NATIONAL AUTONOMOUS UNIVERSITY OF MEXICO FACULTY OF VETERINARY MEDICINE 1. COURSE SYLLABUS: LAB ANIMALS PRODUCTION MEDICINE (0671). 2. SEMESTER: Eighth to ten 3. CYCLE: Professional 4. AREA: 5. COURSE TYPE: Animal Health and Medicine, Animal Production and Economics. Theory (elective) 6. DURATION: Hours per week: Total number of hours: 7. REQUIREMENTS: 8 Weeks Theory: 4h Practice:0 h Theory:32 h Practice:0 h All subjects of the intermediate cycle 8. GENERAL OBJECTIVES: The student will learn ethical principles on laboratory animal husbandry and their use in tests, as well as animal testing norms. The student will appreciate the relevance of using animal models in biomedical investigation through their contribution to human health and will acquire knowledge on its development, biological features, reproduction and health status. The student will understand the impact of having several variables affecting testing results by controlling genetics, zoological, nutritional and environmental factors. 9. TEACHING UNITS 9.1 Unit 1 Historical environment, specialty development and current concept of laboratory animals. 9.1.1 Historical perspectives and origins of Laboratory Animal Science. 9.1.2 Worldwide and National present situation of the specialty. 9.1.3 Benefits of animal testing for human and animal health. 9.1.4 Spontaneous and induced concept of animal model and its application in biomedical investigation. 9.1.5 Development and biological characteristics of selected animal models of interest in biomedical investigation. 9.2. Unit 2 Bioethical principles ruling laboratory animal husbandry, care and management and their laws. 9.2.1 Bioethical principles ruling animal testing. 9.2.2 3 R's Principle (replace, reduce, refine). 9.2.3 National laws and regulations, Mexican Official Norm. 9.2.4 Supplementary and alternative methods of laboratory animals. 9.3 Unit 3 Taxonomy, laboratory animal origins and use of rodents most used in investigation. 9.3.1 Relevant anatomic and physiological differences. 9.3.2 Reproductive parameters: Sexual maturity, heat cycle, first service age, gestation, first delivery age, breastfeeding and weaning. 9.3.3 Coupling and housing methods. 9.4 Unit 4 Basic principles of animal housing, environmental needs of laboratory animals and their control. 9.4.1 Animal facility classification. 9.4.2 Construction principles. 9.4.3 Characteristics of equipment and various supplies. 9.4.4 Macro and micro environment. 9.4.5 Influence of environmental factors on animal response to testing. 9.5 Unit 5 Genetic variability, its relevance in testing response and its control. 9.5.1 Nomenclature principles. 9.5.2 Concepts about: Colonies, strains and sub strains. 9.5.3 Non blood colonies, lineages, hybrid strains. 9.5.4 Most used strains of blood colonies. 9.6 Unit 6 Influence of microbiological variable on animal health and wellbeing and its influence in investigation outcomes. 9.6.1 Microbiological variable effect in the quality of investigations and bioethical coherence. 9.6.2 Animal microbiological classification. 9.6.3 Main zoonosis. 9.6.4 Hygiene and disinfection principles. 9.6.5 Biosafety basic principles. 10. BASIC BIBLIOGRAPHY 1. Institute of Laboratory Animal Resources: Guía para el Cuidado y Uso de Laboratory animals. Edición Mexicana. Academia Nacional de Medicina. México, 1999. 2. SAGARPA: Norma Oficial Mexicana para la Producción, Cuidado y Uso de los Laboratory animals. NOM-062-ZOO-1999. 3. Villanueva, S.O. y Hernández, G.R.: Análisis de Costos y su Estimación para Recursos en Bioterios. Instituto Nacional de Ciencias Médicas y Nutrición. Salvador Zubirán. México, D.F. 968-6499-43-1. 2004. 4. Zúñiga, M.J., Tur, J.A. Milocco, S.N., Piñeiro, G.R. Ciencia y Tecnología en Protección y Experimentación Animal. Editorial MC Graw Hill –Interamericana, Madrid, España. 2001. 11. SUPLEMENTARY BIBLIOGRAPHY 1. Baker, G.D.: Natural Pathogens of Laboratory Animals. ASM Press. Washington, 2003. 2. Fox, J.G., Anderson, L.C., Loew, F.M., Quimby, F.W., eds. Laboratory Animal Medicine. 2nd Academic Press, New York, USA, ISBN: 0122639510. 2002. 3. Tena, B. E. Guía de Procedimientos Adecuados Uso y Cuidado de Laboratory animals y Bioterio. Editada por CIPAM (Comisión Interinstitucional de Prácticas Adecuadas de Manufactura de la Industria Farmacéutica), México, DF. 1994. 4. AVMA. Report of the AVMA Panel on Eutanasia. JAVMA 218(5):669-696, 2000. 5. Laboratory Animal Science. A partir del 2000 como: Comparative Medicine. Contemporary Topics in Laboratory Animal Science. Veterinary Pathology. JAVM. TOPIC Investigación Animal. http://www.sciam.com/index.html Cuidado y Uso de Animales. http://www.oiwa.edu/egi-bin/phf.html Animal Care Program & Services UC, Irvine, USA. http://www.rgs.uci.edu/rig/asvetcon.htm Cuidado y Uso de Animales. UK, Kansas City, USA. http://www.ukans.edu/ Cuidado y Uso de Animales. UT, Knoxville, TN, USA. http://www.ra.utk.edu/ora/labanimal/ATTENVET.html Asociación Profesional, USA. http://www.aalas.org Asociación Profesional, Europa. http://www.iclas.org Instituto para el Bienestar Animal, USA. http://www.awic.org Consejo Canadiense de Cuidado Animal, Canadá. http://www. ccac.org.ca Centro Estudios Avanzados IPN, México. http://www. cinvestav.mx Asociación Profesional, UK. http://www. frame.org.uk Oral presentation of the professor with question 12. TEACHING METHODOLOGY sessions. Presentation to the students. Case study. Written exams 13. COURSE EVALUATION Practical reports Task portfolio Class participation Veterinarian with postgraduate studies in the 14. REQUIREMENTS FOR TEACHING THE COURSE area or five years experience.