Optimización de métodos de criopreservación de embriones bovinos y ovinos Martínez, Alejandro Gustavo 2006 Tesis Doctoral Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires www.digital.bl.fcen.uba.ar Contacto: digital@bl.fcen.uba.ar Este documento forma parte de la colección de tesis doctorales de la Biblioteca Central Dr. Luis Federico Leloir. Su utilización debe ser acompañada por la cita bibliográfica con reconocimiento de la fuente. This document is part of the doctoral theses collection of the Central Library Dr. Luis Federico Leloir. It should be used accompanied by the corresponding citation acknowledging the source. Fuente / source: Biblioteca Digital de la Facultad de Ciencias Exactas y Naturales - Universidad de Buenos Aires ! " % % - & ' ( +( ) * , % +( ' ./ 0 1223 #$ * ) ( '' . (. ! ! "# ! ! "# ! ! 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" u 1;; , u < " ( < 2u " , / u u < u " , u " u u A1 = G (. ( M G . u < 7D7>, ( 3" < <: 3> 2u < "u " " " = <1 +* " " , u 1;; 19; L 2u 2u A ( $ ( u =DK ( ' >< " " u " u. u . " , % "u ( u 4 ' N " u u u = 2u " ' ' 3 " 5 :;; u :;; L . 7K < 2u " . u , " " u " u " . < u u " 8 5# " u < 1 " 7DDN / , " u < 771N < 7DBN ,< 7DD>, u " ' " = u 1>, u 1, % u O! 9O :O 5 , u 1O! D u @O " BO CO DO 1 ( u " 3" * "( $ %" # u " < u. u 5 % ( " " " u 5 = ( , & " < " u , u , " u , u . u u u ( u 4 u. . " u , u 9, % " = 65 u . ,< 779> " u & " , # u 9>, . " " u u " " u 5 >, " " " u' , 5 / u u u u u < 2u 2u 2u 2u " " = # < < " , " " u u" "u /u < " 5 - 9 / " . 5 " " " < " " " . ( 5 < " u " 5" , / " u " " < . 2u u "u 2u u u u " u " 2u " u " < . 2u * 4 < ! " * " + u " ( * #$( & 3 u = D@DO D7@> . P " ) " 5 ) u D7; 2u 3 < 2u = D::O 717>, < u # " " u " ( =) u u 5 ( " < D7 < D7C >, u u u . . ) 5 5 " 5 u u 2u < " 791 . u =P M G. u *u /u u u ( " 2u " ,< 79@N P u 6 3 < " P M G< 799< u u ' < . " M G. 5' .< 7@7>, " ' ' " u " # , 3" , " " ' " ( # , < u u , " u 3" " 5 " 2u ' " u /), " *# $ %" " , u " " ( " u " " 2u " " . u # " ' @ 5 u " 5 " u" ( < " 5 " , 6 ,& 3 " A - . # ) " P ! " M G. P M G. + G 791 , 799 & 799 ./ P 2u ! u )u , 7: .6 u u . 7C@ M 7CD "u 3 P 7: G " 4 7@1 . Q 1: . 0 5 + + D7; , 7:;< 2u * # < P " u " ( u =P . ,< 5 7: >, & u " < " < . M. u . " 2u 2u , < 5 2u 4 ' u" = < 1;;9>< " . u , : 3" C;< u" < 5 2u " u " " ( . < " 5 2u 5 " = < ( M < " I " " J= ' ' 5 ." u < u " 5 , * 5 " 5u " 3 , 8 ( u < " "u / 2u u " 2u u u 3 , =& . .+ u < " < " " u < 5 . ,< 7DCN & < 77;< 5 . ,< 7D7N < 7DB>, " " D; " u =& < 7DDN P =P ,< 7D:>, . " "u 4 < . u u "u 2u ( u "u " , 5 " 7C7>, % u 2u 2u " u " " u < . " " "u " . , ! " " " # " u 7D@>< u 7CB>, " 2u 5 " ' / u < " u 5u 7CB " M " , ,% " " "u " " ( =- u u ->, 5u " B u # 2u u , - -< " u " u# = " ( u R 3 S< " u " u < 1;;9>, & 5 ' 5 u . 4 77B .< u u u 5 Q < = >, " " # < " " u % u - ., < < 5 . " " 5 "u " " " " u " " ( " u " , " " , " A 5 / 5 u. " # " ( " u " " ( . & " < " , / 5 2u "u u " " < # # " # u u . 5 & " < u " , u u u # < uu <" , u u u 3 u u 4 , " " < 2u u ' " u u u 5 u . 2u u / P " < " A u " 5 5 u " " % 5 " " " u 5# " u u , " " u u . " " C u " 5 , % u # u " A u " # " " u u " " 5# " " 2u < u u 5 " ( , (" " & ' , 3 A 8 3 " " ( , ' " u " u. . 2u u" , 3 u " . " u " ( " 3 # / ( " ( u " u " " ' u " " " u u u , " < " ' u , u # "u . u 3 779< ) . +u < < < 1;< B D = B?> < ! < 2u < ' C 3 u u >< 1 = 5 . - = >. 3 . " . ( ' A < " < . 4 # 1;;;, & " 77C>, % >< 1 = "' . = u ! ( " =* >, / u u ( . * ( u 9D9 < + " * " " u ( u. " " . u , " u. " u " , " " ' u , 0u D u < 5 2u " u " < = 1;;;>< 2u u 2u ( " ' u u . 2u "u # ,< ( = 5 7DD> 2u " " " 5 M . * = ,6, ,> " u , u . ,< " " 7DB> . # A / u < u (u u " 5 " ,% 5 2u u u " 5 u " . , " "u =) " 4 8 < < u <" "u " u ." " u = . >, / ( u " . " u / , !