CNIO Meeting BLADDER CANCER

Centro Nacional de Investigaciones Oncológicas (CNIO)
(Spanish National Cancer Research Centre)
CNIO Meeting
BLADDER CANCER:
Searching targets and biomarkers using genomic and proteomic
approaches
Madrid, October 5-6, 2006
Abstract submission deadline: September 1, 2006
Organisers:
Marta Sánchez-Carbayo
Molecular Pathology Program, CNIO
Carlos Cordón-Cardo
Memorial Sloan-Kettering Cancer Center, New York, US
Scope:
Bladder cancer is a genetic disease, driven by the multistep accumulation of genetic and epigenetic factors,
among others. These molecular alterations result in uncontrolled cellular proliferation, cell cycle
deregulation, decrease in cell death or apoptosis, blockage of differentiation, invasion, and metastatic
spread. The particular genetic and protein expression alterations that occur as part of the crosstalk
between these pathways, will in great part determine the biological behavior of the tumor including its
ability to grow, recur, progress and metastasize. The advent of high-throughput methods of molecular
analysis can comprehensively survey genetic and protein profiles characteristic of distinct tumor types
contributing to a better understanding of the molecular events taking place in bladder cancer progression.
The Bladder cancer: Searching biomarkers and targets using genomic and proteomic approaches Meeting,
aims for the discussion on the clinical impact of targets and pathways identified to be altered along
tumorigenesis and bladder cancer progression using genomic and proteomic approaches. Such targets may
underlie a particular clinical behavior and be developed into novel and specific tumor markers. Moreover,
they may lead to the development of targeted therapies, that potentially be tailored to the aggressiveness
of bladder tumors.
Format:
Speakers: 30 minutes presentations, 10 minutes discussion
Oral session selected among applicants abstracts: 10 minutes presentations, 5 minutes discussion
Poster session: exhibition through the whole meeting
Abstracts submission deadline: September 1st, 2006
Registration fee: 150 euros
Centro Nacional de Investigaciones Oncológicas (CNIO)
Melchor Fernández Almagro 3, 28029 Madrid, Spain
www.cnio.es/meetings
meetings@cnio.es
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Programme:
October, Thursday 5th
9:15 - 9:30. Welcome. M.A Piris - Director, Molecular Pathology Program, CNIO, Madrid, Spain
9: 30 - 11:45. Session 1 / Topics: Bladder cancer: Clinical needs/ Epidemiology/ Epigenetics
Chair: Asociación Española de Urología
Invited Speakers & Selected oral presentation
A. Alcaraz - Hospital Clinic, Barcelona, Spain
What do Urologist need from Bladder Cancer Research?
N. Malats - IMIM, Barcelona, Spain
Environmental risk factors and genetic susceptibility of bladder cancer: the complexity of a complex
disease
M. Esteller - CNIO, Madrid, Spain
Epigenetics in Bladder Cancer
11:45-12:00. Coffee Break
12:00 - 14:15. Session II / Topics: Molecular Pathology: preneoplastic (clonality)/ superficial (FGFR3)/
invasive (genetics)
Chair: Sociedad Española de Anatomía Patológica
Invited Speakers & Selected oral presentation
A. Hartmann - University of Regensburg, Germany
Genetic alterations in preneoplastic lesions and noninvasive urothelial carcinomas: oligoclonality of bladder
cancer
F. Radvanyi - Institute Curie, Paris, France
FGFR3 in oncogenesis, from men to mice and back
M. Knowles - University of Leeds, UK
Genomic alterations in advanced bladder cancer
14:00-15:30. Lunch
15:30 - 17:45. Session III / Topics: Genomics using tissue specimens: Superficial/ Invasive/ Metastatic
Chair: Grupo Español para el Estudio del Cáncer Urológico (SOGUG)
Invited Speakers & Selected oral presentation
T. Ørntoft - Aarhus University Hospital, Denmark
Molecular classification of bladder tumors using genomic approaches including microarrays
C. Cordon-Cardo - MSKCC, New York, US
Rb, p53 and Pten pathways in bladder tumor progression
D. Theodorescu - University of Virginia, Charlottesville, US
RhoGDI2, a novel biomarker and target of urothelial cancer metastasis
Centro Nacional de Investigaciones Oncológicas (CNIO)
Melchor Fernández Almagro 3, 28029 Madrid, Spain
www.cnio.es/meetings
meetings@cnio.es
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October, Friday 6th
9: 30 - 11:45. Session IV / Topics: Clinical management: Tumor prognosticators/ BCG-TIG3/
Chemotherapy
Chair: Sociedad Española de Oncología Médica
Invited Speakers & Selected oral presentation
J. Palou - Fundació Puigvert, Barcelona, Spain
Clinical prognostic factors in T1G3: are they useful?
A. Lopez-Beltran - Hospital Universitario Reína Sofía, Córdoba, Spain
Survival Prognostic Factors in BCG-Treated T1G3 Bladder Cancer: The Role of Cell Cycle Modulators
J. Bellmunt - Hospital del Mar, Barcelona, Spain
Molecular predictors of chemotherapy response
11:45-12:00. Coffee Break
12:00 - 14:15. Session V / Topics: Laboratory management: International Consensus Panel on bladder
tumor markers/ Urinary Microsatellite/ Tumor pathways: cell cycle
Chair: Sociedad Española de Bioquímica Clínica
Guest Speakers
A. García-España - Hospital Joan XXIII, Tarragona, Spain
Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder
tumors: implications for tumor behavior
E. Zwarthoff – Josphine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
Early steps in bladder cancer oncogenesis
P. J. Goebell - University of Essen, Germany & Internacional Bladder Cancer Network
The International Bladder Cancer Network - Current Strategies in Marker Research
14:00-15:30. Lunch
15:30: - 17:45. Session VI / Topics: Proteomics using body fluids: 2D/ MALDI/Antibody arrays
Chair: Comisión de Marcadores Biológicos del Cáncer
Invited Speakers & Selected oral presentation
P. Gromov - Institute of Cancer Biology, Copenhagen, Denmark
Gel-based Proteomics in Bladder Cancer
A. Vlahou - Foundation for Biomedical Research of the Academy of Athens, Greece
Protein profiling of urine for the identification of bladder cancer biomarkers
M. Sánchez-Carbayo – CNIO, Madrid, Spain
Linking -omics in bladder cancer: from tissue to body fluids
Centro Nacional de Investigaciones Oncológicas (CNIO)
Melchor Fernández Almagro 3, 28029 Madrid, Spain
www.cnio.es/meetings
meetings@cnio.es
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