Cajal for his participation with histological preparations of the nervous tissue The Universal Exposition of 1888 remained open for thirty-five weeks. A million an a half people visited it, at an average rate of about six thousand a day. Most of them were Spaniards; the show attracted a healthy influx of foreign visitors, but the predicted flood of them did not come. When its doors closed on December 9, 1888, the books showed a deficit of six million pesetas, which surprised nobody. Rius i Taulet, it seemed, had a simple stratagem when money looked tight: he asked Madrid for money, got none, and spent it away. So it took the city another ten years to pay the debt... Robert Hughes. Barcelona, 1992 The Universal Exposition in Barcelona in 1988 turned out to be a great event, because of the visibility of the technical, industrial and commercial success of Catalonia during the time of the Restauracio. This accelerated the international impact of Barcelona, and permitted, under the direction of the Mayor Francesc Rius i Taulet, the culmination of town-planning reforms geared to activating the economy and labour. Cronologia d’Historia del món. Edicions 62. Director: Jesús Mestre i Campi 1888 Award for the presentation at the Universal Exposition Several publications in la Gaceta Médica Catalana Creation and launching of the “Revista Trimestral de Histología Normal y Patológica” Publication of studies on the structure of the cerebellum and retina 1889 “Manual de Histología Normal y Técnica Micrográfica” Publications on the structure of the spinal cord Older son suffers serious typhoid fever Daughter Enriqueta dies in June as a result of tuberculous meningitis Meeting of the German Society of Anatomy in Berlin in October: International success of Santiago Ramón y Cajal Theory of the Functional Unity of the Neuron 1894 Chick cerebellum 1890, 1891 Publication of the book “Manual de Anatomía Patológica” Publication of numerous papers about the structure of the nervous system Several studies of the development of the nervous system: neurogenesis, discovery of the growth cones Theory of the tropism of the neuron: axonal growth, arrival and targeting Ontogenic study of the cerebellum Studies of the structure of the cerebral cortex Studies of the neuroglia Structure of the olfactory pathways 1892 Several studies translated and published in “Archiv für Anatomie und Physiologie and in the Bulletin Médicale de Paris” Faculty of Medicine of Barcelona Plaza de Cataluña: Catalunya Square Paseo de Gracia, 1888: De Gracia Avenue Central Catalana de Electricidad, Pere Falqués, 1897 Palau Guell, A. Gaudi, 1885-1890 S. Ramón y Cajal: An Spanish patriot We must work for the prestige of our race, showing foreigners that those who centuries ago immortalised their names with geographical discoveries and who illuminated peaceful revolutions in the fields of art, literature and history, will meet with equal enthusiasm the study of nature, collaborating with more advanced people in the most commendable acts of civilisation and progress. Cultural flourishing is the result of the contact between separate cultures and civilisations. Dr. Jaume Ferrán Dr. Bartomeu Robert Mayor of Barcelona, 1899 Political interests were not directed to the study of Neuroscience but, rather, other aspects as the study of infectious diseases, epidemiology and vaccination deserved priority. In spite of the success of the work of Ramon y Cajal, particularly in Germany and France, his discoveries were almost ignored or minimized by the academic and political authorities in Barcelona. Before he decided to apply for a chair at the University of Madrid, which he was obliged to do for economic reasons, we had negotiated with the municipal authorities of Barcelona regarding the possibility of creating a laboratory of histology under the direction of Dr. Ramón y Cajal. But the municipal authorities, who devoted most of their efforts to external, useless events, did not listen to our request, which was made without the stamp of a lobby or the help of a politician. Cajal left our city in yearning, and we remain ashamed. Josep María Roca. Tribute to the teacher. Barcelona, 1923 “Really grieved, I had to abandon my friends and, with them, a city where I found an ambience particularly favourable to carrying out my scientific studies and publications. With no less sorrow, I said goodbye to the Pajarera were I spent unforgettable moments.” Prof. Diego Ferrer. Cajal y Barcelona 1890 1899 Publication of “Textura del Sistema Nervioso del Hombre y de los Vertebrados” 1902: Jorge Francisco Tello (1880-1958) 1912: Nicolás Achúcarro (1880-1918) Director of the Laboratory of Histopathology 1913-1914: Publication of “Estudios sobre la degeneración y regeneración del sistema nervioso” 1915: Pío del Rio Hortega (1882-1945, Buenos Aires) began to work with N. Achúcarro 1920: Rafael Lorente de Nó (1902-1990) 1930: Silveria Fañanas, Ramon y Cajal’s wife, dies 1932: Publication of “Técnica micrográfica del sistema nervioso” (with de Castro). Inauguration of the Cajal Institute 1933: Publication of “¿Neuronismo o reticularismo?” 1934: Santiago Ramón y Cajal dies From left to right: Gonzalo Rodríguez Lafora, Domingo Sánchez, Jose María Sacristán, Manuel Gayarre, Nicolás Achúcarro, Santiago Ramón y Cajal, Luis Rodríguez Illera, Juan de Dios Sacristán, the technician and the caretaker. Published by “La Esfera”, 1915 1920 Fernando de Castro Last scientific publication of S. Ramón y Cajal. First appeared in 1933 * Consell de Cent, 304, 2n In the face of the old teachers, young scientists must not keep quiet in amazement, but rather alert and zealous. The specialist works as a larva placed for life on the same leaf, with the hope that his small work may swing isolated in space. The general scientist foresees the common trunk of the several branches that form the tree. Spain will not leave its mental dejection until the old heads of the professors, oriented to the past, are replaced by new minds oriented to the future and progress. Reglas y Consejos sobre la Investigación Científica. Santiago Ramón y Cajal Cajal was a complex person with lightness and shadows, able to offer the highest generosity while also falling into inappropriate wickedness. He was demanding with everyone, especially with himself; tireless; arbitrary; ingenuous; audacious; arrogant; clever; persevering; skilled; and above all, driven by a strong will-power, inexhaustible self-confidence, and an astonishing capacity for work. He was not a superman. But he was a wise person who learnt to see what others did not see, who learnt to understand and to perceive the things around him, who learnt to interpret what he saw and to take advantage of current methods and advances. He was the discoverer and the first fair chronicler of the brain. Antonio Calvo Rey. Cajal. Triunfar a toda costa, 1999 (Triumph at any price) Ramón y Cajal produced in Barcelona the most important discoveries related with the nervous system, including the theory of the neuron, the theory of neuronal polarity and the theory of the neuronal tropism, in addition to crucial work centred on the development and structure of the nervous system. His work was presented in Berlin in 1889 and immediately recognized and respected internationally. Yet in Barcelona his work was practically ignored. He was forced to promote and finance his own publications, and his studies, most of them carried out at home, did not receive the support of the university authorities. This was not the consequence of a confrontation but rather the result of an insane neglect of science.