( "$ %" # ! " ' u " . u 5 4 " . " u < u " " ' 2u " " u " 5 , < , u " # . u . ' < " ' < % < u " " " 7 < , < "u u 3 " " # , - #$$ %" & ! ( " u "&& u # " " u u # A/ u" u" u . ( , u " ' u u , u . u " . " . *u " " @:? " < u =* , & . ( 5 7D:>, "u " < ( " u " , u" 5 . u u 5 " < 2u , * " . " " , u " " 5 " 5 u u " u u " < < . ,< 1;;9>, / 3 " : < . " u " u u u 5u" < " u . /) ,< 1;;:>, "u " / = 5u" < u " @ u ( 9;? " ' u / " (. 3 " 2u u , 2u ' < 1;;;N < . , & u . 7DDN 65 " ( = )A/)< . ,< 77 N u " ) . /) 2u 5 5 " u 2u 1; " 2u # u u /) =Q ) . < 7D7>, "u " " ( . u , / = ; " #u " =% * +) u u ' u " . , % = 2u < 4 u B < "u u" =% u < 1;; >, ) < . " 2u < " < u " 2u 4 "u u > < 1;;9>, " u " u u 5 u "u , 3" u 2u " < " 5 N u " . u "u = ,< 7DD>, /u u u 5 ,< 77;N 5 A B 5u" < < # < 7D:N Q ( < u 1 " . u . 1@ 7D7>, & = u "u " . . " u , / u " , % 2u " " 8 . u "u = ' u " ' u u . u u < 1;; >, & ' " < u ' u < . B " & 4 . u ,< 77;N ( , / /) . u 5u" < 7D:N Q < 7D7N u "u < u u u u ( 1 u( . ,< 77C>, ( "u u 5 = 7D:N Q ( 5 < ( " u( 2u u u u ' " u < "u " u " . < 2u < 2u " < u" " " ' u " 2u :; . B;?, # ( 4 ( = u" < " 7D7N 65 u u " u u , 11 " 2u . *u " u < . 3 < 2u < 1;;9>, 2u 7DDN Q 5 3 . " C ,< 771>, < . 2u 4 ( 2u " 5 " < " " . u" 2u " ( = , u" " u" 5 " . u < 5 " < 77C>, " , ,< # =* u" u " "u / ' ( " , ' ' u u 2u . " # " u < 77B>, < " 2u 2u " 3" " u , u , & " 5u" < " < < . =* . " 771N ( " ( ( u u" 2u u" 2u " < < u ,< < 7D7>, ! u u . " # < :; . B;? = < 1;;;>, u " 3 5 ( . / ." " u " " " . " / = . #$$ %" " ! " ,< 77 N & " ./ < 1;;9>, "&( u " " u " # u " " u " 3" " . " < " u , " . . . ' - A/ " u u " u =Q # 5 . ,< 77 >, " " > " " u " A ( . > u < ( < . > u , / u " ( u " " " . " , / u "u ( 8 " " u 3 " " u " = ( < " =+ " < u < uu . u 7D;N / G . 5 . " " u u " . Hu G < < 779N % / 7C7N S u " " = < 771>, ( # = . u " uu Gu 3 77 >, 8 " u . "u 3 u . . u G< 7DB>, 19 ,< u . ,< 7D7>, / . 4 . 7D7N uGu . u 2u' / 5 )< /) . ( S u . & . ,< 7D7N Hu G . 2u = G " 3 ( u " ( G . ,< 7D7N < 77;>, ( 2u u u " u < . 2u " u " . , u u " 5 " ( 7DD>< =* . " ( 2u ) & ,< " " 779 N /u . ,< 7DCN & u u # " 5 . ,< u 5 " =)u u . ( < 7D7>, / u . M = ,< ( 5 . ,< 771>, " 7DB> < " ( u ( / u" =& . u " = uGu . " " ( ,< 7DD>, 3" ( ( u " u ' u / " " = . < D 2u <" # . 7D:N Ru . < ,< = u u . . /u< =. ,< 1;;9N S ,< u " u" " 77;N /u . . u 5 5 7DCN . 2u " . ,< 1;;@>, 1@ .T " u ,< 1;;1N / . # u 77D>, & " , < 7DCN>, + u +( u 7D7N * u u ( ,< B " u " # 3 < ,< 1;;9N 0 . ,< 1;;@N / u " u u. , u . u u " < . . ( < u uu < 7D7N uGu 7DCN & G . ,< . ,< " u =Q . " u u 5 . ,< 771N . + ) G < ,< u 7D7N ) . . u3 . u 779>, ,< uu u u " 2u' . ,< 77BN uGu . " 0 1 ! 2# " u $ ! ,< 77 N " !( " "&( < " . , # 2u " 2u "u " u u " < 1;;9N Q . ,< G < 1;;9N 77@N Pu 5 . " . ,< < 779N Pu 5 . u . Hu G < 77@>, & " ,< 77@>, 1: 5 . 1>, & < " " 1;? 779N * 77:N + =) ( u ,< " Gu =6 4 ( = u < " < u u u " " u " ./ 7D@N 2u 771N 2u' ) ,< . u u 2u ,< . 77;N 65 u 6 " u ,< 7D7>, "$ "&& ,< u u u . = . u " . " 0 uGu . u u. / u 5 77;N ( 2u < = u 7D7N 6 G 771>, / u " < < , & u u 2u . 5 . u < ,< 77 N 771N < < 1;;9N Q < 1;;9N / 6 1, " 2u u " " = + . < 7D7>, U6 " U! u " u U 5 G U 3" " u( . " U6 !1 . U & 2u 4 u !1 U 3" U* u " " U- " U u . %u u u . ( u u < < 2u " " 5 ' # 5 = u * .& u 5< 1;;1N ). 1;; >, . u. . u u 5 ( < 1;;@N 0 < " u u , " ' " u ' = < < 1;;;N u u ,< 7D7 < N Q ( " " u " . . " . " u u " , u " " D " " u u u 1B .u u u u. " 2u 4 < < D u < u 771>, / < < < u Q u < # u. u , < . u 2u u < " ' " u u u u " # 779N I #u 5 " J u =-M . ,< 771>, & u . G . . Q < ,< 77;N & = 77:> 2u 5 . " 2u . u , u . # u < u !1 . u 5 ' =" " u u " !1, u" u 5 < ' > < < u " < . ( =-M G . ,< . 771N Q # < 77 >, / ' u 1 C?< u" & " 2u < < " u " :;? = u < < 2u 5 " " " " & . u " u u " ,< 1;;:>, 2u' u ,< 1;;9>, 2u . . =+u u . . " , 8 < " " ' # " < , D 7D7N & u . = ,< . < 77 N u " u =) " ,< u 7DBN Q . ,< u u . 