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ITWHJ[VMHSSLYNLUPTT\UV[OLYHW`HM[LY [^V`LHYZVMZ\ZWLUZPVUPUWH[PLU[Z^P[O asthma Jorge Sánchez,1,2 Ricardo Cardona,1 Andrés Sánchez3 Abstract )(*2.96<5+! 0TT\UV[OLYHW`OHZWYV]LU[VILLMMLJ[P]LPUJVU[YVSSPUNHSSLYNPJHZ[OTH/V^L]LYML^Z[\KPLZOH]LL]HS\H[LK^OL[OLY[OL JVU[YVSHUKYLK\J[PVUVMKY\N[YLH[TLU[WLYZPZ[HM[LY[YLH[TLU[LUKZ www.nietoeditores.com.mx 'ƌƵƉŽ ĚĞ ůĞƌŐŝĂ ůşŶŝĐĂ LJ džƉĞƌŝŵĞŶƚĂů͘ /W^ hŶŝǀĞƌƐŝƚĂƌŝĂ͕ hŶŝǀĞƌƐŝĚĂĚ ĚĞ ŶƟŽƋƵŝĂ͕ DĞĚĞůůşŶ͕ ŶƟŽƋƵŝĂ͕ŽůŽŵďŝĂ͘ 2 &ƵŶĚĂĐŝſŶƉĂƌĂĞůĞƐĂƌƌŽůůŽĚĞůĂƐŝĞŶĐŝĂƐDĠĚŝĐĂƐ LJŝŽůſŐŝĐĂƐ͕ĂƌƚĂŐĞŶĂ͕ŽůŽŵďŝĂ͘ 3 ŽƌƉŽƌĂĐŝſŶhŶŝǀĞƌƐŝƚĂƌŝĂZĂĨĂĞůEƷŹĞnj͘WƌŽŐƌĂŵĂ ĚĞDĞĚŝĐŝŶĂ͕ĂƌƚĂŐĞŶĂ͕ŽůŽŵďŝĂ͘ Recibido: 20 de junio 2015 Aceptado: 22 de octubre 2015 Correspondencia Jorge Sánchez jotamsc@yahoo.com ƐƚĞĂƌơĐƵůŽĚĞďĞĐŝƚĂƌƐĞĐŽŵŽ Sánchez J, Cardona R, Sánchez A. Repercusión de la inmunoterapia con alergenos luego de dos años de suspensión a pacientes con asma. Rev Alerg Méx. 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ĞŶŶŝƐZ͕ĂƌĂďĂůůŽ>͕'ĂƌĐŝĂ͕ĂďĂůůĞƌŽ͕ƌŝƐƟnjĂďĂů'͕ ŽƌĚŽďĂ,͕ĞƚĂů͘ƐƚŚŵĂĂŶĚŽƚŚĞƌĂůůĞƌŐŝĐĐŽŶĚŝƟŽŶƐŝŶ Re vista Sánchez J y col. Impacto de la inmunoterapia con alergenos después de su suspensión Mé xic o 2. Vergara C, Caraballo L. Asthma mortality in Columbia. Ann