During the exothermic reaction of CSRT, once the temperature rises, the speed of reaction will accelerate, which leads to releasing more heat, and then the reaction temperature continues to rise. Because the positive feedback, exists in internal process of exothermic reaction the exothermic reaction process is unstable in the condition of open-loop. In the practical polymerization exothermic reaction of CSTR, it is stable and safe to prevent heat accumulation in the reactor and ensure reaction process; the temperature of material inside the reactor is maintained at the setting value through heat exchange between cooling devices and reaction materials. Since the CSRT temperature system of exothermic reaction is open-loop and unstable, there are dangers of runaway reaction, fire and explosion in the system. For the above problem, fault-tolerant control strategy based on the dual control is proposed, and the CSTR with coil and jacket cooling has operation redundant in the temperature control. The effectiveness of strategy is verified by semi-physical simulation experiments.