2u ,< u 777N Q5u " 3" . 77@>, <. u " " u , 1C < 1;;;>, / 2u " . . 0 ( # < u " 5 ( u =Q5u < u 771N + < 771N + 5 1 < " u " u < @ , % " u " , 3 ." u , / " , < u " u u " " ,/ u 3 ( u , u " " u " " u 2u 2u u . < " u . #u " , 2u u . " u =+ . ,< 77@>, ! " , / u 5u 1<9: =" " ' <9; T Gu < u " < " " '" 2u u ( " A" ' ( < u ,6 u . . " , u u" u " ( " , , 1D " ( " " =/ " u " <B 779>, / u & u >< u / u u u u < %u < 5 3 771>, % u " u u ,< < u . 9 . & # $ %" & ! " ( " 4 ( " " . ,/ " = 79 >< u u " u u" , 5 " . , " " u 5 5 , " u . u ) u . < " " 4 u ( u u < < u , u u " " A " u u " < u . u , u / . P 5 " 2u 4 ,< 2u 7DCN / ' A 3 u " " < . ( . < 5 u " < u 5< < 7D9>, / u < 17 2u 4 ( =) u . ( < " . P 2u 5 = 7D9> " ' , " " . . : =6 9>, 6 9, P u u ' =/ . 5 < 7D9>, $( 3 ($ (*$ " ! %" < u N 3 u' " 1 u u u " , % u , < N 3 u < . u , < ' ! , 9 + u " u " u u u. u 3 u' % % ' u . u . " N u 5 , u 2u " , - , " / ' 2u' 2u " . < . 3 , 3 u' , @ : N u u u " u u 3 u u ;K , < u " u ' u 3"u u u "u , 9; " 5 " ' " " . u '2u #u u u u u < . 2u 2u u u '2u " u " u < u u → " u / u " u =/u. < . u " u " ( " '2u u , "u u 2u # ;K , ' /u. u ' , 2u ' # I/ # < " # '2u < " u 5 , & u < 5 . u u ' ' " u u u " u u u 2u *u " u u → u u u ,/ u u u " . < % . * 5 < # u " 5 u / M 6 " u u , 6 J "u 7@;>< 2u /u. "u " " ' 7@; " " u " ' , "u " < * ' , & 2u " " & # =& . 5 = 5< ,< ( " 7@7> .< u " 4 u 7@7 " < u ( "' 4 " ( :;, 2u , u " & 4 5 . u 5 " 9 " u " 4 " 4 < . u ( . 2u u " u u 5 ' 7:;> , ' " "u ( ' . 2u 5 " <" < # & , "u " 2u " =P G " . ,< 1;; >< . " u " =65 5 . " " 2u & (u =/ " ' < # 2u u ( " " 5 5 ( 5 " u . # " " u 2u 5 " u ' " 5 ' u " " 5 6 . u " 2u 5 u u ( " u# ( 5 ' u . , " ( , / 5 " < . 2u u u , , =1;; > 2u " 3 u 5 4 " " # # " 5 " " 8 " . 5 ( " # < 4 4 < u 2u M . " " u = 7B@> . " < " u " u 5 =1;;;>, & @; " " 2u " 5 " " , / " ( (u = 7B:>< ' 5 ' " u 2u u 4 # " / ) u " < u u u 7:7>, , "u u u 4 " , " " " 5 "< . " 5" " u . 3" 4 3 G . " " ( " u " u " ,< 777>, " u / # u " u 91 " # u ' ' " " " u u ' " , , - "$ * u $ u " u " u 3" < " u < . , / u u < ' 5 , u , u 4 u " u " 5 " , < u u u " " 2u 2u u u u " < " " < 1;;@>, < " u . < " u = " < " # ! u # . 5 < u 4 , ! 2u " u. 3 " < " < " " u. . , " %u ' "( "( u 5 4 < . 2u ! u " " u 3 4 " ' 2u " "u u 5 u " , u "u 3 2u A / =V K T ( . >. " , 99 u < / u # u " u " , / " & " u . " u = " u 5M 7DD>, & " 5 . # < , / ' 3 u 5 7D;N . P5 < " < " 7CCN " u G M G . 7D@>, ,< # 7D;N / 5 u " . ,< u 7CDN / < 7D;N (u . 3 u " < . A / " / ( / ." u" " / ' T u u u , " 5 , u , u u u =X G M G . u ,< " 7D;N / < , 5 7D;>, / u 2u 3 I u J< u " 3" . 5. < 7D;N . P5 u < 7CC>, 9@ ,< , u " " , .T " u 5u 3" 5 / ( 1;;; " =X . 2u " 2u " , < 5 . u " . J> ;W , " ,< =I " u u = 5M & 2u 3 u u " u u u u 4 u. u . u ( " " u , & # u u u 5 u" " , # u ;K 5 u u u 5 u " 3 O@;K , " " < . , u u u < " " 5 , 5 #u " " 9: u " u. 5 u u , u ( 5 u u < u 2u " u " 2u 4 < , u u 5 5 u" " u u u u u 2u u 2u u 5 , " " u < . " # u u 4 5 " 5 2u u < . " u 2u "u u u u u 5 " u u " "u " u A "u " , . " u "u " " u " < u J>< ( " u =I % u u 3 " , u" ;K < 2u 5 u " " , <5 2u < ' , O " u u = u .% u u < 1;;;> ;K 1K @K BK DK 6 / 5 " u 2u u 7CC>, u u# u 2u . 3" 2u " # " u O7K ( " u 8 u u. 4 5 " 5 u 4 1>, u 2u u , / u 3" , / 3 5 " OCK < 2u < . 5 OCK u OC<:K > " # u" " < = : 3" u < ( " 5 u u 2u ' # = 5 u u u 5 " u =P5 " u "u u u 9B 5 u 1<:K T u , < . u , / ( " u 5 u u u u u u O :K u < " 5 ;K T 5 " 5 , < " u u " O :K , / u u u ( " u " . 5 u u <" 2u , ,1 " u = P5 5 u < 7CC> 7; D; C; =?> B; :; @; 9; 1; ; ; @K & . :K ' BK CK " " O: 7K ;K " " O CK >, u K 1K < u # DK u " u" u u ' u 9C 5 < " " # =" 2u " < u " 2u 4 " u I J # u "u u < u 5 O 7BK 5 =I J>, % u "u ( u u u u O: , OCK < u u u , /u I J< u 2u u " 5 u 3 u u 5 u " " < 3 u u u u , u u u 4 < u u u 2u '2u 5 " " u u < 2u "u , u "u u u #u < , < " < "u u 5 u " < " 5 < . u u '2u < " 2u 4 '2u u , 5 4 u u < , # , / " O9; . OD;K < . " u " . , / ' < " " < . " u u 2u u = 5M " < u 7D;N u < "u . P5 u ( " 2u 4 , < " " " 2u 4 9D u u 5 . " 2u 4 '2u u 3 2u , / 7CC>, " " . # < . 2u < 2u ( "u 4 u , , u 5 " 5 u u " ' " '2u u. u " < 4 , " " " " u < " u 2u 5 5 " u < u u 5 , " , " " u u P5 < 7CC>, / & !< 3 # < " 5 . " ' " " 5 < . u 4 " " . " " ' , u' u ;;, / 2u u < u u =Q " 5 < u u 5 < " u = u 97 " " " u u. < < < " " ,< 7D >, " 1 . 9K , " . u "u . 5u " # , / u u . "u " u < . u u u " = u " u " A < " . 2u " . " < ' 7D;N u" " ( < < "u u u. " 5M u > . 2u u . 2u >, " = " = 2u 2u "u , 5 " " % < " u " ( u < " 3 5.< u 7D7>, / u u , . . " ' & u u u. < u. " . " u " u 2u u " " # u ;K , u u , " < u " <: " u u < u u u u u u u u , u u u 2u " u 2u u " <:< " u" u 2u u 3 u u >, u u 4 " 2u u u u u , = = u 5 9 u ; u u 2u " > " >, u u " " u , u " u < . 3 " u "u u u u u " u . " <;< ;<:< ;<1: 2u u , u u / < u , " # u , " u u u u u " u , " =" " 3 " u , / " 4 / u " u < . , < " "u " " " " < " 2u < 5 " 8 u u u & 4 " " . ") . u , u 2u 5 u u u , " @; u u u " N 2u 5 5 " " u . " 6 " 2u " u " 2u u 5 =0 =I u < u 2u u < "J>< 7D@>, , % u u " "u "u " < " u " u 3" , & < " , " # = G ) ! C; " < "u ' 2u 4 " /u. = 79C> u " < # , . 4 ( " " ( < " ,& u " 7D: 2u . " < u . )u< 771>, ( 0 $ $ %" =+ u ( < " u u " , % u < 5" =/ " < 77 >, u " " " "u " " 3 5.< 7D:>, / "u u " ' " u u u u 5 , '2u u . "u 3 7DCN + u = . 5. . ,< 5.< 7D:>, @ 7D@N . u '2u 5.< 7D7N u" (u < 77;N + < / u • / ' u " " u , 2u u " , u • u u" . " " , 2u ( " . " u , " # < " u " 2u u u = / 5.< 7D7N Q # u " 3 u " 77;N + 8 5 5 5 , / u ' " # = 5.< u % !< 7D7N (u < =+ . " u < ;? " 5.< " ' " . B? D < u " < " u 3"u u # " " u u " # < 2u 3 7D:>, u " @;? = T >, / :<:? < " 5 . 4 < 7DC>, 1;<:? 3 ,< 7D >, . u u . . 2u u " . " u 5 u # u. < ' A u " u • u u 5 =Q < " u @K >, / 3 . 5 ,< 77;>, u . @1 =; u . " u ,/ u u " 5 5 u N u < . " u u # " % " u " " 3" u 3 , 8 3" < " " " $ u < u , ! " ' =* . ,< 7:BN & < 3 7C1N P u< 7B;>, + >5 ( u " " . " 5 . u u u. 3 " =P5 " u. '2u " u 7C1 " 7C1>, & = K T , # = < " ,< u OD;K > 2u " 2u / " ' . , u 5 11 " 4 " " 3 " " #u " & $ %" , u J 2u 5 * . 3" < I u * $ $ 3 u " u ,/ u. u < u " u " u < " ;K < u " u u 5 u , / " u < . 2u u " / u 2u u 3 5 u u < . !, / u " " , & u =+ " " " < 1;; >, 6 5 . 5u " 5 < . " @9 " " = . ,< 7DDN (u < 77;< P5 5 5 u " = ,< 7DBN + 77 N 6 G 5 6 / . 5 M . 5 . Q u . . ,< ,< M < < 77;N ,< 7DCN + 77 N ( 77;N 6 u uM . " " . ,< 7DDN / u 7DBN " < 7DCN + . 5 < . < ,< . ,< 7DBN ( . 7DCN 6 ,< 77;N P . Yu " 7D7N 5 (u 7DCN . ,< 7DDN " u " 77;>, 5 , u 3 < < < 7D7>, u . " 5 M . 5 " 3" 2u . 7DDN u " u < 7DDN 5 ,< " < < " . u " u 7CC>, u 5 u = < u 5 5< 7C7N P " "u u 5 ,< " 2u '2u < . u " . 5 " . " , #u " < 5 " , / u ' " # 7D7N , < 77 < P " u " " =/ ,< 1;;;>A " " 5 u u . , " " u u 3 u " , 1, / "u < " " 2u " "u ( " ' # u , " < u . u u @@ " < . 2u u 3" < " " u 9, / " , u u "u u 2u , "u < < "u " , 3 " " " u " ' @, / = M.* "u ( . 5 u < " 5 < 1;;;>, 2u " u , :, ( # " < ( " ( ' 3 3 " , 8 . 3 =* u " < ( u u( @: " ' < " ( < 77C>, 3 " , , 3 - u " " " . u u ,% " =P u " . + M " < 4 u 7C9>< 5 7C9 " 2u u " u 5 . " " u , / 5 < 2u " " " < " < " 2u . " u = " . ,< 1;;@>, / 3 "u # & A u # 3 2u 2u "u # " 5 " # 5 " # =* " . u ,< 779N ". " " =* < # 77B< " u # u 77:N # < 77C>, 5 ( , " 5 u " " " ,< . " ." " . " " ,< 77:>, " # , & . u , & . . u u , & , @B " 5 " A < u " " , ( . " , u 2u A! " . . , " " ( < 2u " . . & u u u ( " , @C , u < . u < / 4 / 4 / < 5 3" • < . u A/ +' A/ <* > . - / * u • )= • ) " " < u < u " <0 MH ! < %u < 0S< 8 , % " ) < u A = • A < < 3" >A * " " X &5 • =%& u u C • • " = . -%+>A - < , >A =" "5 )> . - </ " < !0< O u A 5 / < 5 <0 < 8 • * +) =+ • * " >/ ) . u " u 5 5 < u 5< 4 =& , *>A / . 