ůůĞƌŐLJƐƚŚŵĂ/ŵŵƵŶŽů͘ϭϵϵϴ͖ϴϬ;ϭͿ͗ϱϱͲϲϬ͘ 18. ŽŵƉĂůĂƟ͕WĂƐƐĂůĂĐƋƵĂ'͕ŽŶŝŶŝD͕ĂŶŽŶŝĐĂ't͘dŚĞ ĞĸĐĂĐLJŽĨƐƵďůŝŶŐƵĂůŝŵŵƵŶŽƚŚĞƌĂƉLJĨŽƌŚŽƵƐĞĚƵƐƚŵŝƚĞƐ respiratory allergy: results of a GA2LEN meta-analysis. ůůĞƌŐLJ͘ϮϬϬϵ͖ϲϰ;ϭϭͿ͗ϭϱϳϬͲϵ͘ 3. EĞīĞŶ,͕ĂĞŶĂͲĂŐŶĂŶŝ͕DĂůŬĂ^͕^ŽůĞ͕^ĞƉƵůǀĞĚĂ Z͕ĂƌĂďĂůůŽ>͕ĞƚĂů͘ƐƚŚŵĂŵŽƌƚĂůŝƚLJŝŶ>ĂƟŶŵĞƌŝĐĂ͘: /ŶǀĞƐƟŐůůĞƌŐŽůůŝŶ/ŵŵƵŶŽů͘ϭϵϵϳ͖ϳ;ϰͿ͗ϮϰϵͲϱϯ͘ ϭϵ͘ ďƌĂŵƐŽŶ D:͕ WƵLJ ZD͕ tĞŝŶĞƌ :D͘ /ŶũĞĐƟŽŶ ĂůůĞƌŐĞŶ immunotherapy for asthma. Cochrane Database Syst Rev. ϮϬϭϬ;ϴͿ͗ϬϬϭϭϴϲ͘ 4. ĚĞƌt͕ŐĞD:͕ǀŽŶDƵƟƵƐ͘dŚĞĂƐƚŚŵĂĞƉŝĚĞŵŝĐ͘E ŶŐů:DĞĚ͘ϮϬϬϲ͖ϯϱϱ;ϮϭͿ͗ϮϮϮϲͲϯϱ͘ 5. Anandan C, Nurmatov U, van Schayck O, Sheikh A. Is the ƉƌĞǀĂůĞŶĐĞ ŽĨ ĂƐƚŚŵĂ ĚĞĐůŝŶŝŶŐ͍ ^LJƐƚĞŵĂƟĐ ƌĞǀŝĞǁ ŽĨ ĞƉŝĚĞŵŝŽůŽŐŝĐĂůƐƚƵĚŝĞƐ͘ůůĞƌŐLJ͘ϮϬϭϬ͖ϲϱ;ϮͿ͗ϭϱϮͲϲϳ͘ 20. Jacobsen L, Niggemann B, Dreborg S, Ferdousi HA, Halken ^͕ ,ƆƐƚ ͕ Ğƚ Ăů͘ ^ƉĞĐŝĮĐ ŝŵŵƵŶŽƚŚĞƌĂƉLJ ŚĂƐ ůŽŶŐͲƚĞƌŵ ƉƌĞǀĞŶƟǀĞĞīĞĐƚŽĨƐĞĂƐŽŶĂůĂŶĚƉĞƌĞŶŶŝĂůĂƐƚŚŵĂ͗ϭϬͲ LJĞĂƌĨŽůůŽǁͲƵƉŽŶƚŚĞWdƐƚƵĚLJ͘ůůĞƌŐLJ͘ϮϬϬϳ͖ϲϮ;ϴͿ͗ϵϰϯͲϴ͘ ŽůŽŵďŝĂ͗ĂƐƚƵĚLJŝŶϲĐŝƟĞƐ͘ŶŶůůĞƌŐLJƐƚŚŵĂ/ŵŵƵŶŽů͘ ϮϬϬϰ͖ϵϯ;ϲͿ͗ϱϲϴͲϳϰ͘ ϲ͘ Caraballo L, Acevedo N. Allergy in the tropics: the impact ŽĨĐƌŽƐƐͲƌĞĂĐƟǀŝƚLJďĞƚǁĞĞŶŵŝƚĞƐĂŶĚĂƐĐĂƌŝƐ͘&ƌŽŶƚŝŽƐĐŝ ;ůŝƚĞĚͿ͘ϮϬϭϭ͖ϯ͗ϱϭͲϲϰ͘ 7. Burbach G, Heinzerling L, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini S, et al. GA(2)LEN skin test study //͗ĐůŝŶŝĐĂůƌĞůĞǀĂŶĐĞŽĨŝŶŚĂůĂŶƚĂůůĞƌŐĞŶƐĞŶƐŝƟnjĂƟŽŶƐŝŶ ƵƌŽƉĞ͘ůůĞƌŐLJ͘ϮϬϬϵ͖ϲϰ;ϭϬͿ͗ϭϱϬϳͲϭϱ͘ 8. ^ĄŶĐŚĞnj:͕ŝĞnj^͕ĂƌĚŽŶĂZ͘&ƌĞƋƵĞŶĐLJŽĨƐĞŶƐŝƟnjĂƟŽŶƚŽ ĂŶŝŵĂůƐŝŶĂƚƌŽƉŝĐĂůĂƌĞĂ͘ZĞǀůĞƌŐDĞdž͘ϮϬϭϰ͖ϲϭ;ϮͿ͗ϴϭͲϵ͘ ϵ͘ Sanchez J, Diez S, Cardona R. Sensibilización a aeroalergenos en pacientes alérgicos de Medellín, Colombia Revista ůĞƌŐŝĂDĠdžŝĐŽ͘ϮϬϭϮ͖ϱϵ;ϯͿ͗ϭϯϵͲϰϳ͘ 10. &ĂƐĐĞ>͕dŽƐĐĂD͕ĂƌŽĸŽD͕KůĐĞƐĞZ͕ŝƉƌĂŶĚŝ'͘ƚŽƉLJ ŝŶǁŚĞĞnjŝŶŐŝŶĨĂŶƚƐĂůǁĂLJƐƐƚĂƌƚƐǁŝƚŚŵŽŶŽƐĞŶƐŝƟnjĂƟŽŶ͘ ůůĞƌŐLJƐƚŚŵĂWƌŽĐ͘ϮϬϬϳ͖Ϯϴ;ϰͿ͗ϰϰϵͲϱϯ͘ 11. ůnjĂŬĂƌZ,͕ůƐĂŵĂƌĂŝD͘ĸĐĂĐLJŽĨŝŵŵƵŶŽƚŚĞƌĂƉLJĨŽƌ treatment of allergic asthma in children. Allergy Asthma Proc. 2010;31(4):324-30. 12. Cox L. Allergen immunotherapy and asthma: efficacy, ƐĂĨĞƚLJ͕ ĂŶĚ ŽƚŚĞƌ ĐŽŶƐŝĚĞƌĂƟŽŶƐ͘ ůůĞƌŐLJ ƐƚŚŵĂ WƌŽĐ͘ ϮϬϬϴ͖Ϯϵ;ϲͿ͗ϱϴϬͲϵ͘ 13. ĂĚLJ ͕ WŽǁĞůů D͕ ,ĂƌďĞĐŬ Z͕ 'ŝĐůĂƐ W͕ DƵƌƉŚLJ :͕ <ĂƟĂů Z͕ Ğƚ Ăů͘ /Ő' ĂŶƟďŽĚŝĞƐ ƉƌŽĚƵĐĞĚ ĚƵƌŝŶŐ ƐƵďĐƵƚĂŶĞŽƵƐ ĂůůĞƌŐĞŶ ŝŵŵƵŶŽƚŚĞƌĂƉLJ ŵĞĚŝĂƚĞ ŝŶŚŝďŝƟŽŶ ŽĨ ďĂƐŽƉŚŝů ĂĐƟǀĂƟŽŶǀŝĂĂŵĞĐŚĂŶŝƐŵŝŶǀŽůǀŝŶŐďŽƚŚ&ĐŐĂŵŵĂZ// ĂŶĚ&ĐŐĂŵŵĂZ//͘/ŵŵƵŶŽů>ĞƩ͘ϮϬϭϬ͖ϭϯϬ;ϭͲϮͿ͗ϱϳͲϲϱ͘ 14. tŝŶŐ <͕ ^ĂŬĂŐƵĐŚŝ ^͘ ZĞŐƵůĂƚŽƌLJ d ĐĞůůƐ ĂƐ ƉŽƚĞŶƟĂů ŝŵmunotherapy in allergy. Curr Opin Allergy Clin Immunol. ϮϬϬϲ͖ϲ;ϲͿ͗ϰϴϮͲϴ͘ 15. 