3< u < • /) "u " u u u 5 & ( " < u " ,/ u < @D < u G " !< 8 , <0 MH , . u u = Q - ,< 5. ( u <& <8 u u "u u 0 &u >, /, /, - #* #$$ %" &# $ %" ! " " ! &" !( " " $ %" " "( " 4 N " " " u" u @ , u > %' @A 1<: " %' u ( " " C β u %' @ u " 4 " 4 " <1 15 "u , < <: 15 "u , < 15 "u , < ;<: 15 "u , 4 4 B< 1 1 >< , ,< . -%+ u 1<: * +) =+ D< %' D < , , ( ) . u A " %' u <7 u " %' BA <: %' CA A @ -%+, 2u %' :A 1 = u -%+> . : "u " u" < ' u" = u = -%+> %' ; 15 ) Z % A :C@ Z @; G >, / " = "&& C< D . 7 ( " = ' , " >< , , 4 u @7 . 9; " u , 15 $ $$ %" 1 & / 2u "u # $ %" ! 2u , " u 2u ,& " %& " < u ? u # . / ;? u , / . ? u =/ .P u "' u u u < u 2u "u u" %& ' ? ' 5< 7D@>, , u u . " 3" " u , ,9,@>, / u ' 3 =u u = 1; 9;> u 3" , /,, * #$$ %" $ %" 0 ! " $# ! &" !( " " "( " 4 N" " ( / " " u u u# C<: 5 " ;<;: T G A @ )( = . ;; 8-T " < . ;<:? < ;< , :; ' , G < 6 G. < X " > ,< 77: >, " < D ' u G :;; = " T = u u u ;<;: u D * 3 @: u " ) Z % A :C@ Z @; G >, / "u u " "&( 6 77 T " < # $ %" " & ( 8 ( 3 ' '2u " # u" < " 6 "u ) & : =- = " u > ;? =0-) ;; L = ! - > u /) >< L T = . u u # ,< 5u )< 77:>, / 1@ 5 97K u " :? !1< , ) $ %" " & ( /u u < :; L ! u u ( 3 ;BT & =& ; L T #(& ( 5. ,< B T u # " 5 " 5. 11 5 < u < " 7DB> ( < " , " 1; L < 5 " 6 /& u "u u 6 /& ; L < . u " " , = 7DB>, "&( u"u u = ! u N 6 . . ,< 7C1N < 1? = T > 1CB ! = ; 01< u 77 "u uu C? !1 . DD? 01< =1C@ 6 . :; L / " /) C[ " # & , & . "u ; L T L T ( ;? 77 u u < > . u T> . u " u < u >< 5u M . ,< ? = T > @D 5< :? @D 5< : ! u @; L # u 77C> . @ 97K , 5 T !1< C? !1 . DD? u " 77C> u u u u <: : = u ' u . , ,< u @D 5, / u ' u =/ . P 5< 3" u 7D@>, . . " 3" 3" %' 3 B.C= u . ; u 1; , / " ' > u 3" , /,/ #* #$$ %" &# $ %" ! " " &" !( " " $ %" " "( " u G >, / = # A @ @ u" # N " " u" " u u 4 u ( & B ' " =%' u ; " " # # < 5 # " ,< " & " # $ %" ! ) B 5 " 2u 5 1 ' , ' < . " u = ;<9 # >, / @D 5 "u 2u u" < 77:>, 15 u $$ %" 1 ' ( 2u " $ , B; u " 3 Z % A :B<@ Z : %' u " " 1:; 8- . u # u =0 u( B 1 5< " "&& . " ,< 771>, & ?< , , . u :1 < u ;<C 3 ( T 1?< , ,< . : >< , , <: u u %& u ? u 3"u . ( < 5 # G . ? =:; u u =9; u >, / u" u %& ;? . ? , / u " u =P " u 6 u u . " . ,< 7DC>, & 3" . , / u 3 ' =u u 1; . 9; > u 3" , /,5 * #$$ %" $ %" 0 ! " $# &" !( " " "( " u 3 = Z :<; G >, / # B 4 " u " < u N " u( " " " u u u Q*< 6u A @ u D * 3 1; " "&( " ' = u " Z % A :B<@ " u . ( =Q ,< u# 77B>, / ( * \ ,< >, " " ;<;: T 5 " ;<;: T G " < ;; 8-T " < . ;<:? < ;< , :9 6 77 T " < # $ %" " & ( 8 ( 3 ' '2u " "u ) & : =- = " > u ;? ) . = ! < " 6 ;? > u ( "u ; L T 77 ,& " /) C [ u 97W u 5u , 6 u 77 "u , & u =0-) - /) >< " # 1B 5< L T uu :; L u - :? # !1< C? !1 . DD? 01< ) $ %" " & ( /u u < :; L ! u u ( " ( =& 5. #(& < u 11 5 # u < 3 u ;B & ,< 7DB>, "&( / u"u * . u u ,< 77@N 6 ! . u ,< 7C1> u u = ! B ' N , @D 5, / u . u ' u =P 6 3" u u . L T u . u" < u u " >< # . 3" %' ' > u 3" , :@ 7DC>, . 3" , / " ,< : . B = u " 3 ; 1; // - u " #u ;<1: =- < /] < >, u . " < + < 0 M S u G< 2u u = 6 8 >, 8 u ( '2u " u B $ %" " * 1 5 , // - " ( $ $ " "( " $ " $ 6 "$ "( * " " = " "( < " >, u 8 -9 " . " " 7 " u " ( = ;?>, /u " " . " , = 7D1> ;<9 , " "( " u u $ " 6 "$ * < 3 ( u ( $ " = " " u $ %" " , * " " :: 8,-9 " >, 2u' " u :?, / 2u 7 " " , < " " "( $( 7 $ " 8 " $ 6 "$ * $ %" " " " " " <: < " "( " 0 * " " 0 "$ * " " 2u $ 6 " 2u u "$ , * $ %" " * 1 " " < " " ( " " . " u >, S 2u " " . )u = 771>, 9 u >, G < $( 7- 8 u " " u $ " "$ ( 1( < " #u ( * " = " " 9 " u ( = u : ,/ ( u 2u , " "( " $ " $ " " 6 "$ * " & " $ %" " / * 5 " " = . < <; . < <@ , u < ( 8/-9 , = 7DC> " ;<: 7 " " >, /u " " . " ;<: , " "( " " $ " ( " " $ 6 "$ " " 6 " * $ %" " / * . * " :B 7 8/-9 = 7D@> < , u " " = ;<: < <; . <: ( < " >, /u " " . " , " 7 "( 8/- $ " ( " $ 6 "$ * " " $ %" " / * 0$ 9 " u u < ( //, - u " ( $ " 3 = ;<: < " * " $ : $ " , = 7DB>< " 1:? F " 9 " , " = " 5 . " " " 1:?