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Alergia, Asma e Inmunología Pediátricas. ϮϬϭϰ͖Ϯϯ;ϭͿ͗ϲͲϭϰ͘ 23. ŽƵƐƋƵĞƚ:͕>ŽĐŬĞLJZ͕DĂůůŝŶŐ,:͘ůůĞƌŐĞŶŝŵŵƵŶŽƚŚĞƌĂƉLJ͗ ƚŚĞƌĂƉĞƵƟĐǀĂĐĐŝŶĞƐĨŽƌĂůůĞƌŐŝĐĚŝƐĞĂƐĞƐ͘t,KƉŽƐŝƟŽŶ ƉĂƉĞƌ͘:ůůĞƌŐLJůŝŶ/ŵŵƵŶŽů͘ϭϵϵϴ͖ϭϬϮ;ϰWƚϭͿ͗ϱϱϴͲϲϮ͘ 24. Heinzerling LM, Burbach GJ, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini S, et al. GA(2)LEN skin test study /͗';ϮͿ>EŚĂƌŵŽŶŝnjĂƟŽŶŽĨƐŬŝŶƉƌŝĐŬƚĞƐƟŶŐ͗ŶŽǀĞůƐĞŶƐŝƟnjĂƟŽŶƉĂƩĞƌŶƐĨŽƌŝŶŚĂůĂŶƚĂůůĞƌŐĞŶƐŝŶƵƌŽƉĞ͘ůůĞƌŐLJ͘ ϮϬϬϵ͖ϲϰ;ϭϬͿ͗ϭϰϵϴͲϱϬϲ͘ 25. ŝĞůĞŶ^͕<ĂƌĚŽƐW͕DĂĚŽŶŝŶŝ͘^ƚĞƌŽŝĚͲƐƉĂƌŝŶŐĞīĞĐƚƐǁŝƚŚ ĂůůĞƌŐĞŶͲƐƉĞĐŝĮĐŝŵŵƵŶŽƚŚĞƌĂƉLJŝŶĐŚŝůĚƌĞŶǁŝƚŚĂƐƚŚŵĂ͗ a randomized controlled trial. J Allergy Clin Immunol. ϮϬϭϬ͖ϭϮϲ;ϱͿ͗ϵϰϮͲϵ͘ Ϯϲ͘ <ǁŽŶz^͕KŚ^,͕tƵt,͕ĂĞ'͕>ĞĞ,:͕>ĞĞD'͕ĞƚĂů͘ ĐŚĞŵŽŬŝŶĞƐĂƐƉŽƚĞŶƟĂůŝŵŵƵŶŽůŽŐŝĐŵĂƌŬĞƌƐĐŽƌƌĞůĂƚĞĚ ǁŝƚŚĐůŝŶŝĐĂůŝŵƉƌŽǀĞŵĞŶƚŽĨĂƚŽƉŝĐĚĞƌŵĂƟƟƐƉĂƟĞŶƚƐďLJ ŝŵŵƵŶŽƚŚĞƌĂƉLJ͘džƉĞƌŵĂƚŽů͘ϮϬϭϬ͖ϭϵ;ϯͿ͗ϮϰϲͲϱϭ͘ 27. ZŽƐƐŝZ͕DŽŶĂƐƚĞƌŽůŽ'͕/ŶĐŽƌǀĂŝĂ͕DŽŝŶŐĞŽŶW͕&ƌĂƟ&͕ WĂƐƐĂůĂĐƋƵĂ'͕ĞƚĂů͘>ĂĐŬŽĨŶĞŽͲƐĞŶƐŝƟnjĂƟŽŶƚŽWĞŶĂϭ ŝŶƉĂƟĞŶƚƐƚƌĞĂƚĞĚǁŝƚŚŵŝƚĞƐƵďůŝŶŐƵĂůŝŵŵƵŶŽƚŚĞƌĂƉLJ͘ Clin Mol Allergy. 2010;8:4. 28. ĂŶƟůůŽ:&͕WƵĞƌƚĂ>͘EĞǁĂƉƉƌŽĂĐŚĞƐĨŽƌĂůůĞƌŐĞŶͲƐƉĞĐŝĮĐ ŝŵŵƵŶŽƚŚĞƌĂƉLJ͘ŝŽŵĞĚŝĐĂ͘ϮϬϭϬ͖ϯϬ;ϯͿ͗ϰϰϬͲϱϯ͘ Ϯϵ͘ ^ŝŵŽĞŶƐ^͘dŚĞĐŽƐƚͲĞīĞĐƟǀĞŶĞƐƐŽĨŝŵŵƵŶŽƚŚĞƌĂƉLJĨŽƌ ƌĞƐƉŝƌĂƚŽƌLJĂůůĞƌŐLJ͗ĂƌĞǀŝĞǁ͘ůůĞƌŐLJ͘ϮϬϭϮ͖ϲϳ;ϵͿ͗ϭϬϴϳͲϭϬϱ͘ 30. DĞĂĚŽǁƐ͕<ĂĂŵďǁĂ͕EŽǀŝĞůůŝE͕,ƵŝƐƐŽŽŶ͕&ƌLJͲ^ŵŝƚŚ ͕ DĞĂĚƐ ͕ Ğƚ Ăů͘ ƐLJƐƚĞŵĂƟĐ ƌĞǀŝĞǁ ĂŶĚ ĞĐŽŶŽŵŝĐ ĞǀĂůƵĂƟŽŶ ŽĨ ƐƵďĐƵƚĂŶĞŽƵƐ ĂŶĚ ƐƵďůŝŶŐƵĂů ĂůůĞƌŐĞŶ ŝŵŵƵŶŽƚŚĞƌĂƉLJŝŶĂĚƵůƚƐĂŶĚĐŚŝůĚƌĞŶǁŝƚŚƐĞĂƐŽŶĂůĂůůĞƌŐŝĐ ƌŚŝŶŝƟƐ͘,ĞĂůƚŚdĞĐŚŶŽůŽŐLJƐƐĞƐƐŵĞŶƚ͘ϮϬϭϯ͖ϭϳ;ϮϳͿ͘ 31. Bruggenjurgen B, Reinhold T, Brehler R, Laake E, Wiese G, DĂĐŚĂƚĞh͕ĞƚĂů͘ŽƐƚͲĞīĞĐƟǀĞŶĞƐƐŽĨƐƉĞĐŝĮĐƐƵďĐƵƚĂŶĞŽƵƐŝŵŵƵŶŽƚŚĞƌĂƉLJŝŶƉĂƟĞŶƚƐǁŝƚŚĂůůĞƌŐŝĐƌŚŝŶŝƟƐĂŶĚ allergic asthma. Annals of allergy, asthma & immunology: 121 Revista Alergia México ŽĸĐŝĂů ƉƵďůŝĐĂƟŽŶ ŽĨ ƚŚĞ ŵĞƌŝĐĂŶ ŽůůĞŐĞ ŽĨ ůůĞƌŐLJ͕ ƐƚŚŵĂ͕Θ/ŵŵƵŶŽůŽŐLJ͘ϮϬϬϴ͖ϭϬϭ;ϯͿ͗ϯϭϲͲϮϰ͘ 32. Hankin CS, Cox L, Bronstone A, Wang Z. Allergy immunotherapy: reduced health care costs in adults and ĐŚŝůĚƌĞŶ ǁŝƚŚ ĂůůĞƌŐŝĐ ƌŚŝŶŝƚŝƐ͘ : ůůĞƌŐLJ ůŝŶ /ŵŵƵŶŽů͘ ϮϬϭϯ͖ϭϯϭ;ϰͿ͗ϭϬϴϰͲϵϭ͘ 33. ,ĂŶŬŝŶ ^͕ Ždž >͘ ůůĞƌŐLJ ŝŵŵƵŶŽƚŚĞƌĂƉLJ͗ ǁŚĂƚ ŝƐ ƚŚĞ evidence for cost saving? Curr Opin Allergy Clin Immunol. ϮϬϭϰ͖ϭϰ;ϰͿ͗ϯϲϯͲϳϬ͘ 122 2016 abril-junio;63(2) 34. Reinhold T, Ostermann J, Thum-Oltmer S, Bruggenjurgen B. /ŶŇƵĞŶĐĞŽĨƐƵďĐƵƚĂŶĞŽƵƐƐƉĞĐŝĮĐŝŵŵƵŶŽƚŚĞƌĂƉLJŽŶĚƌƵŐ ĐŽƐƚƐŝŶĐŚŝůĚƌĞŶƐƵīĞƌŝŶŐĨƌŽŵĂůůĞƌŐŝĐĂƐƚŚŵĂ͘ůŝŶŝĐĂůĂŶĚ ƚƌĂŶƐůĂƟŽŶĂůĂůůĞƌŐLJ͘ϮϬϭϯ͖ϯ;ϭͿ͗ϯϬ͘ 35. ŚĞŶ:͕yŝĂŶŐ:͕tĂŶŐz͕^ŚŝY͕dĂŶ,͕<ŽŶŐt͘,ĞĂůƚŚ ĞĐŽŶŽŵŝĐƐĂŶĂůLJƐŝƐŽĨƐƉĞĐŝĮĐŝŵŵƵŶŽƚŚĞƌĂƉLJŝŶĂůůĞƌŐŝĐ ƌŚŝŶŝƟƐĂĐĐŽŵƉĂŶŝĞĚǁŝƚŚĂƐƚŚŵĂ͘>ŝŶĐŚƵĂŶŐĞƌďŝLJĂŶ ŚŽƵƚŽƵũŝŶŐǁĂŝŬĞnjĂnjŚŝс:ŽƵƌŶĂůŽĨĐůŝŶŝĐĂůŽƚŽƌŚŝŶŽůĂƌLJŶŐŽůŽŐLJ͕ŚĞĂĚ͕ĂŶĚŶĞĐŬƐƵƌŐĞƌLJ͘ϮϬϭϯ͖Ϯϳ;ϭϳͿ͗ϵϮϱͲϴ͘