< " , = 7DB> . " . u >, u u 2u < >, 7- : " " . " & ( 0 $ $ %" ( 0 $ $ %" $ " * " ;<: u , / " ( u " " , ( 0 $ $ %" $ " ( " " $ : H5u . @;? F $ " , = 779>, " u ;< : " " = $ " " C; 7 " u Q . " " D? F 9 , = 77;>< < C; . u ;<9 < " >, u :C u 2u , / " " ( u " , ( 0 $ $ %" $ " ( #$ %" 0$ u 7 9 " " ,/ 2u = " " $ : < < , = 771> u " $ 7 : 9 " " u u " " = 1:? F u " S " . u . & F* , " " 1:?< = " >, u u ( < >, ( 0 $ $ %" $ " ( " " " 2u , / " " , /5 /5 ! / & " # $ %" " & ( ! &" 1 ( ( "( $ * & $ %" &" u ( < u " < u :D :; L ! " C u T " 9,1,1 . 9,1,@ =: >, < = 3" = 1@ 5 5 >< . u < u C1 5 " u u ,/ u 2u 3" . u 2u u u < 3" ( 2u " 2u 0G !" "5 & ! =0 G ,< 6 G < X " " && ( ' " . ( u < " %0 " u ,< 77:>, "( $ * & $ %" ! &" " " A @ B 4 ( , N " " " " ( " u " u 1 < = u " & " ) Z % A 97D Z 9; G >, , , "u 2u " N u = C1 5 u # $ %" " / u u 999@1< /5, , u " 5 < 2u u ) > " u , ' u " > u u u " u " =-, , ,< /] < >, / " 4 ( u 9; ' u " " u < " " ' "u < u G :;; = C<: )(, Yu 4 u ' " :7 G <6 G <X " u > 5 . , %u " ' < " " u" u " 4 ( " " 4 " 4 (" < " . " 3 u " 4 < . " 2u " . " . " . , / " " u " 2u u . " u ,/ 5 . 5 u < . " . & ! ' , " /5/ " < # $ %" " B ' 5 = " && ( >, ( "( $ * & $ %" &" & u < " " u = u A@ B 4 ( 9;; 8u 6 # u u @ ' @ & " 3 Z % A @C<; Z :<; G >, " ' ' "u u M " " < , /u # B; &< " u , / u < < B; , < = u = 5 B; , *, 9,1,9> u u " 2u = " u # u . # " " u # u( N" " & 2u " # u > " < !< 8 > # 2u / " 4 ( u @: < " u " " 4 " ' G :;; = )(, Yu u ' u u :<; " ' ' u" " 4 ( " " 4 " 4 (" > u 5 " < G <6 G <X " " . < , %u u " ' " , " < " . " " 4 < . " " . " . " . , / " " u " . " ,/ 5 u 3 . 5 /= < > B ' u < . " . 5 = >, ? / < . 3 < " u ( 4 (< ." " 3 , / < u " 2u u u 5 2u ( u . " 6 , B 0! < / " 2u ;<;: u , 6 P M = u ( - ,< 777>, " B1 " " 5 - 5 %u < # " u u u < ( " " < u u " " . # " " =* " u =0 < " = 4 ( ( u 77B>, & 5 3 771>, / . 5 u . * ' < " ;? u < 77 >, u < " u = " 5 " . * ' < 771< 0 < 77 >, + < 2u " " #u =/ < 7D@N ". / ,< 7DCN + " 2u # ,< 7D9N G " < , 3 u ( u < < =& ( . " < 4 " 77B>, / , # " "' u u " . )u< 771>, . 5 u u 2u " . . 2u 5 u " u , B9 " . u , " < " " u , " < " " " " " < < . , 5, u" u B@: T 191 >< " u @ 9 u u 5, " $ 1 "( ( " " "( u # ! " u " u . , ! &" !( " " && $ " $ < " * 6 % , u =C<C 3" @ 7 " 1 : &< ;: u " * 1&< u ( ;: u ;: ;@ " 4 ( . , " " " , " / " " * 1& . u 6 % =6 u >, u < " " " " , & * 4 ( . u # B@ 2u & 2u u =6 4 ( u >, . u " u * " u 3" &, u ( 6 % " u , 5,, ( 0 $( " 0 ( * "$ " 2# ! $ ( $( " * ( $ $( " 6 % < " " < u < C: u * < : . 1; C: u 2u " , & " 2u u " " : . C@ u . < 11@ u 1; , u u u " 2u 4 ( " ( , 2u u # " < " 3" " u =6 : u u . u" u . 1; = 3" 1; u u u 2u u : " 4 ( u , u < 3"u 2u u" u " u " 4 ( # u 2u #u >< u , u 1>, < " 4 (. 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C; = " 5 . u < u u u " u u C; u 5 5 < ( 5. . < 7DC>< u ,< 7D@N Q . u . . ,< <. " 77;>, u " =+ u 3 " 3 C; . " > , / u = < 2u & F* u " " " < 2u "u ( . " u < u 5 =& u " " . " 5 5 u < u , " " 77B>, " u . 3" u u ( u " < # "u =!5 5 . ,< 77CN 5 . ,< 77BN . ,< 77@>, 3" 9 2u 5u u u . u ( < < . F* , < " = " u 2u > u . 7; F* 2u = " 2u 1 " 2u >, 8 " .T " " 2u " 2u " # " u " " 4 < " u 2u ,< 771N 3" u u " . u 2u u QuM . , 5 u ( 5. =% ,< 77:N !5 . 5 . ,< 77@N ,< 77C>, @ 2u u F* , ;< u 2u u " u < 2u 5 < 5 u =+ 7DC>, u " u 5 < 77@>, < u u " 3 " . P . < " ,< 2u = u . =;< u , u ( # u 2u u u ( 7D@N . " < # > . " " u F* F* u " u u . " , / " u . ;<9 . ;<: < u 77 N . ,< 77:N . u 5 . ;<9 =;<: > =/ < " ( ,< < u 7DB> u . < u u u " ' " u 3" ( 5 , 2u' " %' ' u < B . %' C, & < " u " 7 u u 2u < " < " " u , u 5 u u 5 " " ' ,< 77:N ) 77:N !5 . ,< ,< 77CN 5 . 77CN 5 u " u ,< 77DN S ,< 5 77DN . ,< ,< 777>< . " u , " ' . 2u u 2u' 5 . ,< 77CN &u 5 . u 5 2u ( =* . u u . 3 < 2u u u # " " ( " = " . ,< ,< 779>, 0 5u u " 3 , " " u . 2u " , " " " u u 2u 2u " " 77B>, " 4 ( . 2u u 5G M . ,< ,< 77:>, 2u 77:N 6 " . " 3" 2u ' , . ' 77:N !5 u " ,< . u ". . ' " . : ,< 779N 77:N # " u 2u 77CN ,< =) " u < 5 . u . 3" u(uG < "u =Q . u ( " , " 5 u = . , 77CN P G u u . ,< u# 5 5 u 5 " 77B>, / " " u " " 71 " ' u , 0u u = " P G % / u uM . ,< " u 77D> " " u 2u " 5 u . , " < " " " ( 2u " 2u , u u" %' = . " C, " u u " 2u u " , 79 2u < < ' 77:> 2u u " ,< B . %' , " 2u 2u u u 2u u u u . u u 5 A - A 3 u " . " " " 0 < , / 2u 5 . ,< ,< 77@N 7DDN 77;> 5 . G < , " ,< 7D7N Q ,< 77 N . . u 7CBN 7CB< u " 779N ,< 5 M 7D@N P ,< . . . 77:N 6 * . = ( G M G 77@N 5 < 5 < 7D@>< % ,< 779N . = . 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Gu . ,< " 4 ( u " 779>, u < u . u 4 ( . ,< 7DCN " u , 2u " " . u 5 ( , / , , % u u u " < " = 7D7> . # , . , = 77:> " " u u " u . < # . u . % " . !, u < 5 ( , = 771> . =/ 3" u u # . / Gu G < . )u< 779>, / " u " " < u " u , / " ' 3" " " " = ( . " ,< 7D7>, 0 u . " " < u 2u u " " " ' u 9 " " , " u. , " u u ( " , 0u + u" " < " . " u ;@ u " 4 ( . 9 " , + u u " ) . " " . ,< 7DCN 7D@>, / * 5 ( = . ,< u 779N 5 . < ,< 771N 6 7DDN . * " = < G . )u< 771>, " 3" 7DCN u * . ,< u = ( 779N 0 " ,< . ,< 771N ) . 779N 6 . * u , # , u < u , /u # ( 2u 2u = ( =% & ( . u " ,< u 77@>< u = 1 . C?>, ( . D<:? u @ . 1K < . 4 ( . , ! u #u " u < 2u < 5 " " ( u 2u u 2u u " 3 2u , & # u " u 2u ' " & " 2u 5 " < u u u u 4 ( . 7D@>, < " 5u & F* < < . < " , " G M G Gu . " " < .1 u " ,< u ( :1? u u F 4 (. , u # 3"u u , = 77;> u 3" . P = 77@> 1B<:? , ;: & F* u " ' , 0u u >, u " & < = 5 u u ( 5 . 5 =Q . ,< 779>< " u ,< " 77;>< =Q . 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" ; #$ &" " " . u , % 0 & ( 0 $ $ %" ! " 1;; ! "( &" < :; . :; 2u " u $ u F* < :; < :; F* ;<: u u < ;<: u F* u , / < ;< ;7 =6 @>, , . u" ;<9 " "&( F* ;< " $ !( " ;< / u" " 9>, F* ;<9 F* , . $ "$ "( " < :: u u . =6 " u . :: F* 0 $( : . / ;,5 1 "&( u . 1>, " !( " . u . & F* =6 & ( 0 $ $ %" $ " "&( . F* . F* ;,= 0 $( # $ " ( " 0 "( "( "$ u ! 1 & ( 0 $ $ %" " &" !( " u " ! & "&( D; . 1 ; , / u u A B; u B; u u " F* u 9&< ;< . B; , / u u A C; u 9&< C; u u " F* . C; u " ;< , 4 ( . < . " / u " " 3 < " , 4 ( . u 2u 2u " . 2u , " " < 4 ( . , " u 2u " 0 " 3 =6 :>, 5u u " 3 " . , 2u u < 2u =6 F9& < " u 2u " " " B>, )u . " =6 ; C>, u * 9& . ! 9& . . 6 * 9& % 1CT:; =:@<;?> 1:T:; =:;<;?> ;T:; =1;<;?> 1;T:; =@;<;?> D<:Z 7<: 9:<@Z1;<C 0 / 3" " . 9& " 2u . 2u < =&V;<;:>, 3" T T ' ,/ " u" ' < ! , 6 . . & F* . 6 & F* % 19T@: =: < ?> 17T@: =B@<@?> 9T@: =1D<7?> 19T@: =: < ?> 9<:Z11<; 99<DZ9B<D 0 / 3" " . " 2u . 2u < =&V;<;:>, 1 T ' ,/ 3" T " u" < ' ! / 6 . . . 6 F* % 9BT:: =B:<@?> @DT:: =DC<9?> 9;T:: =:@<:?> @1T:: =CB<@?> 9< Z @< 9:<CZ9@<: 0 / 3" " . " 2u . 2u < =&V;<;:>, 9 T ' ,/ 3" T " u" < ' F* 5 6 ! . . F* ; % ;< @BT:; =71<;?> @1T:; =D@<;?> 9:T:; =C;<;?> 9:T:; =C;<;?> 9CT:; =C@<;?> 9BT:; =C1<;?> 1BT:; =:1<;?> 9;<9Z9;<9 9 <1Z91<@ 3" T ;<: @ T:; =D1<;?> 0 / ;<9 2u " <. =&V;<;:>, @ " 9 <7Z9 <: 3" T < 9;<@Z17<7 " ' ,/ . u" 2u ' ! 6 = " 4 ( . u < . " ! 6 9& 6 =+ - " " F* F ;< 9& F* F ;< 4 (" " 4 T @9TB; =C <C?> 1BTB; =@9<9?> 19TB; =9D<9?> 9:TC; =:;<;?> 1;TC; =1D<B?> 1DTC; =@;<;?> @9TB; =C <C?> 1BT:B =@B<@?> 19T:B =@ < ?> 9:TC; =:;<;?> 1;TB: =9;<D?> 1DTBB =@1<@?> @9TB; =C <C?> 1@TB; =@;<;?> 1 TB; =9:<;?> 1CTC; =9D<B?> :TC; =1 <@?> 1;TC; =1D<B?> @9TB; =C <C?> 1@T:B =@1<7?> 1 T:B =9C<:?> 1CTC; =9D<B?> :TB: =19< ?> 1;TBB =9;<9?> > 6 =+ " " 4 (" " 4 T > 6 " =6 T > 6 " =6 T > / u" ' u : =&V;<;:>, ! A / u ." < ." " 3 " 6 ! / u & = ' 9& F* F ;< 9& F* F / ;< 3" u u =G > & " 3 > - :9<CZ1<1 9<1Z;<B 19A1; - :@<1Z1<: 9< Z;<B 1A 1 - :1<9Z1<: 9<9Z;<B ;A - ::<7Z1<9 :<:Z;<: 1A : - :1<:Z1<: @<7Z;<@ CAD - :9<@Z1<1 :<@Z;<: ;A ; " u =&V;<;:>, B ." < ' ,/ u" ' = A5> ! ; 6 . u " u ! 0 ! @TDD =@<B?> ! / u TDD = < ?> TB1 = C<C?> 3" / " u" C ' BTB1 =7<C?> T u " . u T =&V;<;:>, , ;/ / " " u < u =% " . & " . . ,< 1;;@N ,< . " " " u % " ,< " 77BN / . . ,< " 3" u ( 777N 1 " < # ,< 1;;1N & G . u 4 ( . , ,< 1;;;N % " u " ,< 1;;1N 77B> " " u u u u , u u 3" u" " , ( . . . u u , = 7D7> . % < "' u . , = 77:>< u !, u " " < 2u 2u " " < u " , / " 5 ( " , & =/ 779> . = 3" 1< u u u , u " 5 5 " ' " " 2u " ( . " . u u , / " 2u D . " " 5 5 " " " u < & F* < < u " u 77B>, > & F* u u < Gu " < " < 2u u . 3" =& . / ,< 1;;1>, u" u . C; = . " 5 " u " u " < < u . u =+ < 7DC>, u u u ." 3 = 3" 5. . 9 u . u " u < . " " " .T " " , 2u 5" 2u " . " u # " u ,< 771N < u "u . " 2u u QuM . . ,< 77;>, 2u F* , 2u 5 ,< 7D@N Q . 2u C; =% 5 u ( 5. . ,< 77:N !5 5 . ,< 77@N ,< 77C>, / , / 2u " u u < " , . " " " " u 3" 5" . . ;<9 u , / u F* u F* . F* ;<: =+ < u " 7DC>< u " < " u 3 ( 5 u . u u u u 2u =;< . =;<: > u u =/ . 2u # < u " . , u ,< 77:N , " @ ;< > " , ;< ;<9 u. u 2u u ' < 7D@N < 7DB>, 7 P . ,< 77 N . u u 9& . u F* / " ;< 4 ( . u u 2u < u < . , 2u u u u " u " " " u . 2u 2u " u , # " < " 77:N & ./ =* . ,< 779N u 4 ( . # " , 2u u u < u u = ". # ,< 77:N 6 5G M . " 4 ( . " ,< 779>, " 4 , u u F* u 9&, " 9& u < u ;< " 2u < u . " " " 2u < , # < " < 4 ( " ( # < 2u < u " =* 779N ) . ,< 77:N " . ". ,< 77:N P 5 . . 2u 2u ,< < 77:>, " 2u ,< < 77@>, / " " . u " < u u # " u# 1; u u " , " " u , < . 5 5 2u 5 " 5 u u < 77CN ) 0 . " u u " . ,< 77BN 65 5u " u " . < u = . , . " . ,< 77B>, 3 " " 2u " < 77CN P G " " u . , = 77C>< 2u < 5 ( < , u u 2u F* " " " u ;< " < . " ' . 2u 4 " 2u " u "u u u " ' " " u " u , u # 1 3 ' " u 4 , 2u B u u " u " / " " u " . 2u " 3" 2u A u 5 # , 2u 2u 2u . " , # u " =;< > " " u , , / " 2u " ( u " 5 u 3 2u " < u , u u. " < u u " " , / < < " u u " , / " " u " u , & < u " u 5 " 3 < " . u 2u " , 11 2u u . " , / # " " " . 3 5 " u " o " " A <: , - " " . <: , - " " . u 6 % > u ;< = 1:? . F* F " o ;< = , - " 9 " . @;?< C; D? . > " o u <: 9" = ;< # ( & = , - " 9 " . 9&> u D " > 9& > u $ 1:? u <: " < 6 % > = = u u = o " " " " ;<9 " 1:? . F* F ;< (" ) > $ 19 1:? "( " E C - / u " ' ( *< u G , ( " u . " , 65 ' "u . . 77CN @7A ;97 *< %*< u u < A M ( ;@7, * ,- . " 65 A u u . , . 77DN :;A C:C CBC, ' ( *< * < < ( . ) A , & . , 65 . 1;;1N :DA 7B9 7C1, ' ( *< < ) * , u ' , + ( *< < " , + " < u . " u u 5 1;;BN B9A 1DD 17B, 1@ u . 1;;1N C9A < " %*< %*< u u u A 1 , * < . < , ) +u < ? S< +/< 0 5 . %/< 5 % < +u " ( 65 X< . 77B< @:A C: 5 X< + " X0, + " u 5M . , 5 u . " . 779< 77A @C % . B 5 " @CC, . , X u . 779< 77A B: C;, 5 X< X = .< & & )< >, / M 6 < < 5u u " 5 < = ) &> " u . =) *> u" - 5" u + " D9 & %*, "5 5 u 5< 7D;, " u 5 . , u u 5 M" u u ,X u 5 1 " X0, % . XX, & 5 M . ", & u < %u < 771< ), - " u A D1 , )< u . u < u %*< & " " u u A . , 65 5 " "5 . 77B< @:A C;C C C, *< # &< & < 5 *< " 65 u X< " " . 6 u < 5 . 77;< 9@A 9;9 9 1: , . u u u ( @5 < /. u u . , & " X ,6 X , < 7DD< BC 79, u" 5 u M 5 , /< 0/, u . + " " u %< + ) % G X , 65 , 65 QX, 5 2u . " . u u =!&8> X 5 65 ,- A 6 , . " , + " u < . 7CB< 17A 1: 5 X , < u" u C, < MA Q u M ,6 u " u " G u" . , . 77: < @9A BCC BDC, < 0 . < 5 M 5 )< / u < P . 1B , 17, "5 . 77 < 9:A : 5 " ::, . , 65 " . 2u . X u %< + , ( . . &< * u . < 7D@< 9O :, 0P, - & X< 5 5 &, 1;;1< C A @9 . . 7DB< 1:A @; ,>< - </ < & u u . = / +X< 5 DC, , 65 !< P u * " . " ( 5u 5 . 1;;9< C7A 1;9O1@@, +&, 2u u "5. u * X < X%, - u u . + " "u T @B, . , . Q < , 19, . . 7DD< 17A :: 5 C u u . 771< 9CA 1C 5 . 77 < 17A . " . 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